Clinical trials
Systemic Therapy clinical trials
Below are recruiting systemic therapy clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05673148RecruitingPhase 3
Ablation treatment plus usual therapy for limited metastatic bowel cancer
This study tests whether adding “total ablation” (carefully destroying all visible small tumors using surgery, heat/cold treatment, and/or targeted radiation) to standard chemotherapy improves outcomes for people with limited spread of colorectal cancer. It may help by aiming to eliminate all known metastatic spots while you continue usual cancer treatment.
Kingman, ArizonaAges 18 years+ - NCT07698132Recruiting
Psychotherapy for binge eating disorder
This trial tests three levels of psychotherapy (high, medium, and low intensity) to find which works best for binge eating disorder. It aims to help you stop binge episodes and improve your relationship with food.
Ballerup Municipality, Capital RegionAges 18–65 - NCT06884553Recruiting
Robotic arm therapy vs. standard therapy for chronic stroke
This study compares two types of arm therapy for people who had a stroke at least 6 months ago: one using a robotic device and the other using standard occupational therapy (exercises with a therapist). The goal is to see which helps more with arm movement and function.
Florence, ItalyAges 18 years+ - NCT07342426RecruitingPhase 4
Laser therapy for tennis elbow
This trial tests high and low dose laser therapy for people with tennis elbow (lateral epicondylitis) that started less than three months ago. It aims to see if laser treatment can reduce pain and improve healing.
Kaohsiung CityAges 18 years+ - NCT06949111RecruitingPhase 2
Combining radiation and chemo to make colon cancer removable
This trial tests whether giving radiation therapy along with standard chemotherapy before surgery can help shrink advanced colon cancer that has grown through the bowel wall but hasn't spread to other organs. It is for a specific type of colon cancer called pMMR/MSS.
Shijiazhuang, HebeiAges 18 years+ - NCT06660355RecruitingPhase 2
Ruxolitinib vs prednisone for first chronic GVHD treatment
This trial compares two oral medicines, ruxolitinib and prednisone, as the first treatment for chronic graft-versus-host disease (cGVHD) after a stem cell transplant. If you need initial systemic therapy for cGVHD, this study aims to see which drug works better.
Miami, FloridaAges 18 years+ - NCT04045470Recruiting
Skin-device test to find drugs for T-cell lymphoma lesions
This trial tests a tiny device placed directly into skin lymphoma spots to help identify which “candidate” drugs could work. It’s mainly aimed at people with measurable skin involvement from T-cell lymphoma, after they stop certain treatments for a set time.
Boston, MassachusettsAges 18 years+ - NCT06241651Recruiting
Comparing two types of pacemakers for heart failure patients
This trial tests if a new pacemaker method (CSP) works better than the standard method (BiVP) for people with heart failure who already have a right ventricular pacemaker and need an upgrade.
Nanjing, JiangsuAges 18–80 - NCT06058091RecruitingPhase 1/Phase 2
Cell injection therapy for systemic sclerosis
This trial tests a new cell injection treatment (RY_SW01) for people with systemic sclerosis (a condition causing skin thickening and organ issues). It aims to see if the therapy can improve skin hardening and overall symptoms.
Nanjing, JiangsuAges 18–65 - NCT05223803RecruitingPhase 2
Study radiation for early metastatic prostate cancer
This Phase 2 trial tests a radiation-focused approach for people with newly diagnosed (de novo) prostate cancer that has spread to a small number of spots, especially in bone. It aims to see how well the treatment controls the cancer while keeping side effects manageable.
La Jolla, CaliforniaAges 18 years+ - NCT05301881RecruitingPhase 2
Keep the same treatment after limited metastatic growth
This study tests whether continuing your current systemic (whole-body) therapy is safe and helpful when only 1–2 metastatic spots start growing. It also checks whether adding local treatment (such as radiation or ablation) to those spots can better control the cancer.
AlkmaarAges 18 years+ - NCT06349343RecruitingPhase 1
CAR-T cell therapy for hard-to-treat lupus
This trial tests a new type of cell therapy (CAR-T cells) that targets two proteins on immune cells (CD19 and BCMA) to treat lupus that hasn't responded to standard treatments. It may help people with moderate to severe lupus by reducing disease activity without ongoing medication.
