Clinical trials
Thyroid Nodule clinical trials
Below are recruiting thyroid nodule clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04742608Recruiting
Liquid blood tests to diagnose thyroid nodules or cancer
This study tests whether a blood “liquid biopsy” can help diagnose thyroid cancer or hard-to-tell thyroid nodules without needing extra procedures. It may help confirm what’s going on before or around planned thyroid surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT05264857Recruiting
Decision aid for managing suspicious thyroid nodules
This trial studies a decision-support tool to help people make choices about care for thyroid nodules that look indeterminate to cancer on biopsy. It may help you understand options and decide next steps more confidently.
Stony Brook, New YorkAges 18 years+ - NCT06340945Recruiting
Treating benign thyroid nodules with heat
This study uses heat (thermal ablation) guided by ultrasound to shrink benign thyroid nodules that are causing symptoms or cosmetic concerns. It's an option if you can't have surgery or prefer not to.
BeijingAges 18 years+ - NCT06423235RecruitingPhase 4
Prunella oral liquid for thyroid nodules
This trial tests if an herbal liquid made from prunella can shrink benign thyroid nodules. It may be an option for people with solid, non-cancerous nodules who want to avoid surgery.
Chongqing, Chongqing MunicipalityAges 18–65 - NCT06426563Recruiting
Comparing microwave vs radiofrequency for benign thyroid nodules
This study compares two heat-based treatments—microwave ablation (MWA) and radiofrequency ablation (RFA)—for shrinking benign thyroid nodules that are moderate in size. If you have a non-cancerous, solid nodule at least 2 cm wide, this trial may help you avoid surgery.
Hong KongAges 18 years+ - NCT06610604Recruiting
Thyroid nodule treatment and quality of life study
This study looks at how thyroid nodules affect your daily life and feelings after treatment. It compares quality of life in people who had microwave ablation versus those who had thyroid surgery.
Beijing, Beijing MunicipalityAges 18–70 - NCT06729762Recruiting
Ultrasound-guided heat treatment for benign thyroid nodules
This study tests a treatment that uses ultrasound and heat (radiofrequency or microwave) to shrink benign thyroid nodules. It's for people who have a non-cancerous nodule that causes symptoms or worry, and who can't or don't want surgery.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06730321Recruiting
Assessing skills for robotic thyroid surgery
This trial is for people having robotic thyroid surgery (removing all or part of the thyroid with a robot). It aims to create a scoring system to measure how well surgeons perform the procedure. You may be eligible if you have a small thyroid cancer or a benign nodule and want the best cosmetic result.
ShanghaiAges Any age - NCT06733753Recruiting
Ultrasound-guided heat therapy for thyroid nodules
This trial tests a procedure that uses heat to treat thyroid nodules that are not cancerous but have uncertain results from a biopsy. It may be an option for people who cannot or choose not to have surgery.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07046546Recruiting
Thyroid nodule embolization pilot trial
This trial tests a minimally invasive procedure that blocks blood flow to large thyroid nodules, which can shrink them and relieve symptoms like trouble swallowing or cosmetic concerns. It's an option for people with benign nodules or Graves disease who want to avoid surgery or other treatments.
ReadingAges 18 years+ - NCT07226804Recruiting
Pulsed field ablation for benign thyroid nodules
This trial tests a new procedure called nanosecond pulsed field ablation (nsPFA) to shrink benign thyroid nodules that are causing symptoms like tightness in the throat or trouble swallowing.
Houston, TexasAges 18 years+ - NCT07370675Recruiting
Active surveillance for Bethesda IV thyroid nodules
This study is testing whether it is safe to simply monitor (watch closely) a small thyroid nodule that has a certain biopsy result (Bethesda IV) instead of removing it right away. You would not receive a treatment, but would have regular checkups and ultrasounds to see if the nodule changes.
CopenhagenAges 30 years+ - NCT07178080Enrolling by invitation
New 3D imaging for thyroid nodule measurement
This study compares a new 3D technology to standard ultrasound for measuring thyroid nodule volume. It may help doctors better track changes in nodules over time.
