Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,236 recruiting studies in this area right now.
By phase
- Not applicable3,144
- Phase 21,066
- Phase 1823
- Phase 1/Phase 2446
- Phase 3426
- Phase 4238
- Phase 2/Phase 393
Top conditions
- Multiple Sclerosis345
- Multiple Myeloma334
- Asthma194
- Lymphoma183
- Rheumatoid Arthritis141
- Type 1 Diabetes131
- Atopic Dermatitis129
- Systemic Lupus Erythematosus126
- Acute Lymphoblastic Leukemia123
- HIV Infections117
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 170
- Hodgkin Lymphoma67
- Leukemia64
- Rheumatoid Arthritis (RA)64
- Mantle Cell Lymphoma62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)91
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- Novartis Pharmaceuticals65
- M.D. Anderson Cancer Center63
- AstraZeneca57
- City of Hope Medical Center46
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama179
- Arizona141
- Florida141
- New York122
- Massachusetts120
- Texas119
- Illinois82
- Colorado77
Recruiting studies6,236 total
- NCT06421415Recruiting
Long-term effects of allergy shots in children
This study looks at how well allergy shots or drops work over the long term in children who received this treatment at Odense University Hospital. It aims to understand if the benefits last for years after treatment ends.
Odense, Odense CAges 4–18 - NCT04870437Recruiting
Light therapy study for kidney transplant rejection immune cells
This study looks at whether extra body light treatment (ECP) can change certain immune cells in people with a specific type of kidney transplant rejection caused by antibodies (cABMR). It’s meant to see if ECP could help manage the immune process after transplant.
BesançonAges 18 years+ - NCT05018858RecruitingPhase 1
Test stem cell infusion safety for lupus
This early-phase study tests whether an intravenous (through a vein) stem cell treatment made from donated umbilical cord tissue is safe for people with lupus. It focuses mainly on side effects and how well participants tolerate the infusion.
St John'sAges Any age - NCT05246267Recruiting
Dupilumab study for chronic sinus disease with nasal polyps
This study looks at how dupilumab (an injection medicine) helps people with chronic rhinosinusitis with nasal polyps, including how well it works across different ethnic backgrounds. You may be able to join if you’ve been diagnosed and you can get dupilumab through insurance or a patient assistance program.
The Bronx, New YorkAges 18–99 - NCT05084768Recruiting
Test blood markers to predict kidney transplant rejection
This study looks at special blood tests to help predict when kidney transplant rejection might happen. If the markers work, they could help doctors catch rejection earlier and adjust treatment sooner.
Loma Linda, CaliforniaAges 18 years+ - NCT04787822Enrolling by invitation
Follow-up for people in a lung transplant research group
This study checks long-term health and well-being in people who previously joined a lung transplant research study. It may help doctors understand long-term changes after transplant and improve future care.
Birmingham, AlabamaAges 13 years+ - NCT04871932Recruiting
Study of immune response to a COVID-19 vaccine
This trial studies how your immune system responds after a COVID-19 vaccine. It uses detailed blood tests to understand what changes happen in your immune cells and may help researchers improve future vaccines.
ShanghaiAges 18–50 - NCT05253352Recruiting
Track lymph fluid flow in arms after breast lymph node surgery
This study uses mapping tests to understand how lymph fluid drains in the arm after breast cancer surgery. It may help improve future treatments for arm swelling or drainage problems, but it is mainly for specific past surgical histories.
Boston, MassachusettsAges 18 years+ - NCT05161702Recruiting
Omega-3–based treatment to reduce inflammation signals in blood cells
This trial studies an omega-3–based approach to boost the body’s natural “inflammation-resolving” activity in certain blood immune cells. It may help people who want to see whether this strategy can improve inflammation-related biology.
Rimouski, QuebecAges 18 years+ - NCT04707872Recruiting
Study of a blood test after heart transplant
This study checks whether a special blood test can help detect heart transplant rejection or problems by comparing it to biopsy results. It may help your care team monitor your transplant with less guesswork.
Little Rock, ArkansasAges Any age - NCT05234463Recruiting
Study links complement activity to IgA kidney disease severity
This study looks at how parts of the immune system (called complement) may relate to how severe IgA kidney disease is. It may help doctors understand disease activity better, even if the study is mainly observational.
