Clinical trials
Total Knee Arthroplasty clinical trials
Below are recruiting total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 227 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07130552Recruiting
Comparing two pain relief methods after knee replacement
This study tests two different nerve-block techniques to see which provides better pain control after total knee replacement surgery. The goal is to help you recover more comfortably.
KaramanAges 18–85 - NCT07456787Recruiting
Cold therapy after knee replacement surgery
This trial tests a cold therapy approach (cryopressotherapy) to improve recovery after total knee replacement. It may help reduce pain and swelling so you can move better sooner.
Milan, ItalyAges 18–80 - NCT06971757Recruiting
Is yearly check-up after hip or knee replacement needed?
This study looks at whether routine check-ups one year after hip or knee replacement are helpful or unnecessary. If you've had or are scheduled for a first hip or knee replacement for arthritis, you may be able to join.
AmsterdamAges 50 years+ - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT07356323Recruiting
Study on antibacterial drape for hip or knee replacement
This trial tests if a special antibacterial drape reduces contamination during hip or knee replacement surgery. The drape is placed over the skin to help prevent infection.
Fishers, IndianaAges 22 years+ - NCT05828810Recruiting
Testing antiseptic skin cleaning during hip or knee revision surgery
This study checks whether an antiseptic method for cleaning the skin before surgery is safe and helpful for patients having a repeat (revision) hip or knee replacement. It may help reduce the risk of infection related to surgery.
Barrie, OntarioAges 18 years+ - NCT07336160Recruiting
Nutrition before knee replacement surgery
This trial studies a special nutrition plan before knee replacement surgery to see if it helps recovery. Participants follow enhanced recovery guidelines for eating and drinking before their operation.
Istanbul, IstanbulAges 18 years+ - NCT07324954RecruitingPhase 1
Methylene blue for knee replacement surgery
This study tests if using a blue dye called methylene blue during knee replacement surgery can help doctors see and clean out infections better. It may help people having a first-time knee replacement or those with an infected knee replacement.
Miami, FloridaAges 18 years+ - NCT07053943Enrolling by invitation
Comparing single vs. multiple antibiotic doses for hip and knee replacement
This study compares two ways of giving antibiotics before hip or knee replacement surgery to see which one leads to fewer infections needing another surgery. It may help doctors choose the best antibiotic approach for patients having their first joint replacement.
Amsterdam, North HollandAges Any age - NCT06839807Recruiting
Testing a new device for knee replacement loosening
This study tests a new device (AtMoves Knee System) to help diagnose if a knee replacement is loose. It is for people who have had a knee replacement and have symptoms that might mean the implant is loose, but standard tests have not given a clear answer.
Nijmegen, GelderlandAges 18 years+ - NCT07601906Recruiting
Blood Flow Exercise Therapy After Knee Replacement Surgery
This study tests whether special exercises that temporarily reduce blood flow to your leg can help you recover better after knee replacement surgery. It focuses on reducing pain and improving your ability to bend and straighten your knee.
Lahore, Punjab ProvinceAges 50–65 - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT06565377Recruiting
Pre-surgery program for knee replacement patients
This trial tests a program of exercise, education, and support to help you prepare for knee replacement surgery. It aims to improve your recovery and quality of life.
Geel, AntwerpenAges 18 years+ - NCT07092982Recruiting
Comparing two numbing methods for knee replacement surgery
This study compares two different numbing techniques to see which provides better pain control during and after total knee replacement. It may help find a way to reduce pain and improve recovery.
IstanbulAges 18–75 - NCT07319546Recruiting
Faster recovery after first knee replacement
This study tests a faster, more active recovery program for people having their first total knee replacement. It may help you get back to daily activities sooner after surgery.
Dali, YunnanAges 50–80 - NCT06847113Recruiting
Walking Speed Before and After Knee Replacement
This study follows people who are getting a knee replacement to see how their walking speed changes over time—both when they walk at their own pace and as fast as they can. It helps doctors understand recovery better.
OsloAges 55 years+ - NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT07555067Enrolling by invitation
Robotic Knee Replacement Surgery Comparison
This trial compares two different robotic systems used during knee replacement surgery for knee arthritis (wear and tear). The study helps doctors understand which robotic system may provide better results.
Bydgoszcz, Kuyavian-Pomeranian VoivodeshipAges 18 years+ - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+ - NCT06953375Recruiting
Electrical stimulation for faster recovery after knee replacement
This study tests if adding a gentle electrical stimulation (called NMES) to standard physical therapy helps people recover strength faster after knee replacement surgery. It is for patients who go to specific UCHealth or Intermountain Health therapy clinics after their first total knee replacement.
Aurora, ColoradoAges 18 years+ - NCT06925880Recruiting
Can creatine help seniors recover strength after knee replacement?
This trial tests if taking creatine supplements can help people aged 65+ rebuild muscle mass and strength more quickly after total knee replacement surgery. Participants will take creatine during their standard outpatient rehab program.
Mataró, BarcelonaAges 65 years+ - NCT06627699Recruiting
Study of the Freedom Total Knee System for knee replacement
This study is for people getting a total knee replacement for the first time. It looks at how well the Freedom Total Knee System works in everyday life.
Leawood, KansasAges 18 years+ - NCT06699134Recruiting
Study on Hi-Fatigue G Bone Cement in Knee or Hip Replacement
This study looks at how well a specific bone cement (Hi-Fatigue G) works in people who have had a knee or hip replacement. It aims to help doctors understand if this cement is a good option for holding the artificial joint in place.
Weiden, BavariaAges 18 years+ - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75
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Common questions
- Are there clinical trials for total knee arthroplasty?
- Yes. Clin2 currently lists 227 recruiting total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.