Clinical trials
Venous Leg Ulcer clinical trials
Below are recruiting venous leg ulcer clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04647240RecruitingPhase 2
Drug trial for stubborn leg ulcers that won’t heal
This Phase 2 trial tests MTX-001 to help heal “venous stasis ulcers,” which are open sores caused by weak leg vein circulation. It may be an option if you’ve tried standard high-compression care for weeks and your ulcer is still not healing.
Tucson, ArizonaAges 18 years+ - NCT07762222Recruiting
Iliac vein stenting for chronic post-thrombotic venous ulcers
This trial tests whether placing a stent (a small mesh tube) in the iliac vein can help heal chronic leg ulcers caused by prior blood clots. The goal is to improve blood flow and reduce symptoms.
CairoAges 18–70 - NCT07230340Enrolling by invitationPhase 4
Placenta tissue for nonhealing leg ulcers
This study tests a special dehydrated human placenta tissue dressing for leg ulcers that won't heal. You will get either standard wound care plus this dressing, or standard care alone; later you may have the chance to receive the dressing.
Rocky Mount, North CarolinaAges 18 years+ - NCT06764953Recruiting
Amnion membrane graft for non-healing leg ulcers
This study tests a special amnion membrane graft to help heal chronic leg ulcers that haven't improved with standard care. The graft is placed on the wound to support healing, and results are compared with standard treatment alone.
Roanoke, VirginiaAges 18 years+ - NCT02047084Enrolling by invitation
Test graft skin vs Apligraf for venous leg ulcers
This trial compares a new type of donated skin graft (human allograft) to Apligraf for treating venous leg ulcers that have not healed with standard care. It aims to see which option heals ulcers better and more safely.
Greenville, South CarolinaAges 21–90 - NCT07510412Recruiting
NuShield plus standard care for venous leg ulcers
This trial tests a new wound covering called NuShield, used with standard care, to help heal leg ulcers caused by poor vein circulation. It may be an option if your ulcer hasn't healed after standard treatment.
Pickerington, OhioAges 18 years+ - NCT03716167Recruiting
Near-infrared laser for healing and pain in leg vein ulcers
This study tests whether a near-infrared laser can improve healing and reduce pain in chronic venous leg ulcers. If you qualify, you may receive laser treatment and will be checked over time for wound healing and pain levels.
Winston-Salem, North CarolinaAges 18 years+ - NCT06453187Enrolling by invitation
Testing wound dressings for diabetic and vein ulcers
This study tests whether special wound dressings (called CAMPs) can help heal diabetic foot ulcers and venous leg ulcers faster. If you have a hard-to-heal sore on your foot or leg, this trial may be an option.
Los Angeles, CaliforniaAges 18–80 - NCT04737941Recruiting
Study of treatment for leg ulcers from weak leg veins
This study looks at people with a healing or healing-worsening leg ulcer caused by weak veins (venous reflux). It may help improve care for this common type of ulcer and reduce time to healing by testing an approach for venous ulcers.
HelsinkiAges 18 years+ - NCT04920253Recruiting
Testing a water-jet treatment to heal certain foot and leg wounds
This trial tests a new “micro water jet” device (Debritom+) to help heal specific hard-to-heal wounds in people who can attend frequent visits. If you qualify, you’ll be assigned to the device treatment or standard care and monitored to see how well the wound heals.
Bradenton, FloridaAges 18 years+ - NCT05303805RecruitingPhase 4
Sevoflurane gel for painful, slow-healing leg ulcers
This trial studies a topical (skin-applied) form of sevoflurane to help painful leg ulcers that are not healing on their own. If you have ongoing ulcer pain and can report it reliably, you may be considered for this treatment study.
PragueAges 18 years+ - NCT05319106Recruiting
Cord blood stem cell treatment for leg venous ulcers
This trial tests human umbilical cord tissue stem cells to help heal venous leg ulcers that have lasted at least one month. It’s for adults who meet specific wound size/depth and health criteria and are willing to follow study visits.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT05588583Recruiting
Tracking drainage from chronic leg or foot ulcers with a dressing
This study follows how much fluid (drainage) a chronic ulcer produces over time using a dressing called Mepilex Up. It may help clinicians better understand how this dressing manages “exuding” ulcers on the leg or foot.
