Clinical trials
Cancer Surgery clinical trials
Below are recruiting cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 849 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04699292Recruiting
Registry study for local treatment in soft tissue sarcoma
This registry collects coded information about adults with a specific soft tissue sarcoma (MLS) to better understand how local treatments help. If you qualify, you don’t necessarily receive a new drug in this study—your data is used to improve future care.
AmsterdamAges 18 years+ - NCT04224389Recruiting
Radiation plus throat surgery for early tonsil or tongue-base cancer
This study compares ways of treating early squamous cell cancer in the tonsil or the tongue base, using either radiation therapy, transoral (through-the-mouth) surgery, or both. It aims to see which approach works best while keeping cancer under control.
Villejuif, Val De MarneAges 18 years+ - NCT07039162RecruitingPhase 2
Tislelizumab with chemo and radiation before surgery for advanced esophageal cancer
This trial tests a combination of an immunotherapy drug (tislelizumab) with chemotherapy and radiation, followed by surgery, for people with advanced esophageal cancer that cannot be removed right away. It aims to see if this approach can help shrink the tumor enough to allow surgery.
Kaohsiung CityAges 20 years+ - NCT05808920Recruiting
Salvage surgery study for recurrent head and neck skin-cell cancer
This study looks at how well people do after “salvage” surgery (planned surgery after prior treatment) for recurrent or residual squamous cell cancer in the head and neck. It may help doctors understand which patients benefit most, including how this surgery affects survival and day-to-day function.
DerbyAges 18 years+ - NCT05485766RecruitingPhase 2
Pembrolizumab with cancer medicines for BRCA-mutated triple negative breast cancer
This Phase 2 trial studies a treatment plan given before surgery (neoadjuvant) and after surgery (adjuvant) for people with BRCA1/2-mutated triple negative breast cancer that has not spread. It aims to improve how well the cancer responds and how long people stay cancer-free.
Gifu, GifuAges 18 years+ - NCT07113275RecruitingPhase 3
Short versus long radiation schedule for advanced rectal cancer
This study compares two different schedules of radiation (a short course versus a longer course) followed by standard chemotherapy and immunotherapy for advanced rectal cancer. It aims to see which approach works best to shrink the tumor before surgery.
Wuhan, HubeiAges 18–75 - NCT07724028Enrolling by invitation
Nerve stimulation during robotic prostate surgery
This study tests whether stimulating specific nerves during robotic prostate surgery helps preserve erectile function. If you are scheduled for prostate surgery and have normal erections now, this research may help improve your recovery of erections afterward.
LjubljanaAges 18 years+ - NCT07089199RecruitingPhase 2
Treatment before surgery for stage 2–3 lung cancer
This study tests whether giving a combination of three medicines before surgery can help shrink tumors in people with stage 2 or 3 non-small cell lung cancer, potentially making surgery and recovery more effective. The medicines include an immunotherapy drug (tislelizumab), a targeted therapy (anlotinib), and a chemotherapy drug (nab-paclitaxel).
Jinan, ShandongAges 18–75 - NCT06974500Recruiting
Bowel stimulation before ileostomy closure surgery
This study tests a stimulation program for the bowel loop before surgery to close an ileostomy. It may help your bowel get ready and improve recovery after the procedure.
MadridAges 18 years+ - NCT07071727Recruiting
Short course of radiation before surgery for soft tissue sarcoma
This trial tests whether a shorter course of radiation before surgery is effective for soft tissue sarcomas in certain locations. It aims to make treatment more convenient while maintaining good results.
AmsterdamAges 18 years+ - NCT06980038RecruitingPhase 2
Testing two immunotherapy drugs before surgery for advanced head and neck cancer
This trial tests whether adding a second immunotherapy drug (CDX-1140) to the standard immunotherapy cemiplimab before surgery is better than cemiplimab alone for people with stage III-IV head and neck cancer that can be removed with surgery.
Irvine, CaliforniaAges 18 years+ - NCT06906887RecruitingPhase 2
Pulsed low-dose radiation vs standard chemoradiation for esophageal cancer
This trial compares a new way of giving radiation (in short, pulsed low-dose bursts) to the standard method, both combined with chemotherapy, for people with esophageal cancer. It aims to see if the pulsed approach is safer and equally effective.