Sarasota, FloridaAges 22 years+ - NCT07237373Recruiting
Heat ablation for benign thyroid nodules
This trial tests a minimally invasive procedure called thermal ablation (using heat) to shrink benign thyroid nodules that cause symptoms like pressure or cosmetic issues, or overactive (hot) nodules. It offers an alternative to surgery or radioactive iodine.
BrugesAges 18 years+ - NCT03676647Recruiting
Test DNA methylation from thyroid FNA samples to diagnose cancer
This study looks at a molecular test (DNA methylation pattern) using samples taken during fine-needle aspiration (FNA) of thyroid nodules. It aims to help identify which thyroid nodules that looked “unclear” after the first test may be cancer.
Duarte, CaliforniaAges 19 years+ - NCT06736015Recruiting
Myo-inositol and Selenium for Indeterminate Thyroid Nodules
This trial tests whether taking myo-inositol and selenium supplements can help reduce the risk of thyroid cancer in people with thyroid nodules that are considered 'indeterminate' (TIR3a). The goal is to see if these supplements can prevent the nodules from becoming cancerous.
RomeAges 18 years+ - NCT06225765Recruiting
Scarless thyroid surgery through the mouth vs open surgery
This trial compares a new scarless thyroid surgery (through the mouth) with traditional open thyroid surgery for treating thyroid nodules. It may be an option if you have a benign nodule under 4 cm or a suspicious nodule under 2 cm.
Hong KongAges 18 years+ - NCT03676348Recruiting
Quality of life study around thyroid surgery
This study looks at how thyroid cancer—or thyroid tumors that may be cancer—affect your quality of life before and after surgery. It may help doctors understand what patients experience and how treatment planning could be better.
OsloAges 18 years+ - NCT05189808Recruiting
Radiofrequency treatment for certain thyroid nodules
This trial studies radiofrequency ablation, a procedure that shrinks a thyroid nodule, for thyroid nodules that are unclear on biopsy but have a reassuring “molecular” test. If you have a Bethesda III nodule that tests benign on specific genetic tests, you may be a good candidate to see if this approach helps safely.
New York, New YorkAges 18 years+ - NCT05088187Recruiting
Study of thinking and quality of life after thyroid surgery
This study looks at how thyroid surgery affects thinking (cognition) and day-to-day quality of life. It may help patients and doctors understand what to expect and how to support people after surgery.
StockholmAges 18 years+ - NCT06146764Recruiting
Better ultrasound for thyroid cancer diagnosis
This study uses a special ultrasound method called contrast-enhanced ultrasound (CEUS) to see if it can improve accuracy of diagnosing thyroid cancer. If you have a thyroid nodule and have had certain tests, this trial may help doctors better understand your condition.
Guangzhou, GuangdongAges 18 years+ - NCT06220656Recruiting
Thyroid nodule observation and biopsy study
This study looks at how doctors talk with patients who have a thyroid nodule that may need a biopsy. It aims to improve communication and help patients feel more involved in their care.
Lebanon, New HampshireAges 18 years+ - NCT06929650Recruiting
Radiofrequency ablation for low-risk thyroid cancer
This trial tests a procedure called radiofrequency ablation to treat small, low-risk thyroid cancer. If you have a small nodule (2 cm or less) that is confirmed as cancer or suspicious for cancer (Bethesda 5/6), this treatment may be an option instead of surgery.
Toronto, OntarioAges 18–100 - NCT07428057Recruiting
Low Calcium After Thyroid Surgery Study
This study looks at why some people develop low calcium levels after thyroid surgery. It aims to understand risk factors by reviewing medical records of patients who had their thyroid removed at Minia University Hospital.
Minya, Minya GovernorateAges 18–75
Hear when a new Thyroid Nodule trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Thyroid Nodule trials by city
Studies with a site in or near these metro areas.
Thyroid Nodule trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for thyroid nodule?
- Yes. Clin2 currently lists 45 recruiting thyroid nodule studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a thyroid nodule trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a thyroid nodule trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.