Clinical trials
Advanced Heart Failure clinical trials
Below are recruiting advanced heart failure clinical trials, each written for real people, not researchers. We’re tracking 97 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06671015Recruiting
Comparing breathing support methods after a breathing tube is removed in people with heart failure
This study compares two types of breathing support—a high-flow nasal cannula and noninvasive ventilation—to see which one better prevents the need for re-inserting a breathing tube in people with systolic heart failure who are at high risk for breathing problems after the tube is removed.
New Haven, ConnecticutAges 18 years+ - NCT06661876Recruiting
Heart radiation therapy for heart failure
This trial tests if a low dose of radiation to the heart can help people with advanced heart failure feel better and improve heart function. It is for patients whose heart failure is stable but severe, and who are already on the best medications.
LeuvenAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Phoenix, ArizonaAges 18 years+ - NCT06361524Enrolling by invitation
Gut bacteria study in chronic heart failure
This study looks at the bacteria in your gut (your 'gut microbiome') and how it relates to chronic heart failure. It may help doctors understand why some people with heart failure do better than others and could lead to better treatments in the future.
Stanford, CaliforniaAges 18–75 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Birmingham, AlabamaAges 18–100 - NCT06299176Enrolling by invitationPhase 1
Whole-heart radiation therapy for advanced heart failure
This trial tests if a low dose of radiation to the whole heart can help people with very advanced heart failure. It is for people who have severe symptoms despite maximum medications and are not candidates for a heart pump or transplant.
Montreal, QuebecAges 65 years+ - NCT06228209Recruiting
Palliative care for advanced heart failure or cancer
This study tests whether adding a palliative care specialist to your regular care team can improve your quality of life if you have advanced heart failure or advanced lung or certain gastrointestinal cancers. It is for people who have been in the hospital recently and live in Manhattan.
New York, New YorkAges 18 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT05677100Recruiting
Aortix device for acute heart failure
This trial is testing a small pump placed in the aorta to help the kidneys remove extra fluid when standard IV diuretics aren't working well enough for severe heart failure. It may help you if you're hospitalized and still very congested (swollen, fluid buildup) despite strong water pills.
Phoenix, ArizonaAges 21 years+ - NCT04768322Recruiting
LVAD versus standard heart failure medicines in advanced patients
This trial compares an LVAD device (a pump placed in the chest) plus medicines versus medicines alone for people with advanced, end-stage heart failure. It aims to see which approach works better to help patients live and stay out of the hospital.
BesançonAges 18 years+ - NCT01099982Recruiting
Studying heart tissue and blood changes after advanced heart care
This trial studies how blood and heart tissue change in people with advanced heart failure who are getting an LVAD (a heart pump) or a heart transplant. It may help doctors better understand what’s happening in the heart before and after these treatments.
Murray, UtahAges 13 years+ - NCT07108231Recruiting
Breathing muscle training for hospitalized heart failure patients
This trial tests whether training the muscles you use to breathe can help people recover while in the hospital for heart failure. If you are stable enough, you may be able to join.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT06653725RecruitingPhase 2
Ketone supplement study for hospitalized heart failure patients
This trial tests if a ketone supplement can help people hospitalized for acute heart failure. The supplement is given orally and aims to support the heart and energy levels during recovery.
AalborgAges 18 years+ - NCT06747689Recruiting
Sleep quality and self-care in heart failure
This study looks at how sleep quality affects the ability of people with heart failure to manage their own health. It aims to find if better sleep leads to better self-care.
IzmirAges 18 years+ - NCT06659952Recruiting
HIV+ donor hearts for HIV+ recipients
This trial tests whether hearts from donors who had HIV can be safely transplanted into people with HIV who need a heart transplant. It may offer a new option for those on the waiting list.
Dallas, TexasAges 18 years+ - NCT04405583Recruiting
Follow-up study for a heart device in heart failure patients
This study follows people with chronic heart failure to see how well an implanted device (called the Occlutech AFR) works and whether it is safe over time. It may help doctors better understand who benefits and how to manage treatment safely.
BesançonAges 18 years+ - NCT05390411Enrolling by invitation
Training to improve how advanced heart failure therapies are chosen
This study tests a program that helps care teams make more consistent, fair decisions about advanced heart failure treatments like heart transplants and mechanical heart pumps. It focuses on how professionals are trained and evaluated, not on patients receiving a new medicine.
Indianapolis, IndianaAges 18 years+ - NCT06927440Enrolling by invitation
Registry for children with severe heart failure in China
This study is creating a registry to learn more about children with advanced heart failure. It will help doctors understand who can benefit from treatments like medicine, devices, or transplants.
Shanghai, Shanghai MunicipalityAges Up to 18 years - NCT02537769Recruiting
Surgery to fix a leaky tricuspid valve in LVAD patients
This study looks at whether fixing a mildly leaky tricuspid valve during LVAD surgery improves outcomes for people with advanced heart failure. It’s mainly aimed at patients who are already scheduled to receive an implantable LVAD.
Seattle, WashingtonAges 18 years+ - NCT07775976Enrolling by invitation
Whole-heart checkup with a wearable heart monitor
This study looks at how well a wearable heart monitor and special software can check the health of your whole heart and assess your risk of future heart problems. It may help doctors create more personalized care plans.
Pasadena, CaliforniaAges 18 years+ - NCT07382284Recruiting
Long-term survival after LVAD for end-stage heart failure
This trial looks at how well people with advanced heart failure do over the long term after getting a left-ventricular assist device (LVAD). Researchers will check blood and heart tissue samples to learn more about recovery and outcomes.
Nanjing, JiangsuAges Any age - NCT05271214Recruiting
Testing conservative care for people with failing heart pumps
This trial is studying a non-surgical (conservative) treatment approach for people being considered for a left ventricular assist device (LVAD). It may help some patients who are too sick or unable to tolerate standard heart failure medicines, but it will only match people with specific heart function and health-test results.
Tel AvivAges 18–80 - NCT07632586Recruiting
First-in-Human Heart Pump Implant Study
This trial tests a new tiny heart pump called the Icoms Flowmaker for patients with severe heart failure who cannot have a standard heart pump. The device may help your heart pump blood better and improve your ability to do daily activities.
PragueAges 18–80 - NCT07497308Recruiting
GDF-15 levels and early outcomes after LVAD surgery
This trial looks at a blood marker called GDF-15 in people getting a heart pump (LVAD) to see if it can help predict early recovery or complications. It may help doctors better understand how patients will do after surgery.
Antalya, Please Select:Ages 18 years+
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Common questions
- Are there clinical trials for advanced heart failure?
- Yes. Clin2 currently lists 97 recruiting advanced heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.