Treatment
Direct Oral Anticoagulant clinical trials
We’re tracking 36 recruiting studies that include Direct Oral Anticoagulant, each written for real people, not researchers, below.
Recruiting studies
- NCT07520890Recruiting
Bleeding Risk During Oral Biopsies in Patients on Blood Thinners
This study looks at whether patients taking certain blood-thinning medications (DOACs) have more bleeding during oral biopsies—small tissue samples taken from the mouth. Understanding this helps doctors know how to safely care for patients on these medications.
Pisa, PiAges 18 years+ - NCT04262492Recruiting
Registry of adults with APS on blood thinners
This study keeps an international registry of people with antiphospholipid syndrome (APS) who are taking direct oral blood thinners. It may help doctors better understand how APS patients do over time and improve future care, even if you’re not asked to change treatment.
NancyAges Any age - NCT04660747Recruiting
Anticoagulant medication choices for cerebral venous thrombosis
This study looks at people with cerebral venous thrombosis who were treated with blood thinners taken by mouth (or started within the first 30 days). It uses observational data to understand how these treatments are used and what outcomes may follow.
Amsterdam, North HollandAges 18 years+ - NCT06194617Recruiting
Rivaroxaban for older Chinese patients with blood clots in lungs
This trial tests whether a blood thinner called rivaroxaban (a pill) works well for older Chinese patients who have had a blood clot in their lungs and are now on long-term treatment. It aims to see if it's safe and effective for this group.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06322953RecruitingPhase 3
Timing to restart blood thinners after head injury bleeding
This trial looks at when it is safest to restart blood thinners after a traumatic brain bleed. It compares restarting at 4 weeks versus 8 weeks in people on blood thinners before their injury.
Plymouth, DevonAges 18 years+ - NCT06869811Recruiting
Stroke prevention after failed blood thinners
This study is for people who had a stroke despite taking blood thinners for atrial fibrillation. It tests if adding a procedure to close the left atrial appendage (a small pouch in the heart) to your blood thinner is better than just taking the blood thinner alone to prevent another stroke.
Barcelona, BarcelonaAges 18–95 - NCT06947707Recruiting
Blood thinners for brain blood clot in Chinese patients
This trial tests two blood thinner medicines, edoxaban and rivaroxaban, in Chinese patients with a blood clot in a brain vein (cerebral venous thrombosis). It aims to see if these medicines are safe and work well.
Beijing, Beijing MunicipalityAges 18–80 - NCT07242326Enrolling by invitation
Blood Thinner Dose Check for Older Adults With AFib
This study looks at whether older adults with atrial fibrillation are taking the right dose of their blood thinner medicine. It aims to improve how doctors prescribe these medications in primary care.
Ordu, OrduAges 65 years+ - NCT05387954RecruitingPhase 3
PFO closure or blood thinners after stroke in ages 60–80
This trial studies the best way to prevent another stroke after a recent stroke in people ages 60 to 80 who have a “PFO” heart connection. It compares closing the PFO vs taking mouth blood-thinners or antiplatelet medicine, based on what your doctors determine is safest for you.
AmiensAges 60–80 - NCT05723926Recruiting
Carotid implants to help prevent stroke repeat in atrial fibrillation
This trial tests whether placing a carotid implant can reduce the chance of having another stroke in people with atrial fibrillation who are already taking blood thinners. It aims to prevent stroke recurrence while you continue prescribed anticoagulation.
Rockford, IllinoisAges 18 years+ - NCT06823466Recruiting
Stroke study for patients on blood thinners
This study looks at people who had a stroke while taking blood thinners (anticoagulants) for an irregular heartbeat. It aims to learn more about these strokes and how to better prevent them in the future.
ZagrebAges 18 years+ - NCT06957366Recruiting
Managing Blood Thinners Before High-Risk Surgery
This study looks at how to safely manage your blood thinner (DOAC) around the time of a planned, high-bleed-risk surgery or procedure involving a spinal needle. The goal is to find the best way to stop and restart your medication to prevent bleeding and clotting problems.
Hartford, ConnecticutAges 18 years+ - NCT04874428RecruitingPhase 1
Blood thinner pills in people with mild-to-moderate cirrhosis
This early study tests whether the blood thinner pills rivaroxaban and apixaban can be used safely in people with liver cirrhosis that is not too severe. It may help doctors understand the safest way to prevent or treat blood clots in this group.
