Arterial Occlusive Diseases clinical trials

Balloon vs stent for blocked arteries

This trial compares two procedures to open completely blocked coronary arteries: a drug-coated balloon or a drug-eluting stent. It may help patients with a single, medium-length blockage in a large enough artery.

Guiding heart stent decisions to fully treat blocked arteries after a heart attack

This trial compares two ways doctors decide which additional blocked heart arteries to treat with stents soon after a heart attack. It may help patients avoid later heart problems by testing a “complete revascularization” strategy planned after the initial culprit artery was treated.

Angina thresholds study for patients needing stent treatment

This trial is testing a new way to measure blood flow in the heart during exercise to better understand angina. You may be eligible if you have at least two blocked heart arteries and are scheduled for stent placement.

RenZan stent check for leg artery narrowing

This trial follows how well the RenZan stent works and how safe it is for people with blocked or badly narrowed thigh-to-knee leg arteries. It may help by improving blood flow and adding careful monitoring to see how outcomes compare over time.

Shockwave balloon treatment for very hard, blocked iliac arteries

This trial tests a device called Shockwave M5+/L6 intravascular lithotripsy to help deliver stent grafts when the iliac (pelvic) arteries are extremely calcified and hard to access. It may help people who are being evaluated for endovascular (through-the-blood-vessel) treatment but whose anatomy makes standard access difficult.

Find best timing for stent procedure in NSTEMI with multiple vessel disease

This trial compares when to do a stent procedure (PCI) in people with NSTEMI who have disease in more than one coronary artery (non-IRA). It may help doctors choose the safest and most effective timing for treatment to improve outcomes.

Dissolving stent with drug for blocked heart arteries

This trial tests a stent that slowly dissolves after opening a blocked heart artery, releasing a drug to prevent reclogging. It may help people with narrowing in one or two spots that are not too hard or twisted.

New imaging & catheter system for blocked heart arteries

This trial tests a new imaging and catheter system to treat chronic total blockages in heart arteries. If you still have chest pain or other symptoms despite medical therapy, this study may help open the blockage and improve blood flow.

AGENT balloon for new heart artery blockages

This trial tests a drug-coated balloon (AGENT DCB) versus standard angioplasty/stenting for new blockages in heart arteries. It aims to see if the coated balloon works better and is safe for people who haven't had prior stents in that spot.

Test opening blocked heart arteries using two different procedures

This trial studies whether two ways of threading a device to open a long-term blocked coronary artery are both safe and effective. You may qualify if you have a chronic total blockage and heart-related symptoms, and you can follow the study follow-up plan.

Low-intensity shockwave versus wave therapy for erectile and pelvic pain

This trial compares two types of low-intensity wave therapy to see which works better for erectile dysfunction and/or chronic pelvic pain. Participants may benefit if these therapies improve erection quality and reduce pelvic pain.

Drug-coated balloon for severe leg artery blockage in lower legs

This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.

Brain artery calcium and clot removal outcomes

This study looks at whether calcium buildup in brain arteries affects how well clot removal (mechanical thrombectomy) works for stroke patients. You may be able to join if you have a large artery blockage, a CT scan was done, and you are having the clot removal procedure.

NEXUS Registry for coronary artery disease or Afib patients

This is a research registry that collects health information about people with coronary artery disease or Afib. It may help doctors and researchers better understand these heart conditions and improve future care.

Identification for High Risk of Coronary Heart Disease Based on Quantitative Analysis of Fundus Vessels and Metabolic Molecules

Spleen shrinking procedure for severe hypersplenism

This trial tests a procedure that uses heat or cold to shrink part of the spleen and block some of its blood supply, which may improve low blood counts caused by cirrhosis-related hypersplenism. It is for patients whose low white blood cells or platelets have not improved with medicine.

Testing a new heart bypass graft in people needing multi-vessel CABG

This study tests a new way to connect a bypass graft during heart bypass surgery for people with blocked heart arteries. The goal is to see if the new graft can be safely placed and works well enough to improve outcomes compared with the standard approach.

Compare two stent types for blocked thigh artery disease

This trial compares a special drug-coated balloon/stent strategy versus a standard stent approach for people with blocked thigh artery segments. It aims to improve how long the artery stays open and reduces repeat procedures.

New drug balloon for re-narrowed stents

This trial tests a new drug-coated balloon (Genoss SCB) versus an existing one (SeQuent Please NEO) for people whose heart stents have re-narrowed. It aims to see which balloon better keeps the artery open.

Thrombectomy for large stroke in back of the brain

This trial is testing whether a clot removal procedure, called endovascular thrombectomy, can help people who have a large stroke in the back part of the brain. To be eligible, the stroke must be from a blocked artery in the base of the skull, and the stroke must be severe and recent.

Sirolimus-coated balloon for heart artery branch blockages

This trial tests a new balloon coated with sirolimus (a drug that helps prevent re-blockage) for treating blocked arteries at branch points (bifurcations) in the heart. If you have a blocked artery at a branch point, this study may offer a way to treat the side branch without placing a stent there.

Shockwave balloon for hard heart blockages trial

This trial tests a new balloon catheter that uses sound waves to break up hard calcium blockages in heart arteries. It may be an option for people with stable chest pain or who have recovered from a recent heart attack, and who have a single, tough blockage.

Drug-coated stent trial for narrowed heart arteries

This trial studies a drug-coated balloon (plus standard heart medicines) to treat a specific type of blockage in the heart arteries in people who need an intervention. It may help keep the artery open and prevent the narrowing from coming back, depending on how well you match the detailed heart and medication requirements.

Aspirin plus one blood thinner versus aspirin plus clopidogrel

This trial compares two common “blood thinner” combinations to prevent problems after a PCI procedure for complex blocked heart arteries. It may help your care team find which combination works better for people with higher-risk artery patterns.