Clinical trials
Total Knee Replacement clinical trials
Below are recruiting total knee replacement clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06182059Recruiting
Pain after knee replacement study
This study looks at long-term pain after total knee replacement surgery. It may help understand why some people have persistent pain and find ways to prevent it.
Monza, Monza BrianzaAges 18–85 - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT07360392Recruiting
Nerve block comparison for knee replacement pain
This study compares two numbing techniques (nerve blocks) for pain relief after knee replacement surgery. The goal is to find which one works better and helps you recover with less pain.
AmasyaAges 18–80 - NCT05823727Recruiting
Collagen supplement study before and after knee replacement
This study tests whether taking collagen peptides can improve how knee tissues heal and remodel after total knee arthroplasty (knee replacement). It also looks at functional recovery and wound healing, especially during the physical therapy period in Little Rock.
Little Rock, ArkansasAges 50–75 - NCT05616884Enrolling by invitation
Cemented vs cementless partial knee replacement study
This study compares two ways of fixing a partial knee replacement: cemented or cementless. It may help doctors learn which method works better for patients with certain types of knee bone.
Alexandria, VirginiaAges 18–85 - NCT05516381Recruiting
Navigation-assisted knee replacement with two alignment methods
This study tests a computer-guided technique for total knee replacement and compares two ways of aligning the new joint. It may help improve how accurately the surgery is done, which could affect comfort and function afterward.
BarcelonaAges 18 years+ - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT05805774Recruiting
Compare fixing versus replacing a fractured thigh bone
This study looks at the best surgical option for an acute (new) fracture of the lower thigh bone near a stable knee replacement. It compares surgery that “fixes” the bone versus surgery that “replaces” part of the bone to help you walk again safely.
Toronto, OntarioAges 65 years+ - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT07775248RecruitingPhase 4
Long-lasting pain relief after knee replacement
This trial tests a new type of pain medicine that is given during knee replacement surgery and slowly releases pain relief over several days. It may help reduce the need for opioid painkillers after surgery.
Grosse Pointe Farms, MichiganAges 18 years+ - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+ - NCT06298721Recruiting
Personalized care to improve knee replacement satisfaction
This study tests a personalized approach to knee replacement surgery designed for people who are at higher risk of being dissatisfied after the procedure. The goal is to see if tailoring care based on patient-reported outcomes can improve satisfaction.
Cleveland, OhioAges 18–80 - NCT07276061Recruiting
Outpatient vs. in-hospital knee replacement recovery study
This study compares recovery after total knee replacement when patients go home the same day versus staying overnight in the hospital. It aims to see if outpatient surgery leads to similar or better recovery.
StrasbourgAges 18 years+ - NCT06321042Recruiting
Knee replacement study using sensor-guided implant placement
This study tests whether using small motion sensors during knee replacement surgery leads to better outcomes. It is for people aged 50–84 with severe knee pain from arthritis or bone damage who are scheduled for a first-time cemented total knee replacement.
Bologna, ItaliaAges 50–85 - NCT02692092Recruiting
Records for your hip or knee replacement care
This registry collects information about people who have a hip or knee replacement at a HealthEast hospital. It helps researchers and the hospital system understand outcomes and improve care.
Saint Paul, MinnesotaAges 18 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT07313449Recruiting
Knee replacement study: 1-year results for a specific prosthesis
This study looks at how well a certain type of cemented total knee replacement works after at least one year. It may help doctors understand long-term outcomes for this specific knee implant.
StrasbourgAges 18 years+ - NCT06963320RecruitingPhase 2
Preventing blood clots after knee replacement with H001
This trial tests whether an experimental capsule (H001) can prevent dangerous blood clots after knee replacement surgery. It is for people who are scheduled for a first-time total knee replacement and are willing to take the study drug instead of standard blood thinners.
Shanghai, Shanghai MunicipalityAges 18–74 - NCT06896240Recruiting
A smoothie supplement before and after knee revision surgery
This study tests whether drinking a special smoothie each day for 2 weeks before and after your knee revision surgery helps reduce inflammation and improve recovery. It is for people who have health conditions that cause inflammation, like diabetes or heart disease, and who are getting a knee replacement.
New York, New YorkAges 40–80 - NCT06309433Recruiting
Bone density after different knee replacement designs
This study looks at how bone density around a new knee replacement changes over time, comparing two different types of knee implants. It may help your surgeon choose the best option for you.
Bologna, ItaliaAges 45 years+ - NCT05459948Recruiting
Follow-up study for a primary knee replacement
This study tracks outcomes after a standard (first-time) total knee replacement using the GMK SpheriKA implant. It mainly looks at how well the knee works in everyday life, including activity and self-checks over time.
MérignacAges 18–80 - NCT06080152Recruiting
Wheeled device use after knee replacement
This study observes how people use wheeled devices (like walkers) after a total knee replacement. It helps doctors understand what patients need during recovery.
Redwood City, CaliforniaAges 18–99 - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT06989229Recruiting
Nutritional care before and after joint replacement surgery
This trial tests if special nutritional support before and after hip or knee replacement helps you recover faster. It is for people having planned (not emergency) surgery.
Brno, CzechiaAges 18 years+
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Common questions
- Are there clinical trials for total knee replacement?
- Yes. Clin2 currently lists 122 recruiting total knee replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.