Castro Valley, CaliforniaAges 18 years+ - NCT05608317Recruiting
Track healing of draining leg ulcers with a foam dressing
This study follows how a non-bordered foam dressing helps chronic leg ulcers that leak fluid (exuding). It mainly aims to see how the wound changes over time, and whether the dressing is comfortable and effective along with standard care.
San Francisco, CaliforniaAges 18 years+ - NCT06153589Recruiting
Music therapy for leg ulcer pain relief
This trial tests whether listening to music during wound cleaning can reduce pain for people with leg ulcers caused by vein or artery problems. It aims to make the procedure more comfortable.
Fort-de-FranceAges 18 years+ - NCT06236750Recruiting
Testing a human tissue wound covering for hard-to-heal ulcers
This study is testing a special wound covering made from donated human tissue (amnion/chorion membrane) to see if it helps heal stubborn diabetic foot ulcers or venous leg ulcers that haven't improved with standard care. The covering is placed on the wound to help it heal.
Kobe, HyōgoAges Any age - NCT06350695Recruiting
Compression stockings for heart failure with leg swelling
This trial tests whether wearing compression stockings can help people with heart failure who have leg swelling. Researchers want to see if stockings reduce fluid buildup and improve daily life.
Dallas, TexasAges 18 years+ - NCT06515093Recruiting
New skin grafts for diabetic foot and venous leg ulcers
This study tests two new skin graft products (PelloGraft for diabetic foot ulcers and SanoGraft for venous leg ulcers) to see if they heal wounds faster than standard care. If you have a hard-to-heal foot or leg ulcer, this trial may offer a new option.
Vista, CaliforniaAges 18 years+ - NCT06528873RecruitingPhase 4
COMS light therapy for chronic leg ulcers
This study tests a special light therapy called COMS to help heal chronic leg ulcers. It is for people with venous leg ulcers or mixed ulcers also involving artery disease, and aims to see if the treatment improves wound closure.
GrazAges 18 years+ - NCT06560502Recruiting
Testing new treatments for diabetic foot and leg ulcers
This trial tests whether adding a special treatment (cellular acellular and matrix-like products) to standard wound care helps diabetic foot ulcers and venous leg ulcers heal faster. It may be an option if you have a diabetes-related foot ulcer that hasn't healed with standard care.
Circleville, OhioAges 21 years+ - NCT06693570RecruitingPhase 4
Fish skin graft for hard-to-heal leg ulcers
This trial tests whether applying a special fish skin graft, along with standard compression therapy, helps heal leg ulcers caused by poor vein function (venous leg ulcers) that have not healed with standard care alone. If you have a nonhealing venous leg ulcer, this study may offer a new treatment option.
Monroeville, PennsylvaniaAges 18 years+ - NCT06697925Recruiting
Venous leg ulcer closure durability study
This trial checks how long the closure of a venous leg ulcer lasts after healing. It is only for people who already took part in an earlier study (THOR trial) and had their ulcer fully close within 12 weeks.
Monroeville, PennsylvaniaAges 18 years+ - NCT06707090RecruitingPhase 3
Tissue repair gel for venous leg ulcers
This trial tests a gel that helps heal leg ulcers caused by poor blood flow in the veins. It may help if you have a venous leg ulcer that has not healed on its own after at least 4 weeks.
Tucson, ArizonaAges 18 years+ - NCT06707103RecruitingPhase 3
Gel treatment for venous leg ulcers
This trial tests whether a special gel helps heal venous leg ulcers faster. It is for people with a diagnosed vein problem and a leg ulcer between 2 and 12 square centimeters that has been present for at least 4 weeks.
Jacksonville, FloridaAges 18 years+
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Venous Leg Ulcer trials by city
Studies with a site in or near these metro areas.
Venous Leg Ulcer trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for venous leg ulcer?
- Yes. Clin2 currently lists 50 recruiting venous leg ulcer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a venous leg ulcer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a venous leg ulcer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.