Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,230 recruiting studies in this area right now.
By phase
- Not applicable3,146
- Phase 21,063
- Phase 1820
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma183
- Rheumatoid Arthritis140
- Type 1 Diabetes134
- Atopic Dermatitis130
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections113
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California494
- Maryland195
- Alabama176
- Florida145
- Arizona141
- New York122
- Massachusetts119
- Texas118
- Illinois81
- Colorado76
Recruiting studies6,230 total
- NCT05287074Enrolling by invitation
Checking timing of egg and milk allergy diagnosis in children
This study looks at how quickly children with possible egg and/or milk allergy are correctly diagnosed, and how follow-up checks affect their nutrition and growth. It may help you understand whether timely diagnosis and good monitoring could reduce problems with eating, weight, or growth.
VilniusAges 6 months–12 years - NCT05248659Enrolling by invitationPhase 2/Phase 3
Sibeprenlimab for IgA kidney disease after prior study
This trial studies sibeprenlimab to see if it can improve IgA nephropathy, a kidney inflammation condition. You may be able to join if you finished a previous related Otsuka study without major safety problems and your doctor thinks you could benefit.
Birmingham, AlabamaAges 18 years+ - NCT05162638Enrolling by invitation
Immune study in MS and healthy adults using a special tube
This study compares immune (defense system) “profiles” between people with multiple sclerosis (MS) and healthy volunteers. It involves a thoracic duct cannulation procedure and several MRIs to see how immune cells behave and whether a specific immune pattern is different in MS.
Philadelphia, PennsylvaniaAges 18–40 - NCT05075967Enrolling by invitation
Study attitudes and services among southern gay and bisexual men
This study gathers opinions and experiences from gay and bisexual men and from clinic staff in the American South. It helps researchers understand what affects HIV prevention and care, and how programs can better support people at higher risk.
Durham, North CarolinaAges 15 years+ - NCT05055804Enrolling by invitation
Study links an ELG test reading to blood glucose
This study looks at whether a new ELG test reading matches your blood sugar results in people with type 1 or type 2 diabetes. You may be asked to fast and come for two short visits so researchers can compare the tests.
Springdale, ArkansasAges 25–65 - NCT05011071Enrolling by invitation
Alberta BLOOM study for very premature newborns
This study follows babies born very early and their parents to learn about early health and development. It may help doctors better understand what babies need after a premature birth.
Calgary, AlbertaAges birth+ - NCT04988256Enrolling by invitationEarly Phase 1
Test cyclosporine versus steroids for DRESS skin reaction
This trial compares two medicines—cyclosporine and steroid treatment—for a rare, serious drug reaction called DRESS. It aims to see which treatment controls the illness more safely and effectively.
Los Angeles, CaliforniaAges 18 years+ - NCT04984772Enrolling by invitation
HIV and hepatitis B coinfection follow-up study in Europe
This study follows people who have both HIV and hepatitis B over time to better understand how the infection responds after starting treatment. Your information (and sometimes stored blood samples) helps researchers track changes from the start of therapy to about 2 years later.
Ages 16 years+ - NCT04933721Enrolling by invitationPhase 3
Continue berotralstat for people with hereditary angioedema
This study lets people who were already taking berotralstat through earlier BioCryst studies keep the treatment going. It looks at safety and ongoing benefit for preventing hereditary angioedema attacks.
OttawaAges 2 years+ - NCT04899895Enrolling by invitation
Rheumatology sample study for people starting new treatment
This study collects blood or other samples from people with rheumatology (joint/autoimmune) conditions. It looks at changes around the time you start a specific new medicine, which may help researchers understand how treatments work.
Waltham, MassachusettsAges 18 years+ - NCT04896138Enrolling by invitation
Natural history study for lung scarring patients
This study follows people who are being seen for lung scarring (also called ILD) and compares them with family members without lung scarring. It helps researchers better understand how this condition changes over time and what to look for in the future.
Charlottesville, VirginiaAges 18 years+ - NCT04886492Enrolling by invitation
NMOSD patient registry to help study future treatments
This is a registry that collects health information from adults with neuromyelitis optica spectrum disorder (NMOSD). It aims to better understand NMOSD and support future research, including studies of emerging therapies.
