Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,871 recruiting studies in this area right now.
By phase
- Not applicable4,905
- Phase 21,176
- Phase 1584
- Phase 3468
- Phase 1/Phase 2390
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer496
- Gastric Cancer297
- Pancreatic Cancer294
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)102
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma87
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University89
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California464
- Arizona175
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,871 total
- NCT00027274Recruiting
Cancer risk in inherited bone marrow failure syndromes
This study looks at why people with inherited bone marrow failure syndromes (rare genetic conditions affecting blood cell production) have higher cancer risk. Researchers want to understand the genetic and medical factors that increase cancer likelihood, which could help doctors monitor and protect affected patients and their families.
Bethesda, MarylandAges 1 day–100 years - NCT02504853Recruiting
Study food allergy patterns and genetics over time
This study follows people with food allergy and some closely related or healthy people to learn how food allergy (and related conditions) develops over time. It may help researchers find causes and better ways to predict and treat food allergy.
Bethesda, MarylandAges 1 day–99 years - NCT07505030Enrolling by invitationPhase 1
Safety study of LYNC-101 in healthy adults
This trial tests a new medicine called LYNC-101 in healthy volunteers to see if it is safe and how the body processes it. If you are a generally healthy adult between 18 and 60, you may be able to help researchers learn about this potential treatment.
Adelaide, South AustraliaAges 3 weeks–2 months - NCT06885788Recruiting
Female Hernia Repair: Preserving vs Removing a Ligament
If you have an inguinal hernia (a bulge in the groin area), this trial compares two ways to do laparoscopic (keyhole) hernia repair: keeping the round ligament of the uterus versus removing it. The study will help doctors learn which way may lead to better outcomes for women like you.
Nanchong, SichuanAges 18 years+ - NCT06875232Enrolling by invitation
Comparing CT and MRI scans for live liver donors
This study looks at how well CT scans and MRI scans (MRCP) show the blood vessels in the liver before a living donor liver donation. It aims to find out which scan is better at planning the surgery.
Rotterdam, South HollandAges 18–60 - NCT07430540Recruiting
A simpler colon cancer screening pathway
This study tests if a more straightforward screening process can work better for people referred with possible colon cancer symptoms. It looks at how a positive stool test (FIT) leads to a diagnosis.
EdinburghAges 18 years+ - NCT07792980Recruiting
Study of gut bacteria in colon cancer surgery
This study uses AI to analyze gut bacteria (microbiome) in people with colon cancer before and after surgery, to see how it relates to the effectiveness of a treatment called MPRO. It may help improve recovery and outcomes.
Seoul, SeoulAges 20–80 - NCT07793227RecruitingPhase 3
Testing a new hepatitis A vaccine in healthy people
This trial tests a new hepatitis A vaccine in healthy people aged 1 year and older. It aims to see how well the vaccine prevents hepatitis A and checks for any side effects.
HanoiAges 1 year+ - NCT07792200Recruiting
Second ultrasound for detecting gallbladder inflammation
This study tests whether doing a second ultrasound a few hours after the first one can help doctors find gallbladder inflammation (cholecystitis) earlier, which could lead to faster treatment.
York, PennsylvaniaAges 18 years+ - NCT07070466RecruitingPhase 2
Ivonescimab with chemotherapy for advanced stomach or esophageal cancer
This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) for people with advanced adenocarcinoma of the esophagus, stomach, or gastroesophageal junction. The drug is designed to help the immune system fight cancer. The study is for people who have not had prior treatment for stage IV disease and whose cancer is HER2 negative.
Santa Monica, CaliforniaAges 18 years+ - NCT07791862Recruiting
Early risk study for relatives of IBD patients
This study looks at healthy family members of people with Crohn's disease or ulcerative colitis to find early signs of these conditions before symptoms appear. It may help doctors predict and prevent inflammatory bowel disease.
Seattle, WashingtonAges birth–55 years - NCT07430527Recruiting
Colorectal cancer pathway review in secondary care
This study reviews care for patients referred urgently with red-flag symptoms that could be colorectal cancer. It aims to understand how the pathway works and improve outcomes.
