Clinical trials
Acute Pain clinical trials
Below are recruiting acute pain clinical trials, each written for real people, not researchers. We’re tracking 202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04811209Recruiting
Testing better pain control and recovery after orthopedic surgery
This trial looks at how well a pain-control plan works after certain orthopedic surgeries and how it affects recovery and patient-reported outcomes. It may help determine what level of pain relief is meaningful to patients after surgery.
Toronto, OntarioAges 18–80 - NCT05873894Recruiting
Testing pain changes during brain surgery under anesthesia
This trial studies how pain levels change during planned brain surgery while you are fully asleep, using special brain-monitoring recordings. The goal is to better understand acute pain signals during general anesthesia, which may help anesthesiologists manage pain more effectively.
ValenciaAges 18 years+ - NCT07845071RecruitingPhase 3
Cebranopadol for acute pain after surgery or injury
This study tests an investigational medication called cebranopadol to see if it safely and effectively relieves acute (short-term) pain after surgery or from a muscle or bone injury. It may offer a new option for people who need relief from moderate to severe pain.
Phoenix, ArizonaAges 18–75 - NCT07494214RecruitingPhase 1
Study on MDMA for pain relief in healthy people
This trial tests if a single dose of MDMA can reduce pain caused by heat or pressure in healthy volunteers. It aims to see if MDMA might help with certain types of pain that are hard to treat.
BaselAges 18–75 - NCT06933303Recruiting
Distraction for pain in children with burns
This trial tests if using a kaleidoscope can help distract children aged 7-12 from pain during burn dressing changes, in a setting where pain medicine is not usually given. The goal is to see if this simple tool can reduce pain without extra medication.
Empangeni, KwaZulu-NatalAges 7–12 - NCT07164677Recruiting
Nerve block for pain after open-heart surgery
This study tests a nerve block (an injection near the back muscles) to see if it helps control pain after open-heart surgery. It might be a good option if you are having planned heart surgery through a cut in the middle of your chest.
SamsunAges 18–80 - NCT07805928Recruiting
A guided pain plan after rib remodeling surgery
This study tests a step-by-step pain management plan guided by your pain scores after rib remodeling surgery. The plan uses a mix of medications to reduce pain safely and may help you recover with less discomfort.
BogotáAges 18–55 - NCT07311369RecruitingPhase 2
Testing a new pain tablet after abdominal surgery
This trial tests a new pain tablet (HL-1186) for people having abdominal surgery. It aims to see if the tablet is safe and works well to manage pain after the operation.
Changsha, HunanAges 18–75 - NCT07380789Recruiting
Managing acute chest pain after battle injuries
This study is testing better ways to manage severe chest pain after combat injuries in Ukraine. If you have chest pain from battle and are 18 or older, it may help find a treatment that works for you.
RivneAges 18–60 - NCT06960317Recruiting
Numbing injection for IUD placement pain
This study tests whether a numbing injection (lidocaine) in the cervix can reduce pain during IUD placement. It's for women who have never had a vaginal birth and are getting their first IUD.
La Jolla, CaliforniaAges 18–50 - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT07499024Recruiting
TWIST score for testicular torsion in adults with scrotal pain
This study checks how well a scoring tool (TWIST) can tell if testicular torsion is likely in adults with sudden scrotal pain. If you have sudden pain in your scrotum, you may be eligible to help test this tool in the emergency room.
Linköping, Östergötland CountyAges 18–40 - NCT06837831Recruiting
Mepilex Lite Dressing for radiation skin damage on anal area
This trial tests a special wound dressing (Mepilex Lite) to treat skin burns from radiation therapy in patients with rectal cancer. It may help heal the skin around the anal canal more comfortably.
Jinan, ShandongAges 18 years+ - NCT06804278Recruiting
Spectral CT for diagnosing heart inflammation in chest pain
This study uses a special CT scan (called spectral CT) to look for inflammation of the heart muscle or other heart problems in people who come to the hospital with sudden chest pain. The goal is to see if this scan can help doctors diagnose the cause of your chest pain more accurately.
BolognaAges 18 years+ - NCT06745453Recruiting
Nerve block for back pain in the ER
This trial tests whether a numbing injection near your spine can quickly relieve sudden back pain that has lasted less than six weeks. If it works, it could be a fast, non-opioid option during an ER visit.
Chicago, IllinoisAges 18 years+ - NCT07262944Recruiting
Pain block study for ear surgery with rib cartilage
This study tests a pain-blocking injection during ear surgery to see if it helps reduce pain after the operation. It is for teenagers having ear reconstruction with rib cartilage at a specific hospital.
SeoulAges 13–18 - NCT07826650Recruiting
How acute pain affects sleep in people with insomnia
This study looks at how a short-term (acute) pain affects sleep quality in people who suffer from insomnia compared to healthy sleepers. Participation may help researchers understand the link between pain and sleep problems.
Hong KongAges 18–60 - NCT05579496Recruiting
Rebooting infant pain care using skin-to-skin contact
This trial tests how skin-to-skin contact affects pain and brain activity in premature babies during a routine heel prick. It may help find better ways to manage pain for infants in the NICU.
Toronto, OntarioAges 6 months–8 months - NCT04849455RecruitingPhase 4
Nerve-block catheters plus spinal morphine for liver surgery pain
This trial tests whether placing pain-relief catheters near the back muscle plus giving morphine into the spinal fluid can improve comfort during and after liver surgery. It may help reduce the need for stronger opioid pain medicines afterward.
San Diego, CaliforniaAges 18 years+ - NCT07831096Recruiting
Nerve block comparison for shoulder surgery pain relief
This study compares two types of nerve blocks to see which one provides better pain relief after outpatient shoulder surgery. Participants will receive one of the two blocks, and the study will track their pain and recovery.
Varese, ItalyAges 18 years+ - NCT07778069Enrolling by invitation
Virtual reality for children having joint steroid injections
This study tests whether using virtual reality (VR) during a steroid joint injection helps children feel less pain and anxiety. If it works, it could make the procedure easier for patients from 5 to 17 years old.
Columbus, OhioAges 5–17 - NCT07698665Recruiting
Ketamine vs dexmedetomidine in scalp block for brain tumor surgery
This trial compares two medicines, ketamine and dexmedetomidine, added to a scalp nerve block during brain tumor removal surgery. The goal is to see which provides better pain control and recovery after surgery.
Cairo, GovernorateAges 20–60 - NCT07632833Recruiting
Comfort tote for teens recovering from spine surgery
This study tests whether giving teens a special comfort tote with calming items helps them feel better and recover more smoothly after surgery for scoliosis. It is for patients aged 10 to 21 who are having spinal fusion at a specific hospital.
New York, New YorkAges 12–21 - NCT07553000Recruiting
Splinting for Wrist Fractures Study
This study tests how splinting helps people with suspected broken wrists (fractures of the radius bone at the wrist). You'll be included if you have moderate to severe wrist pain and imaging shows a fracture.
MalmöAges 18 years+
Hear when a new Acute Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for acute pain?
- Yes. Clin2 currently lists 202 recruiting acute pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.