Clinical trials
Anterior Cruciate Ligament Injuries clinical trials
Below are recruiting anterior cruciate ligament injuries clinical trials, each written for real people, not researchers. We’re tracking 119 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04295148Recruiting
Compare brace and rehab for ACL reconstruction
This study compares two ways of rehabilitating the knee after ACL rupture repair. It’s meant to see which approach helps people return to their prior sport more safely and effectively.
Stockholm, Stockholm CountyAges 16–40 - NCT04408885Recruiting
Rehab program for a torn ACL ligament
This study looks at a rehabilitation-focused treatment plan after an ACL (an important knee ligament) tear. It may help you by testing the best rehab approach for improving knee function and stability.
Aarhus NAges 18–50 - NCT04572256RecruitingEarly Phase 1
Montelukast after ACL surgery to protect knee cartilage
This early trial tests whether montelukast, a tablet used for allergies, can help protect knee cartilage after ACL surgery. It is specifically for people who have a meniscus injury along with their ACL tear.
Lexington, KentuckyAges 25–50 - NCT04770233Recruiting
Comparing early surgery options for torn ACL
This study looks at the best way to treat a fresh ACL (an important knee ligament) tear by comparing an “early surgery” plan that starts within 12 weeks. It may help guide care and recovery for people who are able to do both the surgery and the follow-up rehabilitation.
Lørenskog, AkershusAges 16–50 - NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35 - NCT05174611RecruitingPhase 2
Vitamin D to strengthen the thigh after ACL surgery
This Phase 2 study tests whether taking vitamin D can improve thigh (quadriceps) muscle strength after ACL reconstruction. It targets people with low vitamin D levels that persist after surgery and weaker thigh strength on the injured side.
Hong KongAges 18–40 - NCT05207943Recruiting
Testing an at-home device for ACL knee injuries
This study tests whether the NXSignal device can help people recover from an anterior cruciate ligament (ACL) injury. You’d use the device while the study team monitors your progress using questionnaires.
Las Palmas de Gran Canaria, Las PalmasAges 16 years+ - NCT05323474Recruiting
Rehab program after ACL surgery to return to competitive sport
This study tests an “optimized” rehabilitation plan after ACL reconstruction to help people safely return to competitive sports. It’s for people who had an ACL surgery and still want to play sports that involve cutting, pivoting, or contact.
Challes-les-EauxAges 18–25 - NCT05391672Recruiting
Study for early surgery after a partial ACL tear
This trial looks at treatment options for people with a partial ACL ligament tear in the knee, including both recent and long-standing injuries. It may help to clarify the best early approach for healing and knee function, especially when there are no other ligament injuries.
AsyutAges 15–50 - NCT05412381RecruitingPhase 3
PRP after ACL injury to help prevent knee arthritis
This study tests whether PRP (platelet-rich plasma) given after an ACL injury and surgery can lower the chance of developing long-term knee arthritis. It may help protect the knee over time by targeting early healing after ACL reconstruction.
New York, New YorkAges 14–50 - NCT05461326Recruiting
Compare two tendon grafts for ACL surgery recovery
This study compares two ways to rebuild the ACL using different tendon grafts (quadriceps tendon vs patellar tendon) taken from your own body. It aims to learn which option leads to better recovery after ACL reconstruction, including strength and function.
Birmingham, AlabamaAges 14–65 - NCT05470790Recruiting
Arabic questionnaire study for ACL knee injury athletes
This study uses Arabic versions of questionnaires to measure knee control and sports cutting/pivoting ability after a one-sided ACL (knee ligament) injury. It may help researchers better evaluate recovery and readiness for sports in Arabic-speaking athletes.
Dammam, Eastern ProvinceAges 18–45 - NCT05501210Recruiting
Knee vibration therapy for ongoing front-of-knee pain after ACL surgery
This trial studies whether a vibrating device on the front of the knee can reduce persistent pain after ACL reconstruction. It may help people whose pain is focused in one knee and isn’t caused by arthritis or other knee problems.
Hong KongAges 18–60 - NCT05701579Recruiting
Testing treatment choices for early ACL cartilage changes before surgery
This trial looks at a treatment strategy for people with specific early changes in the ACL seen on MRI who are planning knee surgery. It may help by testing the best way to address those ACL-related cartilage/mucosa-like changes before or during surgical care.
Bełchatów, Łódź VoivodeshipAges Any age - NCT05747079Recruiting
Early versus delayed surgery after a new ACL tear
This study compares immediate surgery versus waiting a short time for people with a new ACL injury. It aims to see which timing leads to better recovery and knee function.
LeuvenAges 16 years+ - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35 - NCT05949177Recruiting
Mindfulness and graded exercise for fear after ACL surgery
This trial studies whether a combination of mindfulness practice and a step-by-step return-to-activity plan can reduce fear and improve recovery after ACL reconstruction. It may help people who feel worried about re-injury and want a structured way to get back to sports.
Chapel Hill, North CarolinaAges 14–35 - NCT05965310Recruiting
Virtual psychology support for ACL repair recovery
This study tests a virtual (online) psychological program to help people recover after ACL ligament surgery. It focuses on first-time ACL repairs and aims to improve how patients cope during recovery.
Detroit, MichiganAges 13 years+ - NCT05985629RecruitingPhase 4
Numbing shot behind the knee for ACL surgery pain
This study tests whether an extra numbing shot (called IPACK) behind the knee helps reduce pain and the need for strong pain medicine after ACL reconstruction surgery. It's for patients who are having their first ACL surgery and are not using a donor graft.
Maywood, IllinoisAges 16 years+ - NCT06147427Recruiting
ACL reconstruction with or without Lemaire procedure
This study compares two surgical techniques for repairing a torn ACL: standard ACL reconstruction alone versus ACL reconstruction plus a Lemaire procedure (an extra side-stabilizing repair). It aims to see which approach provides better knee stability for active patients over at least 2 years.
LyonAges 18–50 - NCT06193343Recruiting
Steps to prevent osteoarthritis after ACL surgery
This study tests whether increasing your daily steps after ACL reconstruction can help prevent knee osteoarthritis. It involves walking more and tracking your activity over time.
Athens, GeorgiaAges 16–40 - NCT06194682Recruiting
ACL reconstruction follow-up study
This study follows people who have had or will have ACL reconstruction surgery at this hospital. It helps doctors learn more about how patients recover after ACL surgery over the long term.
MilanAges 18–65 - NCT06195423Recruiting
Stopping knee arthritis after an ACL tear
This study tests a home exercise program to prevent knee arthritis after an ACL tear. If you had ACL surgery 9 to 36 months ago and still have some knee symptoms, this program may help protect your knee in the long run.
Vancouver, British ColumbiaAges 16–35
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Common questions
- Are there clinical trials for anterior cruciate ligament injuries?
- Yes. Clin2 currently lists 119 recruiting anterior cruciate ligament injuries studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament injuries trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament injuries trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament
- Anterior Cruciate Ligament (ACL) Reconstruction
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.