Clinical trials
Transcatheter Aortic Valve Replacement clinical trials
Below are recruiting transcatheter aortic valve replacement clinical trials, each written for real people, not researchers. We’re tracking 115 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07125469Recruiting
Comparing CT scan measurements to surgery findings for aortic valve replacement
This study checks if measurements taken from a CT scan before surgery match the actual size of the valve measured during surgery. It may help doctors choose the best valve size for people with severe aortic stenosis who need valve replacement.
Cotignola, RavennaAges 18 years+ - NCT07145463Recruiting
New delivery system for severe aortic stenosis treatment
This trial tests a new delivery system (VitaFlow Liberty Flex) for placing a replacement aortic valve in people with severe aortic stenosis. It is designed for patients whose heart anatomy (a steep angle between the heart and aorta) makes the procedure more challenging.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07267117Recruiting
Heart valve disease progression and outcomes study
This study is following people with heart valve disease (leaky or narrowed valves) to understand how the disease changes over time and what problems it may cause. It does not test a new treatment, but helps doctors learn more about valve disease progression.
Fuzhou, FujianAges 18 years+ - NCT07276711Recruiting
Protecting brain during TAVR with EmStop device
This trial tests a new device (EmStop) that helps protect your brain during TAVR (a type of heart valve replacement). The device is placed in arteries to catch any debris that might break loose during the procedure, potentially reducing the risk of stroke.
New Orleans, LouisianaAges 22 years+ - NCT07278310Recruiting
Siegel Valve for Severe Aortic Stenosis (TAVR)
This study tests a new replacement valve called the Siegel, placed through a catheter in your leg (TAVR), for people with severe aortic stenosis. It aims to see if it is safe and effective for patients at low, intermediate, or high surgical risk.
Atlanta, GeorgiaAges 18 years+ - NCT07335900Recruiting
Studying heart healing after TAVI with FAPI-PET scan
This study uses a special type of PET scan (FAPI-PET) to see how the heart heals after a less invasive valve replacement procedure called TAVI. It aims to help doctors better understand the changes in heart tissue after treatment for aortic stenosis.
ShanghaiAges 18 years+ - NCT07366671Recruiting
Testing a new wire for heart valve replacement safety
This trial tests a special wire to monitor heart function during a less invasive valve replacement procedure (TAVI). It aims to improve safety and understanding of the heart's response during the procedure.
Eindhoven, North BrabantAges 50 years+ - NCT07370467Recruiting
MRI study for mitral & tricuspid valve repair
This study uses MRI scans to take detailed pictures of the heart before and after a valve repair procedure. It helps doctors better understand how these new, less invasive treatments affect heart function.
Milan, MilanAges 18 years+ - NCT01737528Recruiting
Transcatheter heart valve therapy registry for adults
This registry collects information from adults who receive a less invasive heart valve procedure (done through a catheter). The goal is to learn how these treatments work in real-world patients and care over time.
Washington D.C., District of ColumbiaAges 18 years+ - NCT02023060Recruiting
Improving function and quality of life after heart valve repair
This study looks at how a less invasive heart valve procedure affects your day-to-day functioning and overall quality of life. If you’re already being considered for a transcatheter (catheter-based) valve replacement, you may be able to join to help understand what improvements patients experience.
JerusalemAges 18–110 - NCT07455292Recruiting
Heart valve study using advanced MRI
This study uses a special type of MRI, called 4D flow MRI, to better understand how severe aortic stenosis (a narrowed heart valve) affects heart function. It may help doctors learn more about different types of this condition and improve future treatment.
San Donato MilaneseAges 18 years+ - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT07516145Recruiting
Robotic catheter repair for leaky tricuspid heart valve
This trial tests a new robotic catheter procedure to repair a leaky tricuspid valve (the valve on the right side of your heart). Instead of open-heart surgery, doctors thread a tiny device through a vein in your neck to fix the valve. It may be an option if you have severe leaking and your heart team thinks surgery is too risky for you.
ShatinAges 18–90 - NCT07556523RecruitingPhase 4
Recovery quality after heart valve replacement with different sedation
This study compares how well patients recover after a minimally invasive heart valve procedure (TAVR) when given different types of sedation. The goal is to find which sedation approach helps patients feel better and recover faster after the procedure.
Glenview, IllinoisAges 18–90 - NCT07648693Recruiting
Brain Protection Device During Aortic Valve Replacement
This trial tests a new device called CHORDS that protects your brain during transcatheter aortic valve replacement (TAVR), a minimally invasive procedure to fix a narrow aortic valve. The device works by blocking debris that might travel to your brain during the procedure.
Bengbu, AnhuiAges 18 years+ - NCT07398911Enrolling by invitation
3D simulated TAVR for aortic valve leak
This trial tests whether a 3D computer simulation can help guide a less invasive procedure (TAVR) to replace a leaky aortic valve. It may be an option for people with severe aortic regurgitation who are at least 65 years old.
Xi’an, ShanxiAges 65 years+ - NCT07045233Enrolling by invitation
Using a brain protection device during TAVR to prevent stroke
This study tests if a special device placed during transcatheter aortic valve replacement (TAVR) can help prevent stroke. It is for adults with severe aortic stenosis who are already scheduled for TAVR.
BeijingAges 18 years+ - NCT06679517Enrolling by invitation
Long-term follow-up for severe aortic stenosis patients considered for TAVI
This study follows patients with severe aortic stenosis (a heart valve condition) who are being evaluated for a keyhole procedure called TAVI. It aims to understand their long-term outcomes after the standard evaluation process.
FerraraAges 18 years+ - NCT06212050Enrolling by invitation
A new valve for severe aortic stenosis in bicuspid valves
This trial tests a special heart valve (ACURATE neo2) in people with severe aortic stenosis who also have a bicuspid aortic valve, a common birth difference. The goal is to see if the valve is safe and works well for these patients.
Bad NauheimAges 18 years+ - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Birmingham, AlabamaAges 18 years+ - NCT05202977Enrolling by invitation
TAVR valve replacement for older adults with aortic valve narrowing
This trial tests a newer transcatheter (catheter-based) aortic valve replacement device to improve symptoms and safety in older adults with severe aortic stenosis. You may qualify if you’re too high-risk for open-heart surgery and the valve/artery measurements fit the device.
Hefei, AnhuiAges 65 years+ - NCT05610566Recruiting
HighLife valve replacement for severe leaking mitral valve
This trial studies a new catheter-based valve replacement system for people with moderate to severe, or severe, mitral valve regurgitation (a leaky mitral valve). It aims to check whether the procedure is safe and can improve heart function compared with expected care.
Suzhou, JiangsuAges 18 years+ - NCT06714500Enrolling by invitation
New valve for severe tricuspid leak in high-risk patients
This trial tests a new device called the Lux-Valve Plus to replace the tricuspid valve without open-heart surgery. It may help people who have severe leaking of the tricuspid valve and are too high-risk for surgery or not eligible for other non-surgical treatments.
Hong Kong, ShatinAges 50–90 - NCT07030062Recruiting
Echo-guided aortic valve replacement (Echo TAVR)
This trial tests a way to replace your aortic valve using only ultrasound (echo) instead of X-rays or dye. It may be a good fit if you have severe aortic stenosis and need to avoid contrast or radiation because of kidney problems or cancer risk.
BeijingAges Any age
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Common questions
- Are there clinical trials for transcatheter aortic valve replacement?
- Yes. Clin2 currently lists 115 recruiting transcatheter aortic valve replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a transcatheter aortic valve replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a transcatheter aortic valve replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.