Thyroid clinical trials

XL092 for advanced thyroid cancer that no longer responds to radioactive iodine

This trial is testing a new oral medication, XL092, for people with advanced thyroid cancer that has stopped responding to radioactive iodine therapy. The goal is to see if XL092 can slow or stop the cancer from growing.

Study of medullary thyroid cancer progression in a registry

This study follows people with medullary thyroid cancer to better understand how the disease changes over time, including in advanced stages. You may help improve future treatment planning and care for people with medullary thyroid cancer.

Study selpercatinib plus I-131 for RET thyroid cancer that cannot take iodine

This trial tests whether combining a targeted pill (selpercatinib) with a radioactive iodine dose (I-131) can shrink thyroid cancer that has spread and no longer responds to radioactive iodine. It is for RET fusion–positive (genetically driven) thyroid cancers where the cancer cannot reliably absorb iodine anymore.

Study of thyroid lumps and thyroid cancer

This study looks at people who have or may have thyroid nodules (lumps in the thyroid gland in your neck) or thyroid cancer, as well as family members who may have inherited a higher risk. It aims to better understand and diagnose these thyroid problems.

Safety and Efficacy of Cryoablation for Thyroid Tumors

Assessing skills for robotic thyroid surgery

This trial is for people having robotic thyroid surgery (removing all or part of the thyroid with a robot). It aims to create a scoring system to measure how well surgeons perform the procedure. You may be eligible if you have a small thyroid cancer or a benign nodule and want the best cosmetic result.

Thyroid nodule embolization pilot trial

This trial tests a minimally invasive procedure that blocks blood flow to large thyroid nodules, which can shrink them and relieve symptoms like trouble swallowing or cosmetic concerns. It's an option for people with benign nodules or Graves disease who want to avoid surgery or other treatments.

Recombinant TSH for radioactive iodine therapy in thyroid cancer

This trial tests whether a medicine called recombinant human thyroid stimulating hormone (rhTSH) can help prepare your body for radioactive iodine (131I) treatment, which aims to destroy any remaining or spreading thyroid cancer cells. It may be a good option if your thyroid cancer has come back or spread and you are able to have radioactive iodine therapy.

Ultrasound study of baby's thyroid in mothers with thyroid issues

This study uses ultrasound to check the baby's thyroid during pregnancy in mothers who have thyroid problems. It aims to see how the thyroid develops and if any extra care is needed.

Thyroid cancer scan with help of a special hormone

This study tests if a man-made hormone (rhTSH) can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has come back or spread. It aims to see if it helps find and treat cancer that doesn't respond well to standard radioactive iodine.

Colchicine treatment for newly diagnosed thyroid inflammation

This trial tests whether colchicine, a medication that reduces inflammation, can help people recently diagnosed with Hashimoto's thyroiditis or subacute thyroiditis (two types of thyroid inflammation). Researchers want to see if it improves symptoms and thyroid function.

Quality of life study around thyroid surgery

This study looks at how thyroid cancer—or thyroid tumors that may be cancer—affect your quality of life before and after surgery. It may help doctors understand what patients experience and how treatment planning could be better.

Liquid blood tests to diagnose thyroid nodules or cancer

This study tests whether a blood “liquid biopsy” can help diagnose thyroid cancer or hard-to-tell thyroid nodules without needing extra procedures. It may help confirm what’s going on before or around planned thyroid surgery.

Testing an iodine-like PET/CT scan for thyroid cancer

This study checks how well a new PET/CT scan (18F-TFB) can find thyroid cancer after a standard iodine whole-body scan. It may help doctors see where the cancer is using an added imaging test, which could improve planning for care.

Using redifferentiation medicines before radioactive iodine for thyroid cancer

This study collects information on how redifferentiation medicines used before radioactive iodine work in everyday care for certain thyroid cancers that are unlikely to respond to radioactive iodine. It may help doctors understand the best real-world way to use these medicines to plan and deliver treatment.

Extension study of linsitinib for thyroid eye disease

This trial tests two doses of an oral medication (linsitinib) for people with active, moderate-to-severe thyroid eye disease who were in a previous study and didn't improve enough or had their bulging come back. It aims to see if continuing treatment can help with eye bulging and other symptoms.

Nerve monitoring during thyroid surgery and voice outcomes

This study tests whether using nerve monitoring during thyroid surgery helps protect the nerves that control your voice. It includes adults having one side of their thyroid removed and tracks voice changes before and after surgery.

Targeted therapy for high-risk BRAF-mutated thyroid cancer

This trial tests two targeted drugs, vemurafenib and cobimetinib, for people with high-risk thyroid cancer that has a specific BRAF V600E mutation. The goal is to see if this combination can help prevent the cancer from coming back after surgery or other initial treatments.

New drug combo for advanced thyroid cancer

This trial tests a new drug called sacituzumab tirumotecan combined with immunotherapy for people with advanced thyroid cancer that cannot be removed by surgery or has spread. It aims to see if this combination can help shrink tumors or slow down the cancer.

Electrical stimulation for pain after thyroid surgery

This trial tests if electrical stimulation can help reduce pain after thyroid surgery. It is for people who have at least moderate pain after their operation.

Low Calcium After Thyroid Surgery Study

This study looks at why some people develop low calcium levels after thyroid surgery. It aims to understand risk factors by reviewing medical records of patients who had their thyroid removed at Minia University Hospital.

Better predicting easy thyroid removal through mouth or under chin

This study compares two approaches for thyroid removal surgery—one through the mouth and one under the chin—to find which is easier to perform. It is for people with thyroid nodules or early thyroid cancer that hasn't spread.

Thyroid issues and heart attack link study

This study looks at whether thyroid problems are connected to heart attacks (acute coronary syndrome). It may help explain why some people have heart issues.

Nerve monitoring methods during thyroid and parathyroid surgery

This study compares two ways to monitor nerves during thyroid or parathyroid surgery to see which method works better. During surgery, doctors use electrical sensors to make sure they don't accidentally damage important nerves in your neck.