Milwaukee, WisconsinAges 18 years+ - NCT06349668RecruitingPhase 3
Comparing spinal morphine and IV lidocaine for robotic kidney surgery
This trial compares two ways to manage pain during robotic-assisted kidney or ureter surgery: a spinal injection of morphine or an intravenous infusion of lidocaine. The goal is to see which method provides better pain relief and recovery.
KalmarAges 18 years+ - NCT07837739Recruiting
EGFR-targeted pill after surgery for early lung cancer
This trial tests whether taking an EGFR-targeted pill after lung cancer surgery can lower the chance of the cancer coming back. It is for people with early-stage non-small cell lung cancer that has a specific EGFR mutation.
Wuhan, HubeiAges 18–75 - NCT07463963Recruiting
Urine culture before bladder tumor surgery to prevent fever from infection
This trial checks if doing a urine culture before bladder tumor surgery can help prevent fever from urinary tract infections after surgery. It compares two ways of managing pre-surgery urine testing to see which is more effective in reducing post-surgery infection risks.
AngersAges 18 years+ - NCT03406247RecruitingPhase 2
Immunotherapy after salvage surgery for head and neck cancer
This Phase 2 trial tests an immunotherapy given after salvage surgery for certain head and neck squamous cell cancers that came back (or a new second cancer) in an area that was already treated with radiation. It aims to lower the chance the cancer returns after surgery, especially in higher-risk situations.
Villejuif, Val De MarneAges 18 years+ - NCT06998342RecruitingPhase 2
Mohs surgery plus short radiation for head and neck skin cancer
This trial studies a combination of Mohs surgery and a short course of radiation therapy for people with squamous cell skin cancer of the head and neck. The goal is to see if this approach is effective with fewer side effects.
Burlington, VermontAges 18 years+ - NCT06848465RecruitingPhase 1
Radiation plus chemo-immunotherapy for colon cancer with liver spread
This trial tests a combination of low-dose radiation, chemotherapy, and immunotherapy for people with colorectal cancer that has spread only to the liver. The goal is to see if this approach can shrink tumors and improve outcomes.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT07516366RecruitingPhase 2
Immunotherapy before surgery for clear cell kidney cancer
This trial tests whether giving two immunotherapy drugs before surgery can safely shrink kidney cancer tumors and help your body fight the cancer. You would receive the drugs before your scheduled surgery, and then your cancer would be removed as planned.
Irvine, CaliforniaAges 18 years+ - NCT07841236RecruitingPhase 2
Blood test-guided immunotherapy for MSI-high colon cancer
This trial tests whether using a simple blood test (ctDNA) can help guide treatment with immunotherapy drugs (PD-1 inhibitors) for people with a specific type of colon cancer (MSI-high/dMMR). The goal is to see if this approach can improve outcomes and reduce side effects compared to standard care.
ShanghaiAges 18–75 - NCT06580574RecruitingPhase 2
Immunotherapy to save the stomach or colon from surgery
This trial tests whether using immune checkpoint inhibitors alone (like checkpoint blockade drugs) can help people with certain gastric or colon cancers avoid surgery. It's for patients whose tumors have a specific genetic feature called dMMR/MSI-H and haven't spread to other parts of the body.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07419932Recruiting
Pre-surgery treatment for advanced thyroid cancer
This study tests whether giving treatment before surgery (neoadjuvant therapy) helps people with locally advanced thyroid cancer. It aims to shrink the tumor so surgery can be more successful.
Fuzhou, FujianAges 14–80 - NCT07165847RecruitingPhase 2
Combination therapy before surgery for gastric cancer
This trial tests a combination of radiation, chemotherapy, and two immunotherapy drugs before surgery for people with resectable gastric or gastroesophageal junction cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
Chongqing, Other (Non U.s.)Ages 18 years+ - NCT03861299Recruiting
Awake brain surgery versus sleep surgery for glioblastoma
This study compares two ways of doing brain surgery for glioblastoma: doing parts of the operation while you are awake, versus doing it fully under general anesthesia (sleep). It aims to see which approach is safer and better for protecting brain functions like speech and movement while removing the tumor.
GhentAges 18–90
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Common questions
- Are there clinical trials for cancer surgery?
- Yes. Clin2 currently lists 849 recruiting cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.