Waltham, MassachusettsAges 18 years+ - NCT04885959Enrolling by invitation
Study how an Asian diet affects gut bacteria and allergy risk in pregnancy
This study looks at whether eating a traditional Asian diet during pregnancy changes gut bacteria and body chemistry in a way that may lower (or change) a baby’s risk of developing allergies. You would follow the diet during pregnancy and be tracked after delivery.
Kota Bharu, KelantanAges 18–40 - NCT04677699Enrolling by invitation
Testing blood for signs of celiac disease and diabetes
This study screens children’s blood to look for signs of celiac disease and type 1 diabetes. It may help doctors understand who is developing these conditions early.
Seattle, WashingtonAges 1 day–7 years - NCT04676204Enrolling by invitation
How MS treatment “burden” may affect taking medicines
This study looks at whether the amount of MS treatment-related “burden” in the mouth and body affects how well people stick to their disease-modifying therapy. It may help doctors understand which patients are more likely to have trouble following treatment after switching or starting certain MS medicines.
Melbourne, VictoriaAges 18–99 - NCT04625049Enrolling by invitation
PET and MRI study in people with multiple sclerosis
This trial studies how certain brain immune activity relates to multiple sclerosis (MS) lesion growth and progression using PET and MRI scans. Your participation may help researchers understand disease changes over time and improve how MS is tracked.
Turku, Southwest FinlandAges 30–80 - NCT04563715Enrolling by invitation
Study on HIV prevention for at-risk Latino adults
This study looks at ways to prevent HIV in Latino adults who are at higher risk. It may help by testing HIV prevention approaches in specific local communities.
Indianapolis, IndianaAges 18 years+ - NCT04491721Enrolling by invitation
Follow-up study comparing two rituximab options in new DLBCL
This study follows people who already took part in an earlier Phase III trial to see how well two rituximab medicines work over time. It looks at outcomes like how long participants live and how long the disease stays under control, and may help confirm whether the biosimilar is comparable to the original.
BeijingAges 18–80 - NCT04415372Enrolling by invitation
MRI brain scan study for white and gray matter in MS
This study uses detailed MRI scans to look at brain “white matter” and “gray matter” changes in people with multiple sclerosis (MS). It may help researchers better understand how MS affects the brain and relates to symptoms.
Madison, WisconsinAges 18–60 - NCT04210791Enrolling by invitation
Stem cell transplant using your own cells for AL amyloidosis
This trial tests whether an autologous stem cell transplant (using your own stem cells) can help people with newly diagnosed AL amyloidosis. It may be offered to help your body reset abnormal disease-producing cells, based on your health and test results.
Nanjing, JiangsuAges 18–75 - NCT04190758Enrolling by invitation
Early arthritis study for RA, psoriatic arthritis, and psoriasis
This study looks at people with early arthritis related to rheumatoid arthritis, psoriatic arthritis, or psoriasis. Researchers want to understand how these early conditions behave and may help guide better treatment decisions.
GothenburgAges 18–80 - NCT04145401Enrolling by invitation
Long-term follow-up for a specific knee revision implant
This study tracks how well a particular knee revision implant performs over many years. It may help you by closely monitoring your knee after revision surgery and adding to long-term safety and performance data.
Englewood, ColoradoAges 21 years+ - NCT04049084Enrolling by invitation
Follow-up study for people treated with gene therapy for ADA-SCID
This is a follow-up (no new treatment) study for people who previously received a gene therapy made from their own cells for ADA-SCID. It mainly tracks long-term safety and whether a marker showing the gene change can still be found.
Los Angeles, CaliforniaAges Any age - NCT03976622Enrolling by invitation
Inflammation study in vitiligo and other skin conditions
This study looks at inflammation in people with vitiligo, psoriasis, atopic dermatitis, or alopecia areata. It aims to understand how these conditions compare, which may lead to better treatments.
Bordeaux, BordeauxAges 18–75
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,230 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,786 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.