Treatment
Caffeine clinical trials
We’re tracking 37 recruiting studies that include Caffeine, each written for real people, not researchers, below.
Recruiting studies
- NCT07402902Enrolling by invitation
Caffeine timing and fat burning during exercise
This trial looks at how different caffeine strategies affect how much fat you burn during exercise. If you are a healthy, active adult, this study could help you understand how caffeine might improve your workouts.
Fuenlabrada, MadridAges 18–50 - NCT05588934Recruiting
Testing the best daily caffeine dose for sleep and alertness
This study compares an adjusted caffeine plan versus a typical caffeine dose to see how it affects your sleep timing and daytime alertness. It may help find a caffeine amount that supports wakefulness without disrupting sleep.
Tucson, ArizonaAges 18–39 - NCT07738523RecruitingPhase 2/Phase 3
Caffeine and heart rate control in permanent atrial fibrillation
This trial tests whether stopping caffeine for up to two months helps control heart rate in people with permanent atrial fibrillation. If you drink at least one cup of caffeinated coffee a day, you may be able to join and help find out if giving up caffeine improves your heart rate.
Getafe, MadridAges 18–80 - NCT07641335Recruiting
Caffeine's Effects on Chess Playing and Thinking Skills
This study tests whether caffeine helps professional chess players think more clearly and play better. Researchers will measure your chess performance and mental focus after you take caffeine or a placebo.
St Louis, MissouriAges 18–50 - NCT07626437RecruitingPhase 3
Cold and Flu Symptom Relief Medicine Trial
This study tests a combination medicine containing pain reliever, caffeine, and allergy medication to help ease nasal congestion and other cold or flu symptoms. You'd take the medicine for a short period and report how well it works.
Belo Horizonte, Minas GeraisAges 18–60 - NCT07625358Recruiting
How Caffeine and Alcohol Affect Your Eyes
This study measures how caffeine and alcohol change the size of your pupils (the dark circles in your eyes). Researchers want to understand how these common substances affect your eye's natural responses, which could help with vision and neurological research.
SingaporeAges 30–50 - NCT06763172RecruitingPhase 4
Caffeine's effect on learning in healthy adults
This study uses brain scans to see how caffeine affects the way we learn from rewards and punishments. You may be eligible if you are a healthy adult who drinks a moderate amount of caffeine daily.
Charlestown, MassachusettsAges 18–45 - NCT07466732Enrolling by invitationEarly Phase 1
Caffeine and morning mental and physical performance in men
This study tests whether taking caffeine in the morning can help young men with weight-training experience think more clearly and perform better during repeated sprints. You will be asked to complete cognitive and exercise tests after taking either caffeine or a placebo.
Liverpool, MerseysideAges 18–35 - NCT07193264Recruiting
Caffeine's effect on blood health in healthy adults
This study looks at how regular or no caffeine intake affects your blood system. It aims to understand if caffeine changes blood cell counts and immune function.
Zurich, Canton of ZurichAges 18 years+ - NCT07032454Recruiting
Hand reaction speed and dexterity & caffeine dependence
This trial looks at how caffeine dependence might affect your hand reaction speed and manual dexterity. It is for healthy university students who do not have any hand problems.
Istanbul, ÜsküdarAges 18–30 - NCT06401083RecruitingPhase 4
Extra caffeine dose before removing breathing tube in preemies
This study tests if giving an extra dose of caffeine (a medicine that helps premature babies breathe) right before removing the breathing tube can make the transition easier. It is for very premature babies who have been on a ventilator for at least two days and are ready for their first try at breathing on their own.
BudapestAges Any age - NCT07570121RecruitingPhase 1
How Caffeine Moves Through Pregnancy and to the Baby
This study looks at how caffeine is absorbed and transferred to a baby during pregnancy in women at risk of early delivery. Researchers hope to understand safe caffeine use in this situation and potentially help prevent complications.
