Treatment
Direct Oral Anticoagulants clinical trials
We’re tracking 35 recruiting studies that include Direct Oral Anticoagulants, each written for real people, not researchers, below.
Recruiting studies
- NCT04660747Recruiting
Anticoagulant medication choices for cerebral venous thrombosis
This study looks at people with cerebral venous thrombosis who were treated with blood thinners taken by mouth (or started within the first 30 days). It uses observational data to understand how these treatments are used and what outcomes may follow.
Amsterdam, North HollandAges 18 years+ - NCT07520890Recruiting
Bleeding Risk During Oral Biopsies in Patients on Blood Thinners
This study looks at whether patients taking certain blood-thinning medications (DOACs) have more bleeding during oral biopsies—small tissue samples taken from the mouth. Understanding this helps doctors know how to safely care for patients on these medications.
Pisa, PiAges 18 years+ - NCT06869811Recruiting
Stroke prevention after failed blood thinners
This study is for people who had a stroke despite taking blood thinners for atrial fibrillation. It tests if adding a procedure to close the left atrial appendage (a small pouch in the heart) to your blood thinner is better than just taking the blood thinner alone to prevent another stroke.
Barcelona, BarcelonaAges 18–95 - NCT07242326Enrolling by invitation
Blood Thinner Dose Check for Older Adults With AFib
This study looks at whether older adults with atrial fibrillation are taking the right dose of their blood thinner medicine. It aims to improve how doctors prescribe these medications in primary care.
Ordu, OrduAges 65 years+ - NCT06947707Recruiting
Blood thinners for brain blood clot in Chinese patients
This trial tests two blood thinner medicines, edoxaban and rivaroxaban, in Chinese patients with a blood clot in a brain vein (cerebral venous thrombosis). It aims to see if these medicines are safe and work well.
Beijing, Beijing MunicipalityAges 18–80 - NCT06322953RecruitingPhase 3
Timing to restart blood thinners after head injury bleeding
This trial looks at when it is safest to restart blood thinners after a traumatic brain bleed. It compares restarting at 4 weeks versus 8 weeks in people on blood thinners before their injury.
Plymouth, DevonAges 18 years+ - NCT04262492Recruiting
Registry of adults with APS on blood thinners
This study keeps an international registry of people with antiphospholipid syndrome (APS) who are taking direct oral blood thinners. It may help doctors better understand how APS patients do over time and improve future care, even if you’re not asked to change treatment.
NancyAges Any age - NCT05387954RecruitingPhase 3
PFO closure or blood thinners after stroke in ages 60–80
This trial studies the best way to prevent another stroke after a recent stroke in people ages 60 to 80 who have a “PFO” heart connection. It compares closing the PFO vs taking mouth blood-thinners or antiplatelet medicine, based on what your doctors determine is safest for you.
AmiensAges 60–80 - NCT06823466Recruiting
Stroke study for patients on blood thinners
This study looks at people who had a stroke while taking blood thinners (anticoagulants) for an irregular heartbeat. It aims to learn more about these strokes and how to better prevent them in the future.
ZagrebAges 18 years+ - NCT05723926Recruiting
Carotid implants to help prevent stroke repeat in atrial fibrillation
This trial tests whether placing a carotid implant can reduce the chance of having another stroke in people with atrial fibrillation who are already taking blood thinners. It aims to prevent stroke recurrence while you continue prescribed anticoagulation.
Rockford, IllinoisAges 18 years+ - NCT06957366Recruiting
Managing Blood Thinners Before High-Risk Surgery
This study looks at how to safely manage your blood thinner (DOAC) around the time of a planned, high-bleed-risk surgery or procedure involving a spinal needle. The goal is to find the best way to stop and restart your medication to prevent bleeding and clotting problems.
Hartford, ConnecticutAges 18 years+ - NCT04874428RecruitingPhase 1
Blood thinner pills in people with mild-to-moderate cirrhosis
This early study tests whether the blood thinner pills rivaroxaban and apixaban can be used safely in people with liver cirrhosis that is not too severe. It may help doctors understand the safest way to prevent or treat blood clots in this group.
