Treatment
Arginine clinical trials
We’re tracking 26 recruiting studies that include Arginine, each written for real people, not researchers, below.
Recruiting studies
- NCT02447874RecruitingPhase 1/Phase 2
Arginine treatment for children’s sickle cell pain
This early-phase study tests whether arginine can help control pain in children with sickle cell disease. You may be considered if your child is having a sickle cell pain episode that needs stronger pain medicine given through an IV.
Atlanta, GeorgiaAges 7–21 - NCT07755800Enrolling by invitation
Arginine toothpaste for gum health in periodontitis patients
This study tests whether an arginine-containing toothpaste improves gum health in people with treated periodontitis during their maintenance care. It may reduce gum inflammation and promote better bacterial balance below the gumline.
Iowa City, IowaAges 18–95 - NCT07664592RecruitingPhase 3
Comparing toothpastes for sensitive teeth
This trial tests whether a new toothpaste technology can block the tiny tubules in dentin that cause tooth sensitivity. It lasts 2 weeks and will help find better ways to treat sensitive teeth.
Porto Alegre, Rio Grande do SulAges 18–70 - NCT07573059Recruiting
Safety study of a test system for Loargys-treated patients
This study evaluates whether a new test system is safe to use in patients who are already taking Loargys (a medicine for a rare condition called ARG1-D, which affects how the body processes a protein building block called arginine). The study simply observes how the test system works in people already on this treatment.
Atlanta, GeorgiaAges birth–100 years - NCT07338682RecruitingPhase 2
L-Arginine for memory in older adults
This trial tests if L-Arginine, a natural amino acid, can improve thinking and memory in adults over 60 with mild to moderate memory problems. You may join if you have no other brain diseases or certain health conditions.
CairoAges 60 years+ - NCT07167693RecruitingPhase 1/Phase 2
Testing arginine for diabetic ketoacidosis in type 2 diabetes
This trial tests if an IV medicine called arginine hydrochloride can help manage diabetic ketoacidosis (DKA) in people with type 2 diabetes. It's for those who come to the ER with very high blood sugar and ketones.
Detroit, MichiganAges 18 years+ - NCT06054633Recruiting
L-arginine for knee osteoarthritis pain
This study tests whether L-arginine, a natural amino acid, can help with knee pain from osteoarthritis. You might be eligible if you are 40–80 years old, have moderate osteoarthritis on X-ray, and have had knee pain for at least 3 months.
Changsha, HunanAges 40–80 - NCT06808516RecruitingPhase 2
Can oxytocin spray improve sex life in people with AVP deficiency?
This study tests whether a nasal spray containing oxytocin can improve sexual well-being in people with a condition called arginine vasopressin deficiency (a problem with a hormone that controls water balance). Healthy volunteers who have mild sexual issues will also take part for comparison. Participants receive either the oxytocin spray or a placebo and fill out questionnaires about their sex life.
BaselAges 18 years+ - NCT06344442RecruitingPhase 3
Low-dose vasopressin for kidney protection after liver transplant
This trial tests whether giving a low dose of a hormone called vasopressin after a liver transplant can help prevent kidney injury. It's for adults scheduled for a planned liver transplant.
ParisAges 18 years+ - NCT06328686RecruitingEarly Phase 1
Arginine and whole brain radiation for brain metastases
This trial tests whether taking arginine (an amino acid) during whole brain radiation therapy can help people with brain metastases from any type of cancer. It looks at how the treatment affects the body and may improve outcomes.
Atlanta, GeorgiaAges 18 years+ - NCT05855330RecruitingPhase 2
Arginine treatment for kids hospitalized with COVID-19
This Phase 2 trial tests whether replacing the body’s arginine (an amino acid) can improve outcomes for children and young adults hospitalized with COVID-19. It may help the immune response, but you must meet several safety criteria to join.
Atlanta, GeorgiaAges 3–21 - NCT05306925Recruiting
Arginine supplement study for newborns after major gut surgery
This study looks at whether giving an amino-acid supplement called arginine to newborns after major bowel surgery can improve the baby’s immune response. It may help doctors understand how to support recovery after conditions like necrotizing enterocolitis or certain birth defects.
