Spine clinical trials

Spine Surgery Recovery: Open vs. Minimally Invasive Approaches

This study compares how people recover their normal walking patterns after surgery for mid-to-lower spine fractures. Researchers will measure your gait (how you walk) and muscle activity to see if the type of surgery affects how quickly you heal.

Study of a two-level disc implant for the neck

This study looks back at patients who already have a Prodisc C Vivo device in two levels of their neck spine. The goal is to learn how well the surgery works over time.

Intrathecal Morphine Versus Intrathecal Dexmedetomidine Compared to Placebo for Postoperative Pain Relief After Spine Fixation Surgeries

Rehabilitation With Empowered STrategies to Optimize REcovery

Irrigation solution for spinal surgery instrumentation

This trial tests a solution used to clean the surgical site during spine surgeries to see if it helps prevent infections. It is for patients having certain types of spine surgery for conditions like deformity, cancer, or trauma.

Steroid injections for back and pelvic pain

This study is testing how well and how safely steroid injections work for different types of back pain. If you join, you'll receive the injection as part of your care and fill out surveys about your pain and ability to do daily activities before and after.

Recovery pillow for spine surgery patients

This study tests a special recovery pillow designed to help you heal more comfortably after lower back fusion surgery. If you join, you will use the pillow after your operation to see if it improves your recovery.

Personalized pain plan for kids getting spine fusion surgery

This trial tests a personalized plan to manage pain around the time of pediatric posterior-lateral spinal fusion surgery. It aims to improve comfort and reduce the chance of pain or opioid problems after surgery by tailoring pain medicines to the child.

Ultra-high-resolution MRI of the spine

This study uses a very powerful 7 Tesla MRI scanner to take detailed pictures of the spine. It compares people with long-term back pain to healthy volunteers to better understand normal spine anatomy.

Tracking long-term results of spine tethering in growing teens

This study follows kids who have a surgery called anterior vertebral body tethering (AVBT) for growing-related, idiopathic scoliosis. It looks at how well the curve stays corrected over time and how the spine grows, which may help improve future care decisions.

Radiation after limited spine surgery for spine metastases

This study tests whether radiation given after limited surgery helps control cancer that has spread to a small area of the spine. It may help reduce tumor growth in the treated spine area and improve local control after operation.

Tranexamic acid during elective back surgery to reduce bleeding

This trial studies whether giving tranexamic acid (a medicine that helps reduce bleeding) during planned lower-back decompression surgery can lower blood loss or related complications. It compares patients who receive the infusion during surgery to those who meet study procedures and safety requirements.

Spine radiosurgery for spinal cord compression

This trial tests a precise radiation technique for people whose spinal tumors are very close to the spinal cord or nerves. It aims to safely give higher radiation doses while limiting damage to the cord.

Ostene in planned open back spine surgery

This trial tests an experimental bone healing material, Ostene, during spine surgery. It may help reduce scar tissue and improve fusion. You are likely eligible if you are having planned open back surgery for nerve decompression and fusion.

3D scanning to guide spine surgery

This trial tests a 3D scanner that maps your spine during surgery to help the surgeon work more accurately. It is for people already planning spine surgery where the back bones are exposed.

Combination pain control after complex spine surgery

This study tests a combination of three medications (methadone, dexmedetomidine, and ketamine) to control pain after major spine surgery. If you are having complex spine surgery, this trial may offer better pain relief without needing as much opioid medication.

Bone cement screws vs. special screws for weak spine bones

This study compares two types of screws used to fix spine fractures or instability in people with brittle bones (osteoporosis). One type uses bone cement to strengthen the screw, and the other uses a special hollow screw. The goal is to see which method works better for reducing pain and stabilizing the spine.

Comparing two therapies for upper back stiffness

This study compares two gentle physical therapy techniques for improving movement in the upper back. It may help if you have stiffness or limited motion between your shoulder blades and are between 18–39 years old.

Synergy Disc cervical disc replacement outcomes study

This trial is for people who are getting or have already received a Synergy Disc implant to replace a damaged disc in the neck. It follows patients over time to see how well the disc performs in relieving nerve pain or spinal cord compression.

Pre-op health boost for elderly spine surgery patients

This trial tests if a 6-week prehabilitation program (exercise and nutrition) before spine surgery helps elderly patients recover better. It is for people 75 or older with long-term lower back problems who need spinal fusion surgery.

Radiofrequency ablation and stabilization for spine tumors

This trial tests a treatment that uses heat to destroy active spine tumors from cancer that has spread, followed by stabilizing the bone. It aims to see if the treatment works by using a special scan (PET-CT) to confirm the results.

Pain medicine after lower back fusion surgery

This study tests whether taking a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen after lumbar spine fusion surgery is safe and helps with pain without affecting bone healing. It may offer an alternative to stronger pain medicines.

Safety follow-up for Ennovate cervical device

This study checks how safely and effectively a cervical device (Ennovate® Cervical) works after it’s been used in routine care. It may help by monitoring real-world safety and performance over time.

Exercise study for neck and low back pain in medical students

This study looks at neck and low back pain in medical students and asks participants to follow a set exercise plan for a period of time. It may help researchers understand what kind of exercise support could improve symptoms in students.