WuhanAges 18–70 - NCT06690658Recruiting
Home arm exercises with a robotic trainer
This trial tests whether a robotic trainer can help people do upper body exercises on their own. It may be a good fit if you can sit without back support and follow simple instructions.
Raanana, IsraelAges 18 years+ - NCT07493395RecruitingPhase 2
CAR T-cell therapy for severe systemic sclerosis
This trial tests whether a special type of immune cell therapy, called CAR T-cells, can help people with severe systemic sclerosis (a disease causing skin and organ hardening) that hasn't improved with standard treatments. The goal is to see if it can stop the disease from getting worse.
LilleAges 18–64 - NCT07466238Recruiting
Chemo into the liver plus IV chemo for bile duct cancer
This trial is testing a treatment plan that first delivers chemotherapy directly into the liver (through a thin tube) along with standard IV chemotherapy. The goal is to shrink the tumor enough to allow for surgery or less aggressive treatment later. It is for people with bile duct or gallbladder cancer that has not spread far.
BeijingAges 18–80 - NCT06723041Recruiting
Acupressure to lower anxiety during cancer treatment
This trial tests if acupressure—a gentle pressure technique on specific points—can help reduce anxiety in people receiving cancer therapy. It compares nurse-led acupressure sessions with learning self-administered acupressure.
Rochester, MinnesotaAges 18 years+ - NCT06992375Recruiting
Shoulder manipulation study for volleyball players
This trial tests a shoulder manipulation technique in healthy volleyball players to see if it improves shoulder function and performance. It may help if you play regularly and haven't had recent injuries or surgeries.
GdanskAges 18–30 - NCT05777499Recruiting
Music therapy in specialized neuro-rehabilitation care
This trial studies whether structured music therapy can support people with complex recovery needs after a nervous-system injury while they’re in a specialist rehabilitation unit. If you’re admitted for brain, spinal cord, or nerve injury rehab, it may help improve aspects of recovery through music-based sessions.
LondonAges 16–80 - NCT06350825RecruitingPhase 3
Surgery plus hormone therapy for advanced prostate cancer
This study tests if removing the prostate and giving strong hormone therapy works better than hormone therapy alone for men whose prostate cancer has spread. It aims to improve how long patients live without the cancer worsening.
Nanjing, JiangsuAges 18–75 - NCT06934447RecruitingPhase 1
CAR-T cell therapy for hard-to-treat lupus in kids
This trial tests a new type of cell therapy, called BCMA/CD70 CAR-T, for children with lupus that hasn't improved with standard treatments. The goal is to see if it can safely reduce disease activity.
Hangzhou, ZhejiangAges 5 years+ - NCT07138495Recruiting
Stroke rehab using AI and a smartphone app
This trial tests a smartphone-based therapy (RGS) that uses AI to help people who had a stroke more than 6 months ago improve arm and hand movement. It's for those with mild to moderate arm weakness who can use a phone and sit during therapy sessions.
LimogesAges 18 years+ - NCT07009834Recruiting
Solving challenges with conduction system pacing
This trial is testing a special way to pace the heart's natural electrical system, which may help people who need a pacemaker for certain heart-block conditions or for heart failure treatment. It aims to make pacing work better.
LondonAges 18–100 - NCT02559752Recruiting
Computer brain testing during proton radiation for childhood tumors
This trial studies how children’s thinking and learning skills change while they receive proton beam radiation for a brain/spinal cord tumor. It uses computer-based cognitive tests to better understand brain effects during treatment, which may help future care.
St Louis, MissouriAges 4–21 - NCT07444307RecruitingPhase 1
CAR-T cell therapy for hard-to-treat lupus
This trial tests a new CAR-T cell therapy for people with severe lupus that hasn't improved with standard treatments. The therapy uses specially designed immune cells to target and destroy cells causing the disease.
Hefei, AnhuiAges 18–65
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Common questions
- Are there clinical trials for systemic therapy?
- Yes. Clin2 currently lists 409 recruiting systemic therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a systemic therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a systemic therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.