Indianapolis, IndianaAges 18 years+ - NCT07536568Recruiting
Caffeine to speed recovery after eye surgery in older adults
This study tests whether a small dose of caffeine placed under the tongue helps older adults wake up faster and feel less confused after eye surgery under general anesthesia. Researchers want to see if this simple approach can improve how quickly patients recover and reduce post-surgery agitation.
CairoAges 65 years+ - NCT07369726Recruiting
Mobilization and caffeine after cesarean
This trial tests whether getting out of bed and drinking coffee after a planned cesarean can help reduce pain and speed up recovery. It is for women who have moderate to severe pain after surgery.
Konya, KonyaAges 18–35 - NCT06712667Recruiting
Coffee and intense exercise: a caffeine metabolism study
This study looks at how coffee affects people who do intense exercise, and how their bodies process caffeine. It may help understand if coffee can improve exercise performance or recovery.
Shenzhen, GuangdongAges 18–40 - NCT06712511Recruiting
Coffee's effect on energy and caffeine breakdown
This study looks at how coffee affects your body's energy use and how quickly you process caffeine. It may help explain why coffee affects people differently.
Shenzhen, GuangdongAges 18–40 - NCT07262060RecruitingPhase 2
Preventing kidney problems in preterm babies with caffeine
This study tests whether giving caffeine to very premature babies can help protect their kidneys as they grow. We will use a special light monitor on the skin to check blood flow to the brain and kidneys.
Madison, WisconsinAges 12 hours–4 days - NCT07212803RecruitingPhase 4
Energy drinks study for young healthy adults
This study looks at how energy drinks affect your heart. It compares the effects of two different energy drinks on heart rate and other heart measures. You will have several short visits where you drink an energy drink and get your heart checked.
Stockton, CaliforniaAges 18–40 - NCT07216365RecruitingPhase 2
Caffeine dosing study for very premature babies
This study is testing different doses of caffeine to improve oxygen levels in extremely low birth weight babies born before 28 weeks. We want to see which dose works best to help their breathing.
Rochester, New YorkAges birth–6 months - NCT07022496RecruitingPhase 4
Can oral caffeine help with acute migraine attacks?
This trial tests whether taking caffeine by mouth can reduce the severity of a migraine attack when it happens. It may offer a simple, at-home option for people with different types of migraine.
CairoAges 18–60 - NCT06026163RecruitingPhase 2/Phase 3
Caffeine for breathing help in late preterm babies
This trial tests if giving caffeine to late preterm babies with breathing problems helps them need less breathing support. It could be an extra treatment alongside standard care.
Madinah, Medina RegionAges 1 day–3 days - NCT06855108RecruitingPhase 3
Caffeine for newborn brain injury after oxygen loss
This trial tests if giving caffeine to newborns who had low oxygen at birth can help protect their brains. It compares caffeine plus standard care to placebo plus standard care for moderate to severe hypoxic ischemic encephalopathy (HIE).
SaidpurAges Up to 6 hours - NCT06538584RecruitingPhase 1/Phase 2
Caffeine added to sedation for faster MRI recovery in children
This study tests whether adding caffeine to the usual sedation medicine helps children recover faster after an MRI. It looks at how quickly kids wake up and can go home.
Chicago, IllinoisAges 3–12 - NCT06518603RecruitingPhase 4
Caffeine for preventing apnea in preterm babies in Zambia
This trial tests whether giving caffeine citrate can help prevent breathing pauses (apnea) in preterm babies who are ready to stop their current caffeine treatment. It aims to see if a short course of caffeine can keep babies stable after they come off oxygen and are eating well.
Lusaka, Lusaka ProvinceAges birth–1 year
What Caffeine is being studied for
Conditions with recruiting Caffeine studies.
Common questions
- Are there clinical trials studying Caffeine?
- Yes. Clin2 currently lists 37 recruiting studies that include Caffeine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Caffeine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Caffeine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Caffeine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.