Clinical trials
Trigeminal Neuralgia clinical trials
Below are recruiting trigeminal neuralgia clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07596485RecruitingPhase 1/Phase 2
RP-008 Plus Varenicline for Trigeminal Neuralgia Pain
This trial tests a new drug called RP-008 combined with varenicline (a quit-smoking medication) to relieve severe facial pain from trigeminal neuralgia. If you've already tried standard pain medications without enough relief, this combination might help reduce your pain attacks.
SherbrookeAges 18–80 - NCT06684275Recruiting
Radiofrequency treatment comparison for trigeminal neuralgia pain
This trial compares two types of radiofrequency treatment (pulsed and thermal) to see which works better for people with trigeminal neuralgia, a condition that causes severe, stabbing facial pain. If you have had facial pain for at least six months that isn't controlled by medicine, this study may help you find relief.
Zagazig, Sharqia ProvinceAges 18–60 - NCT06779578Recruiting
Comparing two types of radiofrequency for trigeminal neuralgia
This study compares two treatments (bipolar vs monopolar pulsed radiofrequency) for people with trigeminal neuralgia that hasn't improved with medication. It aims to see which method provides better pain relief.
AlexandriaAges Any age - NCT06472323Recruiting
Pulsed radiofrequency with platelet-rich plasma for trigeminal neuralgia
This trial tests a treatment that combines pulsed radiofrequency and platelet-rich plasma to see if it works better for trigeminal neuralgia pain that hasn't been helped by standard medicines like carbamazepine.
Beijing, Beijing MunicipalityAges 18–75 - NCT06863324Recruiting
Impact of radiation sensitivity on late side effects of facial pain radiosurgery
This study looks at whether how sensitive people are to radiation affects late side effects after radiosurgery for trigeminal neuralgia. It may help doctors better predict and prevent long-term problems.
Nice, Alpes-maritimesAges 18 years+ - NCT06851910Recruiting
Lacosamide IV for acute trigeminal neuralgia pain
This trial is testing a medication called lacosamide, given through an IV, to treat sudden, severe facial pain attacks in people with trigeminal neuralgia who come to the emergency room. The goal is to see if it helps relieve pain quickly.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT06216886RecruitingPhase 4
Botox injections for trigeminal neuralgia pain
This study tests Botox (onabotulinumtoxinA) injections to reduce pain attacks in people with trigeminal neuralgia who haven't gotten enough relief from medication or don't want surgery. You must have frequent attacks (more than 10 per week) and be on a stable medication dose.
Stanford, CaliforniaAges 18 years+ - NCT05269472Recruiting
Study of nerve signals during facial pain procedures
This study measures nerve activity (electrical signals in nerves) in people who have trigeminal neuralgia and are getting a common facial pain procedure. It may help researchers better understand the condition and improve future treatments.
Minneapolis, MinnesotaAges 18 years+ - NCT05810428Enrolling by invitation
Using AI to predict outcomes and test pain treatment for trigeminal neuralgia
This study uses computer-based (AI) predictions to better understand what happens after a specific procedure for trigeminal neuralgia, a face pain condition. It also checks how well a “pain neuromodulation” approach works and what it feels like over time.
MilanAges 18 years+ - NCT05677243Recruiting
Observational study of radiosurgery for trigeminal neuralgia pain
This study follows people with trigeminal neuralgia to see how radiosurgery treatment affects their facial pain. It may help doctors better understand who benefits when medicines do not control the pain enough.
MonacoAges 18 years+ - NCT05152368RecruitingPhase 1
Tested umbilical cord stem cell exosomes for trigeminal nerve pain
This Phase 1 study tests whether a treatment made from donated umbilical cord stem cell “exosomes” is safe for people with trigeminal neuralgia (severe facial nerve pain). It mainly focuses on safety and tolerability, and it may help by calming nerve-related pain pathways.
