Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,601 recruiting studies in this area right now.
By phase
- Not applicable4,688
- Phase 21,191
- Phase 1563
- Phase 3456
- Phase 1/Phase 2366
- Phase 4227
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer289
- Gastric Cancer281
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University86
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California446
- Arizona184
- Texas142
- Alabama129
- Florida128
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,601 total
- NCT05959616RecruitingPhase 1
Study of controlled Shigella infection in Kenyan adults
This Phase 1 study gives a carefully measured dose of Shigella sonnei to healthy adults to learn about the infection’s safety and how the body responds. It may help researchers build safer future tests or treatments, but it requires a hospital stay and many follow-up visits.
KilifiAges 18–45 - NCT07162506RecruitingPhase 2
Chemo-immunotherapy then surgery or radiation for esophageal cancer
This trial compares two standard treatments for esophageal cancer that has responded to initial chemo-immunotherapy: surgery to remove the tumor or radiation combined with chemotherapy. The goal is to see which approach offers better outcomes and quality of life.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07448142RecruitingPhase 2
Low-dose radiation with immunotherapy and chemo for advanced rectal cancer
This trial tests a combination of low-dose radiation, an immunotherapy drug called pucotenlimab, and chemotherapy for locally advanced rectal cancer that has not spread. The goal is to see if adding radiation helps shrink the tumor more effectively before surgery.
Guangzhou, GuanggongAges 18–75 - NCT07760012Recruiting
Pet scan with new tracer for solid tumors
This study uses a new imaging tracer, called 68Ga-SorB, during a PET/CT scan to look at tumors. It may help doctors see cancer more clearly. The trial is for adults with certain types of solid tumors (such as melanoma, liver, lung, breast, pancreatic, ovarian, or bile duct cancer) who need a PET/CT scan as part of their care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07875530Recruiting
Comparing two anesthesia methods for obese patients having laparoscopic surgery
This trial compares two different anesthesia techniques for obese patients having laparoscopic surgery, to see which one works better and is safer.
Kocaeli, IzmitAges 18–65 - NCT06623396RecruitingPhase 1
Mesothelin-targeted CAR T cells for esophagogastric cancer or mesothelioma
This trial tests a new treatment that uses your own immune cells (T cells) engineered to find and attack cancer cells that have a protein called mesothelin on their surface. It is for people with advanced or recurrent esophagogastric cancer (cancer of the esophagus or stomach) or malignant peritoneal mesothelioma (a rare cancer of the lining of the abdomen). The treatment involves collecting your T cells, modifying them in a lab, and then giving them back to you after a short course of chemotherapy to help them work.
Basking Ridge, New JerseyAges 18 years+ - NCT05972317Recruiting
Personalized diet vs low FODMAP diet for irritable bowel syndrome
This study compares two diet plans for people with irritable bowel syndrome (IBS): a personalized diet tailored to your specific triggers and the low FODMAP diet, which avoids certain carbohydrates that can cause gas and bloating. The goal is to see which approach works better for relieving symptoms.
RehovotAges 18–70 - NCT07458347RecruitingPhase 1
Study of a new drug for advanced solid tumors with a KRAS mutation
This trial tests a new pill, KST-6051, for people with advanced solid tumors (like lung, pancreatic, or colorectal cancer) that have a specific genetic change called a KRAS mutation. The goal is to see if the drug can shrink or control the cancer, and to find the best dose.
Los Angeles, CaliforniaAges 18 years+ - NCT07020221RecruitingPhase 1/Phase 2
Study of VS-7375 for cancers with a KRAS G12D mutation
This study tests an experimental drug called VS-7375 for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to see if the drug can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT07874711Recruiting
Electronic bidets versus water rinsing after anal surgery
This trial compares using an electronic bidet to a regular water rinse (like a handheld bottle) for cleaning after surgery for anal fistula or hemorrhoids. It aims to see if an electronic bidet can improve comfort and healing during recovery.
BrusselsAges 18 years+ - NCT07875582Recruiting
Blood test for better pancreatic cancer diagnosis
This study looks for proteins in the blood that could help doctors tell the difference between pancreatic cancer and non-cancerous pancreatic conditions, such as chronic pancreatitis or benign cysts. By participating, you could help improve early and accurate diagnosis, which may lead to better outcomes for future patients.