Liverpool, MerseysideAges 5 months–10 months - NCT07838493Recruiting
Nasal spray oxytocin and vasopressin effects on emotion processing
This study tests whether a nasal spray of oxytocin or vasopressin changes how healthy people pay attention to emotional faces. It may help us understand how these hormones affect social behavior.
Chengdu, SichuangAges 18–30 - NCT07568509RecruitingEarly Phase 1
Oxytocin levels in children with pituitary disease
This study measures oxytocin (a natural hormone) levels in children who have pituitary gland problems. Researchers want to understand if children with certain pituitary conditions don't make enough oxytocin, which could help guide future treatments.
Boston, MassachusettsAges 7–21 - NCT07569861Recruiting
Testing a blood marker to diagnose excessive thirst and urination
This study helps doctors figure out why some people drink and urinate excessively. Researchers will measure a hormone called copeptin in your blood after giving you fluids, to find out if your excessive drinking and urination is caused by a specific hormone problem (AVP deficiency) or something else.
BaselAges 18 years+ - NCT06789705Recruiting
MDMA for people with vasopressin deficiency
This study tests whether a low dose of MDMA, compared to a placebo, changes oxytocin levels in people with a condition called arginine vasopressin deficiency (also known as central diabetes insipidus). The goal is to understand the role of oxytocin in this condition and explore potential treatment insights.
BaselAges 18 years+ - NCT06676774RecruitingPhase 2
Does oxytocin nasal spray help people with diabetes insipidus?
This study tests if a nasal spray with oxytocin (a natural hormone) can improve emotion recognition and reduce stress-related hormone levels in people with central diabetes insipidus compared to healthy volunteers.
BaselAges 18 years+ - NCT05934318Recruiting
Arginine supplements to help prevent pregnancy complications
This study tests whether taking an arginine-based supplement during pregnancy can help lower the risk of bad pregnancy outcomes. You may be eligible if you are pregnant in the early-to-mid period and meet safety and location requirements.
KisumuAges 16–40 - NCT06860724Recruiting
Stress and blood vessel health study for adults 18-55
This study looks at how daily stress affects blood vessel function in healthy adults and those with depression. It aims to find links between emotions and physical health.
Newark, DelawareAges 18–55 - NCT06731855Recruiting
Recovery study: blood markers in newborns after intestine surgery
This study looks at blood markers in newborns after major stomach or intestine surgery. It aims to understand recovery and could help improve care for babies with similar conditions.
Liverpool, MerseysideAges Up to 5 days - NCT06483737Recruiting
Albumin for cirrhosis patients with hepatic encephalopathy
This trial tests whether giving human albumin through a vein can help people with liver cirrhosis who have confusion or drowsiness from a condition called hepatic encephalopathy. It is for patients with low albumin levels.
Shenyang, LiaoningAges 18 years+ - NCT06159608RecruitingEarly Phase 1
E-cigarette effects on blood vessels in young adults
This study looks at how e-cigarettes affect blood vessels in young adults. Researchers want to compare first-time vapers, experienced vapers, and non-vapers to see if there are differences between men and women.
Iowa City, IowaAges 18–24 - NCT06085729RecruitingPhase 1/Phase 2
Study of ADI-PEG20 with chemo for aggressive prostate cancer
This study tests a combination of three drugs—ADI-PEG20, carboplatin, and cabazitaxel—in men with aggressive variant prostate cancer that has stopped responding to hormone therapy. The goal is to see if this combination can shrink or slow the cancer.
Houston, TexasAges 18 years+ - NCT05317819RecruitingPhase 3
Test ADI-PEG 20 versus placebo for advanced liver cancer
This study tests whether ADI-PEG 20 helps people with advanced, unresectable hepatocellular carcinoma (liver cancer) who have high arginine levels. Participants get ADI-PEG 20 or a placebo to see which works better and improves outcomes.
ChanghuaAges 18–99
What Arginine is being studied for
Conditions with recruiting Arginine studies.
Common questions
- Are there clinical trials studying Arginine?
- Yes. Clin2 currently lists 26 recruiting studies that include Arginine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Arginine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Arginine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Arginine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.