Clinical trials
Brain Metastases clinical trials
Below are recruiting brain metastases clinical trials, each written for real people, not researchers. We’re tracking 154 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05064280RecruitingPhase 2
Pembrolizumab plus lenvatinib for brain metastases from solid tumors
This Phase 2 trial studies whether combining pembrolizumab with lenvatinib can shrink or control brain metastases in people with triple-negative breast cancer, lung cancer, or other solid tumors. It focuses on patients who have measurable brain lesions that can be followed on MRI.
Houston, TexasAges 18 years+ - NCT05013892RecruitingPhase 2
Whole-brain radiation with a targeted drug plan for brain mets
This Phase 2 study tests a treatment plan that combines whole-brain radiation therapy with an additional approach to help people with brain metastases. It aims to improve outcomes while also tracking brain function and memory over time.
Boston, MassachusettsAges 18 years+ - NCT05048212RecruitingPhase 2
Nivolumab, ipilimumab, and cabozantinib for kidney cancer brain spread
This Phase 2 study tests how well nivolumab plus ipilimumab, along with cabozantinib, treats untreated or worsening kidney cancer that has spread to the brain. It may help shrink brain tumors and slow the disease when standard local brain treatments aren’t the right option.
Houston, TexasAges 18 years+ - NCT04899908RecruitingPhase 2
Brain radiation with or without gadolinium nanoparticles for brain metastases
This trial tests whether adding tiny gadolinium-containing nanoparticles to standard brain radiation can better control brain metastases from certain cancers. It is for people with tumors that have grown after immunotherapy, are from certain cancers (like melanoma, GI, or HER2+ breast), are cystic, are large, or have come back after prior radiation.
Boston, MassachusettsAges 18 years+ - NCT04923542RecruitingPhase 1/Phase 2
Targeted drug plus focused brain radiation for breast cancer
This study tests whether abemaciclib (a targeted pill) given with focused radiation to brain tumors can control hormone receptor–positive, HER2-negative breast cancer in the brain. It’s designed to see if the combination helps shrink or slow the growth of brain metastases while keeping side effects manageable.
Tampa, FloridaAges 18 years+ - NCT04689048RecruitingPhase 1
Testing a brain scan tracer for large, staged brain metastases
This Phase 1 study tests an injected radioactive tracer (18F-fluciclovine) to improve how doctors image and assess large brain metastases. It may help guide treatment when you’re receiving staged stereotactic radiosurgery (focused radiation in steps).
Miami, FloridaAges 18 years+ - NCT03550391RecruitingPhase 3
Surgery-like brain radiation vs avoiding the memory center
This trial compares two ways of giving radiation to the brain for people with 5 or more brain metastases: focused stereotactic radiosurgery, or a whole-brain approach that tries to spare the memory area (with memantine). It aims to see which method better protects thinking and memory while still treating the tumors.
Tucson, ArizonaAges 18 years+ - NCT02747303RecruitingPhase 2
Focused radiation for 1 to 5 brain metastases without surgery
This Phase 2 study tests a precise, no-head-frame radiation technique to treat brain metastases. It may help by aiming radiation tightly at the tumors while limiting exposure to nearby healthy brain.
Chicago, IllinoisAges 18 years+ - NCT02896335RecruitingPhase 2
Palbociclib and pembrolizumab for brain metastases
This study tests two drugs, palbociclib and pembrolizumab, for people whose solid tumors (like breast cancer or melanoma) have spread to the brain. The goal is to see if this combination can shrink or slow the growth of brain tumors that are progressing despite prior treatment.
Boston, MassachusettsAges 18 years+ - NCT02390518RecruitingPhase 1
Tested different radiation doses for brain metastases
This Phase 1 study tests how to safely give focused radiation (SRS) at different doses to people with brain metastases. It aims to find a dose level that works well while limiting side effects.
Salt Lake City, UtahAges 18 years+ - NCT07481786RecruitingPhase 3
Bevacizumab with focused radiation vs standard brain radiation for lung cancer with brain spread
This trial tests combining a drug called bevacizumab with a focused radiation treatment for people with lung cancer that has spread to the brain. It compares this to the standard radiation approach, and aims to see which better preserves memory and controls tumors.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT06712927RecruitingPhase 2
Three-drug immunotherapy for melanoma brain metastases
This trial tests a combination of three immunotherapy drugs (relatlimab, nivolumab, and ipilimumab) for people with melanoma that has spread to the brain. It aims to see if this treatment can shrink brain tumors and improve outcomes.
