Clinical trials
Total Knee Arthroplasty clinical trials
Below are recruiting total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 227 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04226339Recruiting
Test walking analysis after knee replacement, different alignment methods
This study compares two ways of aligning the knee during a total knee replacement and checks how people walk afterward using a walking test. It may help doctors choose the alignment method that best supports safer, smoother walking.
LyonAges 55–80 - NCT06208267Recruiting
Tranexamic acid for pain and bleeding after hip or knee replacement
This study tests whether a medicine called tranexamic acid (TXA) can reduce pain, improve movement, and lessen bleeding after hip or knee replacement surgery. It is for adults having their first joint replacement at St. Mary's Hospital.
Montreal, QuebecAges 18 years+ - NCT07006545Enrolling by invitation
Getting back to activity after knee replacement
This study looks at how well people can return to daily activities and exercise after total knee replacement surgery. It may help find better ways to guide recovery.
Munich, BavariaAges 18 years+ - NCT06858358Recruiting
Robot vs. standard knee replacement for severe arthritis
This trial compares a robot-assisted knee replacement technique to the standard approach for people with severe knee arthritis. It aims to see which method leads to better recovery and outcomes.
Cluj-Napoca, ClujAges Any age - NCT06447922Enrolling by invitation
Metal Levels After Knee Replacement
This study measures metal levels in the blood after knee replacement surgery. It may help researchers understand how metal from the new joint affects the body.
Rochester, MinnesotaAges 18–100 - NCT07155837Enrolling by invitation
TENS for pain after first knee replacement surgery
This study tests if a TENS device, which uses mild electrical pulses to relieve pain, helps people recover better after their first total knee replacement. It might reduce pain and improve movement.
Adana, AdanaAges 18 years+ - NCT06124482Recruiting
Study of a new knee replacement implant
This trial tests a new knee replacement implant called the FHK®-CK. It is for people who need a new knee due to arthritis or to replace a failed knee implant.
BeaumontAges 18 years+ - NCT06108063RecruitingPhase 1/Phase 2
Losartan to prevent knee stiffness after replacement
This study tests whether losartan, a blood pressure medicine, can prevent excessive scar tissue (arthrofibrosis) after a total knee replacement. Participants receive losartan or a placebo for 6 months after surgery to see if it improves knee motion and reduces stiffness.
Vail, ColoradoAges 18 years+ - NCT03286868Recruiting
Tested knee replacement alignment during knee surgery
This study looks at how a specific computer/measurement approach (“Verasense”) helps position the knee during total knee replacement for people with knee arthritis. It may help improve how the new knee fits and aligns as you recover.
Halifax, Nova ScotiaAges 21–80 - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT07597538Recruiting
How Hip Replacement Changes Knee Position and Function
This study examines whether getting a hip replacement changes how your knee aligns and functions. Researchers will compare knee imaging before and after your surgery to understand this connection.
Asyut, Asyut GovernorateAges Any age - NCT07552415Recruiting
Joint Immobilization After Knee Replacement Revision Surgery
This study tests whether keeping your knee still for a period after revision knee replacement surgery helps improve how well you can bend and straighten it. Researchers want to see if immobilization (using a brace or cast) helps you regain better movement compared to standard care.
New York, New YorkAges 18 years+ - NCT06733597Recruiting
Bone density change after knee replacement with or without cement
This study looks at how bone density in the thigh bone changes after knee replacement surgery, comparing two ways of attaching the new joint (with cement or without). It may help people who have normal bone density or early bone thinning but not full osteoporosis.
Madison, WisconsinAges 55 years+ - NCT06120023Recruiting
Long-term follow-up of the Madison knee replacement system
This study follows patients in France who receive a Madison total knee replacement. It watches how well the knee works and how the patient feels over time, to make sure the implant is safe and effective.
Lyon, RhôneAges 18 years+ - NCT07544264Recruiting
Five-Year Knee Replacement Outcomes Study
This study follows patients who receive a new knee joint replacement for severe knee arthritis or similar conditions. Researchers will track how well the artificial knee works and how patients recover over 5 years to ensure the replacement lasts and improves quality of life.
BolognaAges 50–85 - NCT05288803Recruiting
Personalized rehab plans for veterans after knee replacement
This study tests whether customizing a recovery plan (“trajectory”) can improve rehabilitation for veterans after total knee replacement surgery. You may be eligible if you start outpatient rehab soon after surgery at participating clinics.
Aurora, ColoradoAges 40–90 - NCT07020312RecruitingPhase 2
Brain training to improve muscle recovery after joint surgery
This trial tests whether brain-computer interface training can help you regain muscle control more effectively after knee or hip surgery. It focuses on four common procedures and uses neurofeedback to optimize muscle activation during recovery.
Chicago, IllinoisAges 18 years+ - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT06746168Recruiting
Better pain control after knee replacement surgery
This study tests a new way to manage pain after total knee replacement. It aims to see if a specific local pain block can reduce the need for strong opioids and improve recovery.
Hasselt, LimburgAges 18–85 - NCT07526831Recruiting
Pain Relief Methods for Knee Surgery: Two Nerve Block Approaches
This study compares two ways of numbing nerves around the knee during surgery to see which method reduces pain better after the operation. Both methods use safe, well-established pain-relief techniques.
Kayseri, TalasAges 18 years+ - NCT07021287Recruiting
Cold therapy after knee replacement surgery
This study compares different cold therapy programs to see which works best for pain and swelling after total knee replacement. Everyone in the study receives cold therapy, and the researchers will track recovery outcomes.
Yiwu, ZhejiangAges 18 years+ - NCT07509866Recruiting
Comparing pain relief options for knee replacement surgery
This trial tests two different numbing medicines for knee replacement surgery. It compares a long-acting numbing medicine (liposomal bupivacaine) with a standard one (ropivacaine) mixed with other drugs to see which provides better pain control. The goal is to find a way to reduce pain and improve recovery.
Wuhan, HubeiAges 18–80 - NCT06640491RecruitingPhase 1/Phase 2
Antibiotics via bone injection for knee replacement
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
Houston, TexasAges 18 years+ - NCT07127042RecruitingPhase 2
Testing a drug to reduce bleeding during knee replacement
This trial tests an experimental drug called BT-114143 to see if it reduces bleeding during and after total knee replacement surgery. It may be a good option for people with osteoarthritis who are having their first knee replacement.
Chengdu, Si'ChuanAges 18–70
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Common questions
- Are there clinical trials for total knee arthroplasty?
- Yes. Clin2 currently lists 227 recruiting total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.