Clinical trials
Acute Pain clinical trials
Below are recruiting acute pain clinical trials, each written for real people, not researchers. We’re tracking 202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07511816RecruitingPhase 2
Pain Relief Study After Wisdom Tooth Removal
This study tests a new pain medication (LY4515100) in people recovering from wisdom tooth extraction surgery. The goal is to see if it reduces pain better than current options after the procedure.
Salt Lake City, UtahAges 18–40 - NCT07411417Recruiting
Acupressure for pain and lung function after chest surgery
This trial tests if acupressure can help reduce pain and improve lung function after a first-time chest surgery. It may offer a non-drug way to support recovery.
IstanbulAges Any age - NCT05906134RecruitingPhase 1/Phase 2
Pain control plan after minimally invasive esophagus surgery
This trial tests a pain-control method (using an epidural/nerve pain-block through the back, called neuraxial anesthesia) for people having minimally invasive esophagus removal surgery. It may help reduce pain after surgery and improve comfort during recovery.
Seattle, WashingtonAges 18 years+ - NCT05905146Recruiting
Personalized opioid plan to shorten treatment time
This trial tests whether a personalized medication plan can help patients with short-term, non-cancer muscle or joint pain need strong opioid medicine for a shorter time. It’s aimed at improving how long treatment lasts while still managing pain.
LilleAges 18 years+ - NCT05335070RecruitingPhase 2
Study to reduce pain from wisdom tooth extractions
This Phase 2 study tests ways to reduce pain during and after wisdom (back) tooth extractions done with IV sedation. It may help you have a more comfortable experience by improving how pain is managed after the procedure.
Newark, New JerseyAges 18–64 - NCT03446456RecruitingPhase 1/Phase 2
Vasopressin and pain perception study
This trial tests whether vasopressin, a nasal spray, changes how your brain processes pain. You will receive either the spray or a placebo and have an MRI scan to see brain activity.
Baltimore, MarylandAges 18–65 - NCT07732556Recruiting
Nerve block comparison for shingles pain relief
This trial compares two different nerve blocks (MTP and ESP) to see which works better for treating shingles pain in the chest or back. It could help you if you have moderate to severe shingles pain that started within the last 30 days.
Tanta, El-GharbiaAges 21–60 - NCT07680998Recruiting
Pain monitor device for recovery after day surgery
This trial tests a device that monitors pain and recovery after outpatient surgery. It may help manage pain more safely and improve your comfort after you go home.
Nîmes, GardAges 18 years+ - NCT07706348RecruitingPhase 1/Phase 2
Pain relief with ondansetron and lidocaine after abdominal cancer surgery
This trial tests if rinsing the belly with ondansetron (a nausea medicine) and lidocaine (a numbing medicine) during surgery can reduce pain afterward. It is for people having major lower abdominal cancer surgery who are otherwise healthy.
AsyutAges 20–70 - NCT06669884Recruiting
New ECG method to quickly sort chest pain in ER
This study tests a new ECG-based technology that may help doctors more quickly sort out the cause of your chest pain in the emergency room. If you have chest pain that needs checking, this tool could help decide how urgent your care is.
Jinan, ShandongAges 18 years+ - NCT06320041RecruitingPhase 4
Oliceridine for pain after orthopedic surgery
This trial tests a new painkiller called oliceridine for moderate to severe pain after orthopedic surgery. It may help you recover more comfortably with fewer side effects.
Yiwu, ZhejiangAges 18–100 - NCT06411197Recruiting
Walking and muscle pain in healthy adults
This study looks at how people walk and how muscles in the legs may feel sore. It is for healthy adults to understand normal movement patterns.
Aalborg, North DenmarkAges 18–45 - NCT06184126Recruiting
Virtual reality for sickle cell pain in the emergency room
This trial tests whether using a virtual reality (VR) headset, along with your usual pain treatment, can help reduce pain during a sickle cell crisis. It is for adults with sickle cell disease who are in the emergency department and receiving IV opioids for a vaso-occlusive crisis.
Baltimore, MarylandAges 18 years+ - NCT04880707RecruitingPhase 2
Pain medication options for lower wisdom tooth removal
This study compares pain-medication approaches during and after removing at least one lower impacted wisdom tooth (a tooth that’s stuck). It may help find a safer or more effective way to control dental pain after surgery.
Newark, New JerseyAges 18 years+ - NCT07824908Recruiting
Numbing medicine and pain after keyhole appendix removal
This study looks at whether the place where the appendix is taken out during keyhole surgery and the use of numbing medicine can help reduce pain after the operation. If you're having this emergency surgery, you may have less pain afterward.
Diyarbakır, KayapınarAges 18 years+ - NCT07781930Recruiting
Comparing two pain blocks after kidney laparoscopy
This study compares two types of pain-relieving injections given during kidney surgery to see which one works better. It may help reduce pain after surgery and improve recovery.
CairoAges 18–40 - NCT06865378Enrolling by invitation
Breathing gas and nausea after hysterectomy study
This study looks at whether levels of carbon dioxide in your breath and blood flow measurements during surgery can help predict nausea, vomiting, or pain after a hysterectomy. It may help doctors better manage your recovery.
IstanbulAges 20–65 - NCT07615816Recruiting
Medical massage therapy for active-duty service members with recent lower back pain
This study tests whether massage therapy can help active-duty service members who have had lower back pain for 1–3 months. Researchers want to see if massage reduces pain and improves function.
Joint Base Lewis McChord, WashingtonAges 18–64 - NCT07846722Recruiting
Comparing two medicines to reduce pain medicine use after laparoscopic hysterectomy
This study compares two drugs, esmolol and dexmedetomidine, to see which one better reduces the need for strong painkillers after laparoscopic hysterectomy. It may help you manage pain with fewer opioids.
AthensAges 20–70 - NCT06306183Recruiting
Vitamin C for pain relief after an ER visit
This trial tests whether a high dose of vitamin C can help reduce pain for people who come to the emergency department with new muscle or bone pain. If you qualify, you will receive vitamin C or a placebo and track your pain over time.
Ottawa, OntarioAges 18 years+ - NCT04166877RecruitingPhase 4
Magnesium drip to reduce pain in ICU trauma patients
This trial tests whether a magnesium infusion can better control pain in adults who have serious injuries and need intensive care. It compares magnesium as part of pain treatment to standard pain care to see if pain improves and stays controlled.
Sacramento, CaliforniaAges 18 years+ - NCT03695887RecruitingEarly Phase 1
Disposable nitrous oxide for pain during burn dressing changes
This early-stage study tests whether using disposable nitrous oxide canisters can better control pain when you need burn dressing changes. It may help by making dressing changes more comfortable, but eligibility depends on your burn size, health, and breathing ability.
Winnipeg, ManitobaAges 18 years+ - NCT06774274RecruitingPhase 4
Ketamine for pain after major orthopedic surgery: drip vs. pump
This study tests two ways of giving a medicine called ketamine to control pain after major bone or joint surgery. One method is a steady infusion (drip) through a vein, and the other is a patient-controlled pump (PCA) that lets you press a button for more medicine when you need it.
Medellín, AntioquiaAges 18 years+ - NCT07515885Recruiting
Electroacupuncture for Shingles Pain Relief
This study tests whether electroacupuncture (a form of acupuncture with mild electrical stimulation) can reduce pain from shingles (herpes zoster), a viral infection that causes painful skin rashes. Researchers will also measure certain markers in your blood to understand how the treatment works.
Hangzhou, ZhejiangAges 20–80
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Common questions
- Are there clinical trials for acute pain?
- Yes. Clin2 currently lists 202 recruiting acute pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.