BernAges 18 years+ - NCT04284839RecruitingPhase 3
Blood thinner pills vs warfarin after heart surgery
This trial compares two ways to prevent blood clots after open heart surgery: a “direct oral” blood thinner pill versus warfarin (a vitamin K antagonist). It may help find the safest and most effective option for people who develop atrial fibrillation after surgery.
Fitzroy, VictoriaAges 18 years+ - NCT07863115Recruiting
Preventing blood clots after leg injury with a cast
This study looks at a simple checklist to see who is at risk for blood clots after a leg injury that requires a cast or brace. It also checks how well people follow blood-thinning medication to prevent these clots.
MonastirAges 18 years+ - NCT06362343Recruiting
Personalized dosing study for Xa inhibitor blood thinners
This study looks at how the body processes a certain type of blood thinner (Xa factor inhibitors) to help doctors find the right dose for each person. If you have a blood clot in your lungs and are on long-term treatment, this trial might help improve your care.
Beijing, Beijing MunicipalityAges 18–120 - NCT06556446Recruiting
Clot-busting drug after stroke if on blood thinner
This study looks at whether giving a clot-busting medicine (IV thrombolysis) is safe and effective for people who have had a stroke and also recently took a direct oral anticoagulant (DOAC). If you've taken a DOAC in the last 48 hours, this trial may help doctors decide the best treatment for you.
InnsbruckAges 18 years+ - NCT05028777Recruiting
People with a heart clot who can join a hospital record study
This study looks at people age 18+ who were found to have a blood clot in the left side of the heart (left ventricular thrombus) on scans between 2013 and 2020. It will compare how different blood-thinner medicines were used and what outcomes occurred.
BernAges 18 years+ - NCT05070169Recruiting
Early surgery for hip fractures in people on blood thinners
This study looks at whether fixing a hip fracture sooner is better for people who take a direct oral anticoagulant (DOAC) blood thinner. It compares early surgery versus delayed surgery in people whose delay is specifically from the blood thinner.
ViennaAges 18 years+ - NCT07559942Recruiting
Apiban to Help Dialysis Fistulas Mature Successfully
This trial tests whether a blood-thinner medication called apixaban (Apiban) helps arteriovenous fistulas—surgically created connections in the arm for dialysis—develop and work better. If it helps fistulas mature faster and more reliably, it could reduce complications and improve treatment for kidney failure patients.
Lahore, Punjab ProvinceAges 18 years+ - NCT07333144Recruiting
Bleeding from the gut while on blood thinners
This study collects information from patients who come to the emergency room with gastrointestinal bleeding while taking certain newer blood thinners. It aims to better understand and manage this type of bleeding.
StrasbourgAges 18 years+ - NCT07309848Recruiting
Hip fracture surgery timing and blood transfusion risk on DOACs
This study looks at whether the timing of hip fracture surgery affects the need for blood transfusions in patients taking blood thinners (DOACs). It might help guide better care for people on these medications.
AlmeloAges Any age - NCT07288489RecruitingPhase 3
A study on VMX-C001 for urgent surgery while on blood thinners
This trial tests a drug called VMX-C001 to quickly reverse the effects of certain blood thinners (Factor Xa inhibitors) in people who need urgent surgery with a high risk of bleeding. It compares VMX-C001 to standard care to see which is more effective at helping blood clot normally.
Chandler, ArizonaAges 18 years+ - NCT07159399Enrolling by invitation
Pharmacist-led education to help patients take blood thinners
This trial tests if talking with a pharmacist helps people with atrial fibrillation remember to take their blood thinner medicine correctly. It may improve stroke prevention.
TaipeiAges 18 years+ - NCT04700826RecruitingPhase 4
Preventing stroke, death, and memory decline in atrial fibrillation
This trial looks at ways to help people with atrial fibrillation lower their risk of stroke, premature death, and worsening memory. It may help by identifying which prevention approach works best for a broader community of patients.
Birmingham, West MidlandsAges 55–73
What Direct Oral Anticoagulants is being studied for
Conditions with recruiting Direct Oral Anticoagulants studies.
Common questions
- Are there clinical trials studying Direct Oral Anticoagulants?
- Yes. Clin2 currently lists 35 recruiting studies that include Direct Oral Anticoagulants, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Direct Oral Anticoagulants trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Direct Oral Anticoagulants an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Direct Oral Anticoagulants or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.