Clinical trials
Differentiated Thyroid Cancer clinical trials
Below are recruiting differentiated thyroid cancer clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06007924RecruitingPhase 2
Study of two drugs for advanced thyroid cancer
This trial tests two oral medications, avutometinib and defactinib, for people with advanced thyroid cancer that has specific genetic changes. The goal is to see if these drugs can shrink tumors or slow their growth.
Basking Ridge, New JerseyAges 18 years+ - NCT07874321RecruitingPhase 2
Study of MRG003 for advanced thyroid cancer that has progressed on current therapy
This trial tests an investigational drug called MRG003 added to your current treatment for advanced thyroid cancer that has stopped responding. It may help people with specific types of thyroid cancer and certain tumor markers.
Guangzhou, GuangdongAges 18–80 - NCT06405217Recruiting
Recombinant TSH for radioactive iodine therapy in thyroid cancer
This trial tests whether a medicine called recombinant human thyroid stimulating hormone (rhTSH) can help prepare your body for radioactive iodine (131I) treatment, which aims to destroy any remaining or spreading thyroid cancer cells. It may be a good option if your thyroid cancer has come back or spread and you are able to have radioactive iodine therapy.
Nanjing, JiangsuAges 18–75 - NCT06431620Recruiting
Thyroid cancer scan with help of a special hormone
This study tests if a man-made hormone (rhTSH) can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has come back or spread. It aims to see if it helps find and treat cancer that doesn't respond well to standard radioactive iodine.
Nanjing, JiangsuAges 18–75 - NCT06530316Recruiting
RET inhibitor before surgery for advanced thyroid cancer with RET changes
This trial tests a targeted drug (a RET inhibitor) taken before surgery to help shrink thyroid cancer that has a specific genetic change (RET alteration). It may make surgery easier or more successful.
ShanghaiAges 14–80 - NCT05837260Recruiting
Tracking tumor DNA changes in advanced thyroid cancers
This study looks at a small blood test (called ctDNA) and tumor tissue to understand how advanced thyroid cancers change over time. It may help doctors better monitor cancer growth and guide treatment choices.
LondonAges 18 years+ - NCT07777536RecruitingPhase 2
Radiation for anaplastic and poorly differentiated thyroid cancer
This study is comparing two different ways of giving radiation therapy for anaplastic and poorly differentiated thyroid cancer. The goal is to see which method is more effective in treating the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06149637Recruiting
Lateral neck lymph node surgery for thyroid cancer
This trial tests a surgical procedure to remove cancer-affected lymph nodes on the side of the neck in patients with differentiated thyroid cancer. It aims to improve outcomes for those with confirmed or suspected spread to these nodes.
Medellín, AntioquiaAges 18–99 - NCT06787911RecruitingPhase 2
Donafenib and immunotherapy before surgery for advanced thyroid cancer
This trial tests a combination of two drugs—donafenib (a targeted therapy) and an immunotherapy (anti-PD-1 antibody)—given before surgery for locally advanced differentiated thyroid cancer. The goal is to shrink the tumor to make surgery easier and more complete. If you have this type of thyroid cancer that is hard to remove completely with surgery alone, this study may be an option.
ShanghaiAges 18–80 - NCT07436455Recruiting
New PET scan for thyroid cancer detection
This trial tests a new type of PET scan (F-18 Tetrafluoroborate) to find thyroid cancer cells that don't show up on standard scans. It's for people who have had surgery and radioactive iodine therapy but still have signs of cancer in their blood tests.
Ankara, AnkaraAges 18 years+ - NCT07438847RecruitingPhase 1
New radioactive treatment for advanced thyroid cancer
This trial tests a new radioactive treatment (177Lu-CTR-FAPI) that targets a protein on thyroid cancer cells. It's for people whose thyroid cancer has stopped responding to standard treatments, including radioactive iodine and targeted therapies.
BeijingAges 18 years+ - NCT07419932Recruiting
Pre-surgery treatment for advanced thyroid cancer
This study tests whether giving treatment before surgery (neoadjuvant therapy) helps people with locally advanced thyroid cancer. It aims to shrink the tumor so surgery can be more successful.