Palo Alto, CaliforniaAges 18 years+ - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+ - NCT05700721RecruitingPhase 2
Niraparib and dostarlimab for cancer with growing brain spots
This trial studies whether the medicines niraparib and dostarlimab can slow advanced cancers that have active, growing brain metastases. It is meant for people whose brain tumors can be measured on MRI and who have had at least one previous treatment.
Houston, TexasAges 18 years+ - NCT05124912Recruiting
Laser treatment for recurrent brain metastases after prior SRS
This study tests whether repeating treatment with a laser (along with a small biopsy) can control brain metastases that have come back after earlier radiation called SRS. It may help people whose cancer is stable enough for surgery and who have a specific, reachable brain spot to target.
Los Angeles, CaliforniaAges 18 years+ - NCT07053033RecruitingPhase 2
Laser surgery or surgery plus second radiation for recurrent brain tumors
This trial is testing whether a second, precise dose of radiation to the brain, after a tumor has been removed or treated with a laser, can help people with recurrent brain metastases. It's for patients whose brain tumors have come back after prior radiation therapy.
Houston, TexasAges 18 years+ - NCT06253871RecruitingPhase 1
Study of IAM1363 for HER2 Cancers
This trial tests a new oral drug called IAM1363 for people with HER2-altered cancers that have stopped responding to previous treatments. The goal is to see if the drug is safe and how well it works against these cancers.
La Jolla, CaliforniaAges 18 years+ - NCT05872347RecruitingPhase 2
Brain metastasis breast cancer trial with hormone therapy plus SPH4336
This trial tests whether SPH4336, added to standard hormone (endocrine) therapy, can improve outcomes for people with breast cancer that has spread to the brain. It also looks closely at safety and side effects.
Hefei, AnhuiAges 18–75 - NCT07058428RecruitingPhase 3
FSRT with Avastin for multiple brain tumors from lung cancer
This trial tests giving focused radiation (FSRT) along with Avastin (bevacizumab) to people with multiple brain metastases from lung adenocarcinoma. It aims to see if combining these treatments is safe and effective for tumors that are too large or numerous for standard one-time radiation.
Guangzhou, GuangdongAges 18 years+ - NCT05692635RecruitingPhase 2
Brain MRI checks to prevent lung cancer brain symptoms
This trial tests whether doing scheduled brain MRI scans can lower the chance that lung cancer later causes symptomatic brain metastases (tumors that cause symptoms in the brain). If you’re eligible, you’ll get brain MRI surveillance at a specific time after starting radiation.
Winston-Salem, North CarolinaAges 18 years+ - NCT04115254Recruiting
MRI-guided focused radiation for certain tumors
This study tests a type of high-precision radiation guided by MRI pictures to treat certain cancers. It may help doctors deliver radiation more accurately while avoiding nearby healthy tissue, but you must be able to safely complete an MRI scan and meet tumor-size and health requirements.
Boston, MassachusettsAges 18 years+ - NCT06243003RecruitingPhase 1/Phase 2
Brain radiation for SCLC with brain metastases
This trial tests a new radiation approach for people with small cell lung cancer that has spread to the brain. It combines whole-brain radiation that avoids the memory centers, followed by focused radiation to the tumors, while you also receive standard chemotherapy and immunotherapy.
ShanghaiAges 18 years+ - NCT06401824RecruitingPhase 2
Combination drug therapy for lung cancer with brain spread
This trial tests a combination of two drugs, sacituzumab govitecan and bevacizumab, for people with a specific type of lung cancer (non-squamous) that has spread to the brain. It aims to see if this treatment can shrink brain tumors and improve outcomes.
AmsterdamAges 18 years+ - NCT06136884RecruitingPhase 1
Study of AO-252 for advanced solid tumors with or without brain metastases
This trial tests an experimental oral pill (AO-252) that targets a protein called TACC3 in advanced solid tumors, including those that have spread to the brain. It is for people whose cancer has a specific genetic change (TP53 mutation) or who have prostate cancer, and who have already tried other treatments.
Detroit, MichiganAges 18 years+
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Common questions
- Are there clinical trials for brain metastases?
- Yes. Clin2 currently lists 154 recruiting brain metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.