IașiAges 18 years+ - NCT07159204RecruitingPhase 2
A trial testing a chemo plus immunotherapy combo for biliary tract cancer
This trial tests a combination of a special form of chemotherapy (paclitaxel micelle) and an immunotherapy for people with advanced biliary tract cancer (cancer of the bile ducts or gallbladder) that has not responded to or stopped working after first treatment. The goal is to see if this combination can help shrink or control the cancer.
Beijing, Beijing MunicipalityAges 18–74 - NCT07875686RecruitingPhase 2
Comparing two muscle-cutting methods for achalasia treatment
This study compares two ways of doing a surgery called POEM to treat achalasia, a condition where the esophagus doesn't empty properly. The surgery cuts the muscle at the lower end of the esophagus to help food pass more easily. The trial will see if cutting the muscle partially works as well as cutting it all the way through.
CairoAges 18–90 - NCT06958536RecruitingPhase 2
Study of brivekimig for moderate-to-severe Crohn's disease
This trial tests a new medicine called brivekimig for people with moderate-to-severe Crohn's disease. It aims to see if the drug can reduce symptoms and inflammation better than standard treatments.
Tucson, ArizonaAges 18–75 - NCT07875218Enrolling by invitation
Hepatitis B care within Zambia's HIV programme
This study looks at how to bring hepatitis B testing and care into the same clinics that already provide HIV services in Zambia. It aims to make it easier for people to get the hepatitis B help they need.
Lusaka, Lusaka ProvinceAges 18 years+ - NCT07805369RecruitingPhase 1
Study of DEM301 for advanced colorectal cancer
This trial tests a new drug called DEM301 for people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if DEM301 can help shrink or control the cancer.
Nedlands, Western AustraliaAges 18 years+ - NCT07697456RecruitingPhase 2
Study of advanced therapies for Crohn's or ulcerative colitis
This study tests advanced treatments for people with moderate to severe Crohn's disease or ulcerative colitis who haven't responded to at least one previous therapy. It aims to find better options for managing these conditions.
Dothan, AlabamaAges 18–75 - NCT07619547Recruiting
Bowel disease immune system study
This study is looking at how the immune system works in people with inflammatory bowel disease (IBD), which includes conditions like Crohn's disease and ulcerative colitis. By comparing blood or tissue samples from people with and without IBD, researchers hope to find better ways to treat the disease in the future.
Bethesda, MarylandAges 18–85 - NCT07071519RecruitingPhase 3
Risankizumab for young people with ulcerative colitis
This study tests risankizumab (a medication that targets inflammation) in young people with ulcerative colitis who haven't improved enough on other treatments. It aims to see if risankizumab can help control symptoms and reduce bowel inflammation.
Phoenix, ArizonaAges 2–17 - NCT04980287Recruiting
Surgery trial for colon cancer spread to stomach-area fat
This trial studies whether a specific surgery that removes the colon’s associated tissue (and part of the nearby stomach-area tissue) improves outcomes for certain colon cancer cases that are at risk of spreading there. If you qualify, your doctors will compare your treatment approach as part of the study to see if it helps.
Wuhan, HubeiAges 18–75 - NCT07424469Recruiting
Leaks in the esophagus or stomach: microbiome role
This study looks at the role of tiny organisms (the microbiome) in leaks from the esophagus or stomach. Researchers will take small tissue samples to learn more about these leaks and how to treat them better.
Dallas, TexasAges 18 years+ - NCT06820463RecruitingPhase 2
Study of telisotuzumab adizutecan plus chemo for metastatic colorectal cancer
This trial tests a new drug combination for people with metastatic colorectal cancer. The study includes an experimental antibody-drug conjugate (telisotuzumab adizutecan) plus standard chemotherapy and targeted therapies, to see if it works better than current options.
Duarte, CaliforniaAges 18 years+ - NCT07595107Recruiting
Using AI to support rectal cancer treatment decisions
This study uses an AI tool to help doctors make treatment decisions for rectal cancer. It looks at MRI reports and other medical information to suggest the best next steps, like surgery, radiation, or chemotherapy.
Jinan, ShandongAges 18 years+ - NCT06239194RecruitingPhase 1/Phase 2
MdX2001 for advanced solid tumors
This trial tests a new drug, MDX2001, for people with advanced solid tumors that have spread. The study aims to find the best dose and see how well it works.
Denver, ColoradoAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,601 recruiting gastroenterology studies from the U.S. registry right now, out of 11,893 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.