Clinical trials
Total Knee Arthroplasty clinical trials
Below are recruiting total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 226 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07629388Recruiting
Nerve block for pain after knee replacement surgery
This trial tests whether adding a nerve block (a numbing injection near the nerve) to the usual pain plan can better control pain after a total knee replacement. The goal is to help you recover with less pain and fewer side effects.
DijonAges 18 years+ - NCT04692714Recruiting
Cemented vs cement-free robotic knee replacement surgery
This trial compares two ways surgeons can attach a knee replacement using robotic-assisted surgery: with cement or without cement. It may help improve how well the new knee lasts and how patients recover after a first-time knee replacement.
LyonAges 50–80 - NCT07598552Recruiting
Brain Function Changes After Same-Day Hip or Knee Surgery
This study checks whether patients who have hip or knee replacement surgery and go home the same day experience any temporary changes in thinking or memory. Researchers want to understand how anesthesia and surgery affect the brain in the short term.
SvendborgAges 70 years+ - NCT07597538Recruiting
How Hip Replacement Changes Knee Position and Function
This study examines whether getting a hip replacement changes how your knee aligns and functions. Researchers will compare knee imaging before and after your surgery to understand this connection.
Asyut, Asyut GovernorateAges Any age - NCT07601906Recruiting
Blood Flow Exercise Therapy After Knee Replacement Surgery
This study tests whether special exercises that temporarily reduce blood flow to your leg can help you recover better after knee replacement surgery. It focuses on reducing pain and improving your ability to bend and straighten your knee.
Lahore, Punjab ProvinceAges 50–65 - NCT07589127Recruiting
Nerve Block for Pain Relief During Knee Replacement
This study tests whether blocking a specific nerve in the knee can reduce pain and improve recovery after total knee replacement surgery. You would receive this nerve block alongside standard anesthesia to see if it helps you need fewer pain medications afterward.
Hjelset, Møre og RomsdalAges 18–80 - NCT07577869Recruiting
Nerve blocks for pain relief after knee replacement
This trial tests two types of numbing injections (nerve blocks) around the knee to help manage pain after total knee replacement surgery. The goal is to see if these injections reduce pain and improve recovery compared to standard pain treatment.
Kayseri, KocasinanAges 18–80 - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07561333Recruiting
Pain Relief Methods for Knee Replacement Surgery
This study compares two different nerve-blocking anesthesia techniques to see which one controls pain better after knee replacement surgery. Both methods are designed to numb the area around your knee so you need less pain medication afterward.
Çorum, CentreAges 18–80 - NCT07551856Recruiting
Robotic vs. manual knee replacement surgery for arthritis
This study compares two ways to perform knee replacement surgery for osteoarthritis: traditional manual surgery versus robotic-assisted surgery. Both are standard approaches; the trial tests whether robotic guidance improves how well your knee works after surgery.
Glasgow, ScotlandAges 18 years+ - NCT07552415Recruiting
Joint Immobilization After Knee Replacement Revision Surgery
This study tests whether keeping your knee still for a period after revision knee replacement surgery helps improve how well you can bend and straighten it. Researchers want to see if immobilization (using a brace or cast) helps you regain better movement compared to standard care.
New York, New YorkAges 18 years+ - NCT07555067Enrolling by invitation
Robotic Knee Replacement Surgery Comparison
This trial compares two different robotic systems used during knee replacement surgery for knee arthritis (wear and tear). The study helps doctors understand which robotic system may provide better results.
Bydgoszcz, Kuyavian-Pomeranian VoivodeshipAges 18 years+ - NCT07545447Recruiting
AI-guided knee surgery education to reduce anxiety and fear
This trial tests whether using an AI-assisted 3D visualization of your knee before surgery can reduce anxiety and fear of movement (kinesiophobia) after knee replacement. You would receive extra visual education along with standard care to see if it helps you feel less stressed and more confident about moving after surgery.
Elâzığ, UlukentAges 55 years+ - NCT07544264Recruiting
Five-Year Knee Replacement Outcomes Study
This study follows patients who receive a new knee joint replacement for severe knee arthritis or similar conditions. Researchers will track how well the artificial knee works and how patients recover over 5 years to ensure the replacement lasts and improves quality of life.
BolognaAges 50–85 - NCT07539467Enrolling by invitation
Nerve Block and Tourniquet for Knee Surgery Pain Relief
This trial tests whether a nerve block (numbing injection near the thigh) combined with a tourniquet (pressure cuff) after knee replacement surgery reduces pain better than standard care. If it works, it could help patients recover more comfortably with less need for strong pain medications.
AnkaraAges 40–85 - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT07526831Recruiting
Pain Relief Methods for Knee Surgery: Two Nerve Block Approaches
This study compares two ways of numbing nerves around the knee during surgery to see which method reduces pain better after the operation. Both methods use safe, well-established pain-relief techniques.
Kayseri, TalasAges 18 years+ - NCT07533188Recruiting
Robotic Knee Replacement Surgery Alignment Techniques Study
This study compares two different ways surgeons can align and position a robotic knee replacement to see which gives better results. You'll be randomly assigned to one approach and tracked over time to measure pain, function, and satisfaction.
SingaporeAges 18 years+ - NCT07522489Recruiting
New knee replacement surgery guidance methods compared
This study compares two ways doctors use computer guidance during robotic knee replacement surgery for severe knee arthritis. The trial tests whether both methods work equally well or if one is better for patient recovery and results.
Warsaw, MazovianAges 18 years+ - NCT07524387Recruiting
Nerve blocks for better leg strength after knee replacement
This study compares two types of numbing injections (nerve blocks) used during knee replacement surgery to see which one helps your thigh muscle recover strength faster. Both are standard care options; the trial tests which works better for early movement after surgery.
Ichinomiya, Aichi-kenAges 20 years+ - NCT07511842Recruiting
Keeping Your Knee Still After Surgery to Reduce Pain
This study tests whether keeping your knee immobilized (held still) for 72 hours after knee replacement surgery helps reduce pain. Researchers will compare this approach to standard care to see if it makes recovery easier.
Sherbrooke, QuebecAges 18 years+ - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07489963Recruiting
Does keeping the posterior cruciate ligament help after knee replacement?
This trial compares two ways of doing robotic-assisted knee replacement: one that keeps the posterior cruciate ligament (a natural knee stabilizer) and one that doesn't. Researchers will see if saving the ligament leads to better knee function a year after surgery.
BordeauxAges 18 years+ - NCT07485803RecruitingPhase 4
Methadone for pain after knee replacement
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
Denver, ColoradoAges 21–75
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Common questions
- Are there clinical trials for total knee arthroplasty?
- Yes. Clin2 currently lists 226 recruiting total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.