Clinical trials
Respiratory Failure clinical trials
Below are recruiting respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 210 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06501118Recruiting
Oxygen levels in ICU patients on breathing machines
This study tests whether giving a little more oxygen to ICU patients on breathing machines leads to better recovery. It compares usual oxygen levels to a more liberal target to see which is safer and more effective.
Aurora, ColoradoAges 18 years+ - NCT06989385Recruiting
Studying breathing support failure in respiratory failure
This study looks at why some patients with acute respiratory failure do not improve with non-invasive breathing support like high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV). It aims to find patterns that might predict when these treatments are not enough.
ModenaAges 18 years+ - NCT07638293Recruiting
High-Flow Oxygen Therapy Weaning Protocols for Respiratory Failure
This trial compares two different approaches to gradually reducing high-flow nasal oxygen therapy (a breathing support treatment delivered through your nose) in patients with acute respiratory failure. The goal is to find the best way to safely stop this treatment and transition you to breathing on your own.
Milan, LombardyAges 18 years+ - NCT07423338Recruiting
Monitoring breathing muscles in respiratory failure patients
This study tests a new way to monitor breathing muscles in patients who need extra oxygen or breathing support, like a mask or high-flow oxygen. It may help doctors better understand how to treat respiratory failure.
LondonAges 18 years+ - NCT03826797Recruiting
Testing breathing pressure signals in serious lung breathing failure
This study looks at how pressure readings from a breathing tube compare with whether non-invasive breathing support fails in people with sudden, severe low oxygen levels. It may help improve how clinicians spot who will need stronger breathing treatment sooner.
ModenaAges 18 years+ - NCT03642002Recruiting
Music therapy for adults on breathing machines in the ICU
This trial tests whether music therapy can improve comfort and recovery for adults who need a breathing machine (mechanical ventilation) in the ICU for at least 48 hours. It may help with stress, mood, and other ICU-related symptoms while you are in critical care.
New York, New YorkAges 18 years+ - NCT03753412Recruiting
Rehab program for adults after ICU recovery on ECMO
This trial looks at a recovery and rehabilitation approach for adults who were very sick and needed a machine called ECMO to support breathing and heart function. It may help people regain strength and function after a severe ICU illness.
LondonAges 18 years+ - NCT04183660Recruiting
MOBYBOX monitoring study for temporary heart-lung support
This is a post-market “real-world” monitoring study for a heart-lung machine (extracorporeal cardiopulmonary support/ECMO) used during very serious heart and/or lung failure. It aims to track safety and performance in patients who need rescue breathing or circulation support.
Hanover, Lower SaxonyAges 18–80 - NCT05089695Recruiting
Compare noninvasive breathing supports for breathing failure
This trial compares different ways to help you breathe without a breathing tube: helmet NIV, CPAP, or high-flow nasal oxygen. It aims to see which support works best for people who have sudden (acute) low oxygen levels.
RomeAges 18 years+ - NCT05150483Recruiting
Study of a blood test in new severe breathing failure
This trial looks at how a test might help evaluate adults who come to the emergency room with a brand-new, sudden breathing problem that needs high-flow oxygen. It may help doctors identify what’s going on faster and guide care in the early hours.
Athens, AtticaAges 18 years+ - NCT06357780Recruiting
Comparing two breath-timing methods for breathing masks in adults
This study compares two ways of timing a breathing mask's support to match your own breaths. If you're in the ICU or ER and need help breathing for at least 2 more hours, this trial may test which method works better.
IzmirAges 18 years+ - NCT06374589Recruiting
Closing the loop on oxygen use during high flow therapy
This trial tests a system that automatically adjusts oxygen levels for patients receiving high flow oxygen therapy. The goal is to see if it can keep oxygen levels in a safe range better than usual care.
