Clinical trials
Advanced or Metastatic Breast Cancer clinical trials
Below are recruiting advanced or metastatic breast cancer clinical trials, each written for real people, not researchers. We’re tracking 6,184 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07391215RecruitingPhase 1/Phase 2
Paxalisib for newly diagnosed glioblastoma after standard treatment
This trial tests a drug called paxalisib in people with a newly diagnosed aggressive brain tumor (glioblastoma) who have just finished standard radiation and chemotherapy. The goal is to see if adding paxalisib can help prevent the tumor from coming back by targeting a specific pathway in the cancer cells.
SuttonAges 16 years+ - NCT01036581Recruiting
Brain MRI study to improve brain imaging for drug research
This study uses advanced MRI brain scans to better show how the brain responds to medicines (drug-related effects). You may also do extra safety screening and non-invasive brain stimulation for some parts of the research.
Baltimore, MarylandAges 18–80 - NCT00950118Recruiting
Study for people with congenital diaphragmatic hernia or family history
This study is for people who have a congenital diaphragmatic hernia (a birth-related opening in the diaphragm) or whose family member has had one. The research aims to learn more about the condition using molecular (cell-level) science, which may help improve understanding and future care.
Chicago, IllinoisAges Any age - NCT01099982Recruiting
Studying heart tissue and blood changes after advanced heart care
This trial studies how blood and heart tissue change in people with advanced heart failure who are getting an LVAD (a heart pump) or a heart transplant. It may help doctors better understand what’s happening in the heart before and after these treatments.
Murray, UtahAges 13 years+ - NCT00623389Recruiting
Testing a leg neuroprosthesis for walking and leg control
This trial tests an advanced device that helps control and use your legs and trunk muscles for movement. It may help people with certain types of paralysis or weakness to improve function, while closely monitoring safety and comfort.
Cleveland, OhioAges 21–75 - NCT01853631RecruitingPhase 1
CAR T-cell therapy for CD19-positive B-cell blood cancers
This Phase 1 study tests a personalized form of immune therapy called CAR T cells that are designed to recognize CD19, a marker on certain B-cell cancers. It may help people with difficult-to-treat (recurrent or relapsed) B-cell lymphoma or leukemia (ALL/CLL).
Houston, TexasAges Up to 75 years - NCT02074839RecruitingPhase 1
Oral AG-120 for advanced blood cancers with an IDH1 mutation
This Phase 1 study tests an oral medicine called AG-120 in adults with advanced blood cancers that have a specific IDH1 mutation. It also looks at safety and how the treatment works, with frequent blood, urine, and bone marrow samples.
Birmingham, AlabamaAges 18 years+ - NCT02895165Recruiting
Pregnancy and fertility registry for people with breast cancer
This trial is a registry that collects information about pregnancy and future fertility in people with breast cancer. It may help doctors better understand outcomes and care options for patients in these situations by studying real-world experiences.
Asti, AstiAges 18–45 - NCT02559778RecruitingPhase 2
Precision treatment trial for children with advanced neuroblastoma
This Phase 2 trial studies a targeted treatment approach for children and young adults with advanced neuroblastoma (a childhood cancer). It may help by using lab-tested cancer features to guide therapy after initial treatment and transplant.
Birmingham, AlabamaAges Up to 22 years - NCT02182180Recruiting
SC2i tissue and data collection for people needing urgent care
This study collects small samples of tissue and body fluids and related health data from people who need surgery or treatment in an emergency or critical care setting. The goal is to build a resource researchers can use to better understand illness and improve care.
Atlanta, GeorgiaAges 18 years+ - NCT02511288Recruiting
Blood tests to monitor advanced lung cancer during care
This study checks whether “liquid biopsies” (blood tests) can help monitor advanced non-small-cell lung cancer. It looks at different patient groups based on timing and tumor features, aiming to make cancer tracking easier and less invasive.
AnnecyAges 18 years+ - NCT02838602Recruiting
Carbon beam radiation vs standard radiation for resistant tumors
This study compares carbon beam radiation with standard radiation for tumors that are less likely to respond to usual radiation. It aims to see whether carbon beams can improve control of the cancer while keeping side effects manageable.