Fuzhou, FujianAges 14–80 - NCT07287748RecruitingPhase 1
Studying AF-001 for advanced thyroid cancer
This trial tests a new drug called AF-001 for people with thyroid cancer that has spread and can't be removed with surgery. It's for those who didn't benefit from or can't take standard treatments, or who haven't had radioactive iodine therapy yet.
KashiwaAges 18 years+ - NCT06898437RecruitingEarly Phase 1
Lutetium-177 LNC1004 for advanced thyroid cancer that no longer responds to standard treatments
This trial tests a radioactive drug called 177Lu-LNC1004 for people with a type of thyroid cancer that is no longer responding to standard treatments. The drug targets a protein called FAP found on tumor cells, which may help shrink tumors and slow disease progression.
BeijingAges 18–85 - NCT07092514RecruitingPhase 2
Comparing two doses of lenvatinib for thyroid cancer not helped by iodine
This study compares two doses of lenvatinib (24 mg vs 10 mg per day) to see which works better for people with thyroid cancer that no longer responds to radioactive iodine. It's for those whose cancer is growing or causing symptoms.
St Louis, MissouriAges 18 years+ - NCT07068542Recruiting
New drug combo for advanced thyroid cancer
This trial tests a new drug called sacituzumab tirumotecan combined with immunotherapy for people with advanced thyroid cancer that cannot be removed by surgery or has spread. It aims to see if this combination can help shrink tumors or slow down the cancer.
Hangzhou, ZhejiangAges 18 years+ - NCT06970353RecruitingPhase 2
Study of tunlametinib for NRAS-mutant advanced thyroid cancer
This trial tests a targeted drug (tunlametinib) for advanced thyroid cancer that has a specific genetic change called NRAS mutation. It may help people whose cancer is not responding to standard treatments like radioactive iodine.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06959641RecruitingPhase 2
XL092 for advanced thyroid cancer that no longer responds to radioactive iodine
This trial is testing a new oral medication, XL092, for people with advanced thyroid cancer that has stopped responding to radioactive iodine therapy. The goal is to see if XL092 can slow or stop the cancer from growing.
Torrance, CaliforniaAges 18 years+ - NCT06961084RecruitingPhase 2
I-124 PET/CT scan for diagnosing thyroid cancer
This trial tests whether a new type of scan (I-124 PET/CT) can better detect thyroid cancer compared to standard scans. It may help doctors decide on the best treatment, such as radiation therapy or surgery.
San Francisco, CaliforniaAges 13 years+ - NCT06923826RecruitingPhase 2
Study of sacituzumab govitecan for advanced salivary gland and thyroid cancers
This trial tests a drug called sacituzumab govitecan in people with advanced salivary gland cancer or thyroid cancer that has spread or cannot be removed. The goal is to see if the drug can help shrink or slow down the cancer.
SingaporeAges 21 years+ - NCT06902376RecruitingPhase 1
XL092 and cemiplimab for advanced thyroid cancer without BRAF mutation
This trial tests a combination of two drugs, XL092 and cemiplimab, for people with a rare and aggressive type of thyroid cancer called anaplastic thyroid cancer. The drugs aim to shrink tumors before surgery and help the immune system fight the cancer.
Boston, MassachusettsAges 18 years+ - NCT06860971RecruitingPhase 3
AL2846 capsule vs placebo for advanced thyroid cancer
This study tests a new oral capsule (AL2846) against a placebo in people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if AL2846 can slow or stop cancer growth.
Hefei, AnhuiAges 18–75 - NCT06853925Recruiting
Online program for thyroid cancer symptom management
This study tests a web-based program to help people with thyroid cancer manage symptoms from radioactive iodine (RAI) treatment and improve their quality of life. It is for those who have had RAI within the past three years and are experiencing mild to moderate symptoms.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06730321Recruiting
Assessing skills for robotic thyroid surgery
This trial is for people having robotic thyroid surgery (removing all or part of the thyroid with a robot). It aims to create a scoring system to measure how well surgeons perform the procedure. You may be eligible if you have a small thyroid cancer or a benign nodule and want the best cosmetic result.
ShanghaiAges Any age
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Differentiated Thyroid Cancer trials by city
Studies with a site in or near these metro areas.
Differentiated Thyroid Cancer trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for differentiated thyroid cancer?
- Yes. Clin2 currently lists 64 recruiting differentiated thyroid cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a differentiated thyroid cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a differentiated thyroid cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.