StrasbourgAges 18 years+ - NCT05136703Recruiting
Study depression treatment effects in people living with HIV
This study looks at how depression and its treatment may affect the brain and immune-related body systems in people with HIV. You may be eligible if you have depression and a well-controlled HIV viral load, and you can safely complete brain MRI scans.
Coral Gables, FloridaAges 18 years+ - NCT05136976RecruitingPhase 3
Rituximab for anti-MAG neuropathy in specific patients
This Phase 3 study tests rituximab, an antibody medicine, for people with a particular type of nerve damage called anti-MAG–related demyelinating polyneuropathy. It aims to see if rituximab improves symptoms or function in patients who are considered “good responders.”
BrestAges 18 years+ - NCT04763577Recruiting
Testing enzymes in ACE-inhibitor–related facial swelling
This trial studies what happens in the body’s enzyme system in people who get facial swelling (angioedema) from certain blood pressure medicines called ACE inhibitors. The goal is to better understand the cause and potentially guide safer treatment for future episodes.
GrenobleAges 18 years+ - NCT05054361Recruiting
Study gut immunity changes in children with type 1 diabetes
This study looks at how a type of immune cell (MAIT cells) and the gut (microbiota and gut lining) change around the time type 1 diabetes starts in children. It may help researchers understand why type 1 diabetes begins and how the gut and immune system are connected.
AntonyAges 1–15 - NCT04840355Recruiting
Monitoring safety of sintilimab in Chinese patients
This study carefully tracks how safe sintilimab is for people with cancer in real-world care. It may help your care team understand side effects and risks during treatment.
Beijing, Beijing MunicipalityAges 18–75 - NCT05098197RecruitingEarly Phase 1
Study of TIL cell therapy for advanced liver, bile, or pancreas cancer
This trial studies a treatment called TIL therapy, which uses your own immune cells grown from a tumor sample, to treat advanced cancers of the liver/bile ducts or pancreas. It’s mainly for people whose standard treatments have already failed (or none exist), and who can safely provide tumor tissue for the cell preparation.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06767306RecruitingPhase 2
SBRT radiation plus immunotherapy for limited spread melanoma
This trial tests if combining targeted radiation (SBRT) with standard immunotherapy works better for melanoma that has spread to a few spots in the body (but not the brain). It is for people who have not yet had treatment for their current spread.
Westmead, New South WalesAges 18 years+ - NCT04688736RecruitingPhase 2
Placebo vs allergy medicine to prevent transfusion reactions
This trial tests whether an allergy medicine (chlorpheniramine) can prevent allergic reactions during blood transfusions. You might be placed in either the medicine group or a placebo (inactive pill) group to compare side effects and reaction rates.
Hefei, AnhuiAges 18–65 - NCT05207657RecruitingPhase 1/Phase 2
Gene therapy for p47 form of chronic granulomatous disease
This trial tests an individualized gene therapy made from your own stem cells to help the immune system work better in p47-related chronic granulomatous disease (CGD). It’s designed for children who have serious infections or inflammation despite usual treatments and who don’t have a fully matched bone marrow donor.
LondonAges 1.9 years+ - NCT05334888Recruiting
Study how sex and gut bacteria relate to heart risk
This study follows people over time to understand how sex-related factors and gut bacteria may affect heart and blood-vessel risk. It may help researchers identify who could benefit from earlier prevention, based on personal risk patterns.
BerlinAges 18–50 - NCT05344469Recruiting
Testing new MS medicines in people with active relapsing MS
This study tests different approved “disease-modifying” MS medicines (shots and pills) in adults with relapsing multiple sclerosis that is currently active. It mainly looks at outcomes based on how newly starting—or recently started—treatments are handled for people with recent relapses and mild disability.
Albstadt, Baden-WurttembergAges 18–100 - NCT05319353RecruitingPhase 3
Maribavir for kids with CMV after transplant
This Phase 3 trial tests maribavir (an anti-CMV medicine) in children and teens who get CMV infection after a stem cell or solid organ transplant. It aims to see whether the drug is safe and well-tolerated, and whether it can reduce the virus in the body.
Wilmington, DelawareAges Up to 17 years - NCT05526950Recruiting
Check cytokine filtration for people getting double lung transplants
This study tests a method during double lung transplant surgery to remove certain immune signals (“cytokines”) that may help the transplanted lungs heal. It’s only for adults who are having a planned double lung transplant at the study sites.
Lund, Skåne CountyAges 18–80
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,236 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,675 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.