AmiensAges 18 years+ - NCT02469662Recruiting
Study of outcomes after Nexel total elbow replacement
This study looks at how well the Nexel total elbow replacement works over time for people who need an elbow replacement due to pain, damage, or instability. It may help the doctors understand which patients benefit most and what results to expect.
Golden, ColoradoAges 18 years+ - NCT02704520Recruiting
MRI scoring test for rectal cancer response to treatment
This study looks at how an MRI “score” (mrTRG) matches how well locally advanced rectal cancer shrinks after pre-surgery chemotherapy and radiation. The goal is to use MRI results to better predict treatment response and guide care.
Aberdeen, AberdeenshireAges 16 years+ - NCT02870244RecruitingPhase 1
Engineered T-cell therapy for advanced melanoma patients
This Phase 1 study tests a lab-made immune cell treatment for advanced melanoma. It aims to see if engineered T-cells can recognize the patient’s tumor and help control the cancer, especially in specific melanoma tissue markers.
Maywood, IllinoisAges 18–89 - NCT03042221Recruiting
Early re-biopsy to find why tumors survive targeted drugs
This study takes a small tumor sample early after starting targeted treatment (or uses blood if a biopsy isn’t possible) to look for clues—called biomarkers—about why some tumor cells survive. The results may help improve how future patients’ treatments are chosen for certain lung cancer gene mutations.
Aurora, ColoradoAges 18–85 - NCT03371407Recruiting
Study brain movement training in people with Parkinson’s
This study looks at how people with Parkinson’s adapt their movements and how their brain sensorimotor system works. It may help researchers improve understanding of Parkinson’s and refine movement-focused therapies.
MarseilleAges 18 years+ - NCT03056794Recruiting
Study of genetic and natural history of PDC deficiency
This study looks at how pyruvate dehydrogenase complex (PDC) deficiency affects people over time and what genes are involved. It mainly helps by building genetic and health data, which may improve future care and understanding of the condition.
Pittsburgh, PennsylvaniaAges Any age - NCT03125642RecruitingPhase 2
Auto stem cell transplant for lymphoma after chemo
This Phase 2 study tests an auto (self) stem cell transplant for people with certain types of non-Hodgkin lymphoma or Hodgkin lymphoma who respond to chemotherapy (they are “chemo-sensitive”). It may help some patients get a deeper or longer remission by resetting the bone marrow after high-dose treatment.
Minneapolis, MinnesotaAges Up to 75 years - NCT05699018Recruiting
Screening people with liver scarring in primary care
This study tests how well primary care doctors can screen for advanced liver scarring in people with fatty liver from non-alcohol causes or from alcohol use. It may help find liver problems earlier so you can get the right follow-up.
AngersAges 40–80 - NCT06246149RecruitingPhase 3
Tebentafusp after treatment for high-risk eye melanoma
This trial tests a new drug called tebentafusp given after standard treatment (surgery or radiation) for high-risk uveal melanoma that hasn't spread. The goal is to see if it helps prevent the cancer from coming back.
Lake Success, New YorkAges 18 years+ - NCT03529019RecruitingEarly Phase 1
Nutrition study for poor blood flow to a limb
This early-phase study looks at how nutrition affects people who have very poor blood flow to a limb (critical limb ischemia). It’s exploring whether nutrition changes health outcomes and safety for this condition.
Boston, MassachusettsAges 18–99 - NCT07059221RecruitingPhase 1/Phase 2
New drug combo for advanced head and neck cancer
This trial tests a new combination of drugs (SHR-A2102 and Adebrelimab) with or without other anti-cancer therapies for head and neck cancer that has come back or spread. It aims to see if these treatments can shrink tumors or slow the disease.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07659821Recruiting
Nutrition and wellness study for moms and babies
This study offers food kits and nutrition guidance to pregnant women to help support their health and their baby's wellness. You may be eligible if you are in early pregnancy (7–12 weeks) and live in the Dallas-Fort Worth or College Station area.
College Station, TexasAges 18–45
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Common questions
- Are there clinical trials for advanced or metastatic breast cancer?
- Yes. Clin2 currently lists 6,184 recruiting advanced or metastatic breast cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic breast cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic breast cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.