EdinburghAges 18 years+ - NCT06750094RecruitingPhase 3
Study of amivantamab plus FOLFIRI in colorectal cancer
This trial tests adding amivantamab to standard FOLFIRI chemotherapy for people with certain types of colorectal cancer that have already been treated once. It aims to see if this combination works better than another common treatment (cetuximab or bevacizumab plus FOLFIRI).
Chandler, ArizonaAges 18 years+ - NCT07529457Recruiting
Probiotic treatment for constipation in adults
This study tests whether a probiotic product can help adults with constipation have more regular bowel movements. Probiotics are beneficial bacteria that may improve digestive health.
Suzhou, JiangsuAges 18–65 - NCT07428629Recruiting
Insomnia treatment trial for people with ulcerative colitis
This trial tests whether a sleep-focused therapy can help people with active ulcerative colitis who also have trouble sleeping. It aims to improve both sleep and UC symptoms.
Lebanon, New HampshireAges 18 years+ - NCT06997497RecruitingPhase 3
Study of Calderasib with other drugs for colorectal cancer
This trial tests a new drug called Calderasib combined with targeted therapy or chemotherapy for people with advanced colorectal cancer that has a specific genetic change (KRAS G12C mutation). It may be an option for those who have not had prior treatment for advanced disease.
Los Angeles, CaliforniaAges 18 years+ - NCT07328516Enrolling by invitation
Farm childhood health study for adult children
This study looks at how early-life exposures on farms might influence long-term health. If you are an adult child of a farmer or farmworker from the Agricultural Health Study, and you spent time on a farm as a child, you may be able to join.
Bethesda, MarylandAges 18–99 - NCT07577843RecruitingPhase 3
Testing JNJ-78934804 for moderate to severe Crohn's disease
This study tests a new drug called JNJ-78934804 for people with moderate to severe Crohn's disease who have not responded well to or can't tolerate current treatments. The goal is to see if this drug can reduce inflammation and symptoms in the digestive tract.
Anaheim, CaliforniaAges 18 years+ - NCT07293689Recruiting
Precision Medicine in Achalasia (PREMEDIA) Study
This study at Northwestern University is looking for people with certain severe esophageal motility disorders (like achalasia) to see if a personalized medicine approach can improve treatment. It focuses on those who haven't had prior surgery or recent endoscopic treatments.
Scottsdale, ArizonaAges 18 years+ - NCT07606339Recruiting
Guselkumab for moderate-to-severe Crohn's or ulcerative colitis
This study tests guselkumab, a medication that reduces inflammation in the gut, for people with moderate-to-severe Crohn's disease or ulcerative colitis who haven't previously tried certain similar biologic drugs. The goal is to see how well it works and is tolerated in real-world use.
ViennaAges 18 years+ - NCT07790718Recruiting
Exercise program to prevent colorectal cancer after prostate radiation
This study tests whether an exercise program can help prevent colorectal cancer in men who have had pelvic radiation for prostate cancer. It involves using an iPhone app to track activity and attending exercise sessions.
Duarte, CaliforniaAges 40–80 - NCT06666985RecruitingPhase 4
Spinal morphine for pain relief after major abdominal surgery
This trial tests whether a single injection of morphine into the fluid around the spine can provide better pain relief after planned laparoscopic or robotic abdominal surgery. If you are having one of several types of major abdominal surgery that lasts at least 2 hours and requires a hospital stay of at least 1 day, this study may be an option.
Guangzhou, GuangdongAges 18 years+ - NCT07196748RecruitingPhase 3
Icotrokinra for adults and teens with moderate to severe ulcerative colitis
This trial tests a new oral medication, icotrokinra, for people with moderately to severely active ulcerative colitis. It may be an option if you have not responded well enough to standard treatments or newer advanced therapies.
Chandler, ArizonaAges 12 years+ - NCT07520747Recruiting
Korean Children's IBD Disease and Treatment Database Study
This study looks at health records of children in Korea who have inflammatory bowel disease (Crohn's disease or ulcerative colitis) to understand their medical care, treatments, and healthcare use. Researchers are not testing a new drug—they're analyzing existing medical information to learn more about how these diseases are managed in children.
SuwonAges Up to 17 years
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,871 recruiting gastroenterology studies from the U.S. registry right now, out of 12,272 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.