IstanbulAges 18 years+ - NCT06671015Recruiting
Comparing breathing support methods after a breathing tube is removed in people with heart failure
This study compares two types of breathing support—a high-flow nasal cannula and noninvasive ventilation—to see which one better prevents the need for re-inserting a breathing tube in people with systolic heart failure who are at high risk for breathing problems after the tube is removed.
New Haven, ConnecticutAges 18 years+ - NCT06716463Recruiting
Predicting breathing support failure with wearable monitoring
This study tests if a wearable chest monitor can predict when breathing support (like a mask or nasal prongs) might stop working, so doctors can act faster. It is for hospital patients who need help breathing but are not on a breathing tube.
Toronto, OntarioAges 18 years+ - NCT06952816Recruiting
Testing EMILY AI for respiratory failure
This study tests a new AI device (EMILY) that helps monitor breathing problems like acute respiratory failure. You may join if you are in a hospital for respiratory care and meet certain health criteria.
MadridAges 18 years+ - NCT06988111Recruiting
Breathing support after major surgery
This trial tests two types of non-invasive breathing help (NIV and HVNI) for patients who develop serious breathing problems within two days after major surgery. It aims to see which method works better to avoid needing a breathing tube.
Asyut, AssuitAges 18 years+ - NCT07161271Recruiting
Study on a low-flow CO2 removal device for breathing failure
This study looks back at medical records of people who used a special device (ECCO2R) in the ICU to help remove carbon dioxide from the blood. The goal is to see if the device is safe and works well for patients with breathing problems.
Hong KongAges 18 years+ - NCT07521254Recruiting
High-flow oxygen and breathing support for acute respiratory failure
This trial tests whether high-flow oxygen delivered through the nose, combined with non-invasive breathing support (a mask that helps you breathe without a tube down your throat), can help patients with sudden severe breathing problems. The goal is to improve oxygen levels and avoid the need for a breathing tube.
Minya, Minya GovernorateAges 18 years+ - NCT06938217Enrolling by invitation
Low-flow ECMO for adults with severe breathing failure
This study tests whether a gentler, low-blood-flow version of ECMO (a machine that helps oxygenate blood outside the body) is safe and effective for adults with very severe breathing failure. It is for patients who are already on a breathing machine and have very low oxygen levels despite that support.
San Antonio, TexasAges 18–65 - NCT04912960Recruiting
PEEP breathing support for adults with acute lung failure
This trial studies whether a specific breathing setting called PEEP can help adults whose lungs are failing and who need a breathing machine. Doctors will compare outcomes in patients who fit this critical illness pattern and are safe for the required positioning and ventilator settings.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT05347563Recruiting
Using a chest sensor to improve ventilation in sick children
This trial tests whether a special chest sensor (called electrical impedance tomography, or EIT) can help doctors distribute breathing support more effectively in children with sudden breathing failure. It may help optimize ventilation while the child is being monitored in intensive care or during anesthesia.
Bron, RhoneAges birth–18 years - NCT06901050Recruiting
A study of FAST HUGS care for ICU patients with low oxygen
This trial tests a special care bundle called 'FAST HUGS' to see if it helps people in the ICU with low oxygen levels get better sooner. It focuses on patients in the Chest Intensive Care Unit who have trouble getting enough oxygen.
ErzurumAges 18–100 - NCT07279831Recruiting
Brain-lung interaction study in acute respiratory failure
This trial looks at how the lung and brain communicate during serious breathing problems. If you are in the ICU with a new breathing issue and need high-flow oxygen therapy, researchers want to study your brain and lung activity together.
ParisAges 18 years+ - NCT06479421Recruiting
AI study to personalize care for sudden breathing failure
This study is developing an artificial intelligence (AI) tool to help doctors choose the best treatment for people with sudden breathing failure. It compares patients who need breathing support to those who do not, to find patterns that improve care.
Seoul, GangnamAges 18 years+
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Respiratory Failure trials by city
Studies with a site in or near these metro areas.
Respiratory Failure trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for respiratory failure?
- Yes. Clin2 currently lists 210 recruiting respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.