Clinical trials
Spasticity clinical trials
Below are recruiting spasticity clinical trials, each written for real people, not researchers. We’re tracking 153 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06494618Recruiting
Botulinum toxin plus shockwave for leg spasticity in cerebral palsy
This study tests if combining botulinum toxin injections with radial extracorporeal shockwave therapy (RESWT) works better than injection alone for reducing leg spasticity in children with cerebral palsy. If your child has spasticity in leg muscles and is already receiving botulinum toxin, they may benefit from this additional therapy.
Istanbul, KadikoyAges 2–18 - NCT07264166Enrolling by invitation
Gene therapy trial for cerebral palsy and HIE
This trial tests a gene therapy given as a nose spray for people with cerebral palsy or HIE. It aims to see if the treatment is safe and helps improve movement over two years.
Monterrey, Nuevo LeónAges 2–65 - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT07253857Recruiting
Hand and arm therapy for children with cerebral palsy
This study tests a special hand and arm therapy for children with spastic cerebral palsy. The therapy also includes leg exercises to improve movement. It may help your child use their hands and arms better.
Lahore, Punjab ProvinceAges 6–12 - NCT07242300RecruitingPhase 3
Testing a new botulinum toxin for arm stiffness after stroke
This trial tests a new injectable medication (Eveotox) to see if it can safely reduce arm or hand stiffness in people who have had a stroke. The goal is to improve daily activities like dressing or cleaning your hand.
Bengbu, AnhuiAges 18–80 - NCT07202195Recruiting
Using stimulation suits at home for MS symptoms
This trial tests whether wearing a special suit at home can help manage muscle stiffness (spasticity) or lack of coordination (ataxia) caused by multiple sclerosis. The suit delivers gentle stimulation to improve movement in your arms or legs.
SteenokkerzeelAges 18 years+ - NCT07190092Recruiting
Brain stimulation for post-stroke muscle stiffness and movement
This study tests a new type of brain stimulation (deep anterior cerebellar stimulation) to see if it can reduce muscle stiffness and improve movement in people who had a stroke 9–36 months ago and still have tightness or weakness that hasn't gotten better with therapy.
BydgoszczAges 18 years+ - NCT06728787Recruiting
Robot-assisted walking for hereditary spastic paraplegia
This trial tests if robot-assisted walking therapy can help people with hereditary spastic paraplegia (a condition causing progressive leg stiffness and weakness) improve their walking ability. It may be an option if you can walk indoors on your own.
Bosisio Parini, Italy/leccoAges 4–70 - NCT07119801Recruiting
Shock wave therapy for arm stiffness after stroke
This trial tests whether shock wave therapy can help reduce muscle tightness in the wrist and hand after a stroke. It may be an option if you have had one stroke, are between 35 and 65 years old, and still have stiffness that bothers you.
DenizliAges 35–65 - NCT05179473Recruiting
Predict and diagnose stiffness after a recent stroke
This study looks at how to predict and measure spasticity (muscle stiffness and tightness) in people after a recent stroke. It may help clinicians better diagnose and understand what to expect as you recover.
Montreal, QuebecAges 18–85 - NCT06281223Recruiting
Brain and spinal cord connection study in spasticity
This study looks at how the brain and spinal cord connect in children with spasticity (muscle stiffness). It will help doctors understand more about this condition by studying patients who are already scheduled for surgery to reduce stiffness.
NiceAges 3–17 - NCT06958289Recruiting
Cold therapy for muscle tightness: long-term effects and brain changes
This study tests if freezing a nerve (cryoneurolysis) can reduce muscle tightness (spasticity) and improve arm movement. It also looks at how the brain may change after treatment. If you have tight muscles that improved with a numbing nerve block, you may be eligible.
London, OntarioAges 18 years+ - NCT06925425Recruiting
Electrical stimulation for arm skills in children with cerebral palsy
This study tests if a special electrical stimulation therapy, used during specific tasks, can improve arm and hand control in children with spastic quadriplegic cerebral palsy. It aims to help kids with moderate to severe motor challenges gain better use of their upper limbs.
Alexandria, EgyptAges 2–6 - NCT05874154Recruiting
Nerve surgery vs botox for spastic foot after stroke
This trial compares two treatments—tibial nerve selective surgery and botulinum toxin (botox) injections—to improve a stiff, turning-in foot after stroke. It aims to use goal-based care to see which option works better for walking and foot function.
BronAges 18–100 - NCT06782490RecruitingPhase 2
Testing a new drug for MS muscle stiffness
This study tests an investigational drug (BMS-986368) to see if it helps reduce muscle stiffness and spasms caused by multiple sclerosis. It may be an option if you have had spasticity for at least 6 months and are not currently using other treatments that cannot be paused.
Birmingham, AlabamaAges 18–70 - NCT06783114RecruitingPhase 2/Phase 3
Testing a new Botox-like injection for arm stiffness after stroke
This study tests an investigational botulinum toxin injection (YY001) to reduce muscle stiffness in the arm after a stroke. It may help you move your arm more easily and improve daily tasks.
Hefei, AnhuiAges 18–75 - NCT06365476Recruiting
Shockwave therapy for arm stiffness after stroke
This trial tests whether shockwave therapy (gentle sound waves) can help relax stiff wrist and finger muscles after a stroke. It is for adults who have had one stroke and have noticeable muscle tightness in their arm.
Taipei, TaipeiAges 18 years+ - NCT06674785Recruiting
Shock wave therapy for shoulder spasticity after stroke
This trial tests if shock wave therapy can reduce shoulder stiffness caused by a stroke. It may help improve shoulder movement and daily comfort.
TaipeiAges 18 years+ - NCT06733025Recruiting
Comparing surgery and Botox for arm spasticity
This trial compares two treatments—Botox injections or surgery—for arm and hand spasticity after a stroke, brain injury, or spinal cord injury. It may help you decide which option works best for you.
MölndalAges 18 years+ - NCT06726434Recruiting
Comparing freezing vs. surgery for foot spasticity after stroke
This trial compares a freezing procedure (cryoneurotomy) with standard surgery to treat foot stiffness after a stroke. It aims to see which method better corrects the foot turning inward and downward, helping you walk more easily.
GarchesAges 18 years+ - NCT06572046Recruiting
Registry for hereditary spastic paraplegia (HSP)
This registry collects information from people with hereditary spastic paraplegia or spastic ataxia to help plan future treatments. It aims to better understand the condition and connect patients with potential therapies.
PisaAges Any age - NCT06001736Recruiting
Nerve transfer surgery for arm weakness after stroke
This study tests a surgery called CC7 transfer, where a nerve from your healthy side is moved to help your weaker arm. It is for people whose arm has stopped getting better after a stroke and still has significant weakness.
Lebanon, New HampshireAges 18–65 - NCT05926596Recruiting
Leg stretching with an on-demand exoskeleton for spasticity
This trial studies whether a wearable exoskeleton that helps with leg stretching can reduce stiffness and improve movement in people with spasticity after a spinal cord injury. It may help you stretch more safely and comfortably, but you must meet specific health and device-wear requirements.
Syracuse, New YorkAges 18 years+ - NCT05518188RecruitingPhase 1/Phase 2
Gene therapy trial for a childhood AP4M1 brain disorder
This trial studies a one-time gene therapy meant to help children with SPG50 disease caused by changes in the AP4M1 gene. Researchers will give the treatment and closely monitor safety and early signs of benefit.
Dallas, TexasAges 4 months–10 years
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Common questions
- Are there clinical trials for spasticity?
- Yes. Clin2 currently lists 153 recruiting spasticity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a spasticity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a spasticity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.