BernAges 18 years+ - NCT04284839RecruitingPhase 3
Blood thinner pills vs warfarin after heart surgery
This trial compares two ways to prevent blood clots after open heart surgery: a “direct oral” blood thinner pill versus warfarin (a vitamin K antagonist). It may help find the safest and most effective option for people who develop atrial fibrillation after surgery.
Fitzroy, VictoriaAges 18 years+ - NCT07288489RecruitingPhase 3
A study on VMX-C001 for urgent surgery while on blood thinners
This trial tests a drug called VMX-C001 to quickly reverse the effects of certain blood thinners (Factor Xa inhibitors) in people who need urgent surgery with a high risk of bleeding. It compares VMX-C001 to standard care to see which is more effective at helping blood clot normally.
Chandler, ArizonaAges 18 years+ - NCT05169242Recruiting
Preventing bleeding after colonoscopy using preventive clip placement
This trial tests whether placing small “preventive clips” during colonoscopy can reduce bleeding afterward in people who take blood thinners (DOACs). It may help lower the chance of bleeding after polyp removal or biopsy during a scheduled colonoscopy.
Shatin, New TerritoriesAges 18 years+ - NCT05028777Recruiting
People with a heart clot who can join a hospital record study
This study looks at people age 18+ who were found to have a blood clot in the left side of the heart (left ventricular thrombus) on scans between 2013 and 2020. It will compare how different blood-thinner medicines were used and what outcomes occurred.
BernAges 18 years+ - NCT06482333Recruiting
When to restart blood thinners after polyp removal
This trial looks at the best time to restart direct oral anticoagulants (blood thinners) after having polyps removed during a colonoscopy. It aims to find a balance between preventing bleeding and reducing the risk of blood clots.
Hong KongAges 40 years+ - NCT06571149RecruitingPhase 4
Blood thinners and clot-busting drugs for stroke
This trial tests whether giving a clot-dissolving medicine (alteplase or tenecteplase) is safe and effective for people who have had a stroke and are taking a blood thinner (DOAC) like apixaban or rivaroxaban. It aims to see if this treatment can still be given within a few hours of the stroke.
EisenstadtAges 18 years+ - NCT04700826RecruitingPhase 4
Preventing stroke, death, and memory decline in atrial fibrillation
This trial looks at ways to help people with atrial fibrillation lower their risk of stroke, premature death, and worsening memory. It may help by identifying which prevention approach works best for a broader community of patients.
Birmingham, West MidlandsAges 55–73 - NCT04977076Recruiting
Stopping versus continuing blood thinner during heart catheter procedures
This study compares whether you should temporarily stop your blood thinner (DOAC) or keep taking it when you have an elective heart catheter test or procedure (coronary angiography or PCI). It aims to see which approach is safer and better for preventing bleeding and clotting around the procedure.
Heerlen, LimburgAges 18 years+ - NCT05070169Recruiting
Early surgery for hip fractures in people on blood thinners
This study looks at whether fixing a hip fracture sooner is better for people who take a direct oral anticoagulant (DOAC) blood thinner. It compares early surgery versus delayed surgery in people whose delay is specifically from the blood thinner.
ViennaAges 18 years+ - NCT05198960RecruitingPhase 3
Blood thinner drugs vs aspirin to prevent clot problems
This trial compares apixaban or rivaroxaban (blood thinners) against aspirin to prevent future clot-related complications in people with certain bone marrow diseases (PV, ET, or pre-PMF) that have a specific JAK2 mutation. It may help lower the risk of clots, but it also carefully considers bleeding risk.
AngersAges 18 years+ - NCT05498428RecruitingPhase 2
Amivantamab for advanced lung cancer with EGFR mutations
This Phase 2 study tests amivantamab (an antibody medicine) in people with advanced or metastatic non-small cell lung cancer that has specific EGFR gene changes. It may help shrink tumors or control cancer when standard curative treatments aren’t possible.
La Jolla, CaliforniaAges 18 years+
What Direct Oral Anticoagulant is being studied for
Conditions with recruiting Direct Oral Anticoagulant studies.
Common questions
- Are there clinical trials studying Direct Oral Anticoagulant?
- Yes. Clin2 currently lists 36 recruiting studies that include Direct Oral Anticoagulant, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Direct Oral Anticoagulant trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Direct Oral Anticoagulant an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Direct Oral Anticoagulant or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.