St John'sAges Any age - NCT06890897Recruiting
Esketamine with pulsed radiofrequency for shingles-related face pain
This trial tests whether adding esketamine (a medicine related to ketamine) to a standard nerve treatment (pulsed radiofrequency) can better relieve face pain caused by shingles. It may help if you have ongoing, moderate-to-severe pain in your face or scalp.
BeijingAges 18 years+ - NCT05451251RecruitingPhase 1
Deep brain stimulation for severe trigeminal nerve pain
This trial tests whether deep brain stimulation can reduce intense facial pain from trigeminal neuralgia when medicines and prior procedures have not helped. You may be eligible if you’re an adult with a specific MRI finding near the trigeminal nerve pathway.
Sherbrooke, QuebecAges 18 years+ - NCT05051072Recruiting
MRI study in adults with trigeminal neuralgia pain
This study uses a special MRI scan to look at how the trigeminal nerve system is working in people with essential trigeminal neuralgia (face pain) and whether there is nerve involvement. You may be asked to get MRI scans while resting, which can help doctors better understand the cause and guide future treatments.
ParisAges 18 years+ - NCT06261801Recruiting
Acupuncture plus pregabalin for shingles pain on the face
This trial tests whether adding acupuncture (electroacupuncture) to the standard pain medicine pregabalin can better relieve facial shingles pain that started 1 to 3 months ago. It's for people with moderate pain who are willing to try both treatments together.
Hangzhou, ZhejiangAges 18–85 - NCT06290661Recruiting
Nerve stimulation for shingles-related nerve pain
This study tests a treatment called peripheral nerve stimulation (using a small device to send mild electrical pulses) for people with nerve pain after shingles. It's designed for those whose pain is not well managed by usual treatments.
Wuhan, HubeiAges 18 years+ - NCT05738096RecruitingEarly Phase 1
Testing nerve recordings to improve facial pain rhizotomy
This study looks at special nerve testing (nerve recordings) in adults who are scheduled for a procedure called percutaneous rhizotomy for facial pain. The goal is to see whether these recordings can help improve how the procedure works and affects pain.
Minneapolis, MinnesotaAges 18 years+ - NCT02910323Recruiting
Study for cluster headaches and trigeminal nerve pain
This study looks at people with certain severe headache disorders (cluster-type headaches or SUNCT/SUNA) or trigeminal neuralgia (sharp facial nerve pain). Researchers want to better understand these conditions and see how study testing/record review may help care.
Houston, TexasAges 18 years+ - NCT06518421Recruiting
Emotions and Memory in Chronic Facial Nerve Pain
This study looks at how emotions and memory are affected in people with chronic trigeminal neuralgia (a type of facial nerve pain). Participants will have an MRI scan and fill out questionnaires to help researchers understand the link between chronic pain and cognitive changes.
Toronto, OntarioAges 35–60 - NCT01885299Recruiting
Long-term registry for stereotactic radiation treatments
This study collects long-term information from people who receive stereotactic radiosurgery or stereotactic body radiotherapy for tumors or other conditions. It helps researchers understand how these precise radiation treatments work over time.
Colorado Springs, ColoradoAges Any age - NCT06278194Recruiting
Masseter muscle thickness in gasser ganglion radiofrequency treatment
This trial studies how radiofrequency treatment for facial pain affects the thickness of your chewing muscle. It may help improve future treatments.
Istanbul, BaşakşehirAges 40–85 - NCT06949436RecruitingPhase 2
Early Gamma Knife for Trigeminal Neuralgia
This study tests if giving Gamma Knife radiosurgery (a precise beam of radiation) early after diagnosis can help control facial pain from trigeminal neuralgia. It is for people who have not yet tried many medications or are satisfied with their current pain control.
Edmonton, AlbertaAges 18 years+ - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80
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Common questions
- Are there clinical trials for trigeminal neuralgia?
- Yes. Clin2 currently lists 24 recruiting trigeminal neuralgia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a trigeminal neuralgia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a trigeminal neuralgia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.