Clinical trials
Cardiac clinical trials
Below are recruiting cardiac clinical trials, each written for real people, not researchers. We’re tracking 1,296 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05450328RecruitingPhase 2
Breathing medicine to help heart-lung machine separation after surgery
This Phase 2 trial tests whether inhaled medicines (milrinone and epoprostenol) can make it easier to separate from the heart-lung machine during cardiac surgery. It may help reduce the risk of a difficult transition off the machine for the right patients.
Montreal, QuebecAges 18 years+ - NCT05423665Recruiting
Ultrasound check to spot early growth problems in twin pregnancies
This study uses a special ultrasound method (speckle tracking echocardiography) to look for early signs that a twin pregnancy may have impaired fetal growth. It may help clinicians detect problems earlier and better understand how twin babies’ hearts and growth are affected.
GhentAges 18–45 - NCT05398276Recruiting
Coaching for exercise anxiety through body-sensation exposure
This study tests whether a behavioral training approach that helps you become more comfortable with body sensations during exercise can reduce exercise anxiety. It may help people who are less active because they feel anxious when exercising.
East Brunswick, New JerseyAges 40 years+ - NCT05371470Enrolling by invitation
Smartphone voice analysis to track depression and anxiety in rehab
This study tests whether a smartphone app that listens to your voice can detect changes in depression and anxiety while you’re in cardiac rehabilitation. If it works, it may help people get timely support during recovery.
Rochester, MinnesotaAges 18 years+ - NCT05412862Recruiting
Improving mood after a recent heart event
This study looks at whether increasing positive emotions after an acute heart problem (like a heart attack or unstable angina) can help patients feel and function better. You may be eligible if you had a recent heart event and are not currently getting enough physical activity.
Boston, MassachusettsAges 18–95 - NCT05366361Recruiting
Study of persistent atrial fibrillation during heart procedures
This study looks at what happens in the heart in people with persistent atrial fibrillation when they undergo an ablation or Maze surgery. It may help doctors better understand the condition and improve future care for people needing these procedures.
Stanford, CaliforniaAges 22–80 - NCT05302271RecruitingPhase 1
Gene therapy for the heart problems in Friedreich's ataxia
This trial tests a one-time gene therapy that delivers a corrected copy of the frataxin gene directly to the heart. It aims to improve or stabilize heart function in people with Friedreich's ataxia who have early or advanced heart involvement.
New York, New YorkAges 12–50 - NCT05265520Recruiting
Pacing strategy study for certain heart failure patients
This trial tests a pacing approach designed to improve how the heart beats in some people with heart failure and a specific heart rhythm pattern on ECG. If you already need a device (CRT-D) based on your results, the study may help see whether this pacing correction improves outcomes.
Phoenix, ArizonaAges 18 years+ - NCT05263804Recruiting
Study uses MRI and blood clues after ischemic stroke
This study looks for biological and imaging markers that may predict heart/vascular outcomes after an ischemic stroke. You may join if you are eligible for standard stroke treatment and can complete planned follow-up and MRI scans.
BronAges 18 years+ - NCT05300451Enrolling by invitationPhase 2
Daratumumab to help lower rejection risk before heart transplant
This Phase 2 trial tests daratumumab to reduce your body’s immune reaction (HLA antibodies) before a heart or heart-and-kidney transplant. It may help lower the risk of immediate, severe rejection in people who already have high antibody levels.
Rochester, MinnesotaAges 18–80 - NCT05208567Recruiting
Testing heart ultrasound in older adults with weak heart pumping
This trial uses a heart ultrasound test to find people who may have weak heart pumping function, especially in a multi-ethnic community. It may help improve how doctors detect this condition earlier using ultrasound images.
LondonAges 65 years+ - NCT05214365Recruiting
Pacing study to help people with heart block avoid stronger harm
This study looks at a heart pacing approach to prevent damage to the heart muscle that can sometimes happen after a pacemaker is placed for atrioventricular (heart rhythm) block. It may help some people avoid worsening heart function over time.
BarcelonaAges 18–100 - NCT05239364Recruiting
Ablation for an abnormal heart rhythm after prior AF surgery
This trial tests a procedure to “ablate” (treat) a specific fast heart rhythm in the upper chambers of the heart that happens after previous atrial fibrillation (AF) ablation or heart surgery. It may help by stopping the rhythm and reducing symptoms, while doctors check how well the targeted mapping and ablation work.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT05144503Recruiting
Test of a new catheter procedure for irregular heart rhythm
This study checks how safe and effective a special catheter procedure (SpherePVI) is for treating paroxysmal (comes and goes) or persistent atrial fibrillation. You may be considered if your atrial fibrillation keeps returning and you’ve already tried at least one medication but it didn’t work or you couldn’t tolerate it.
VilniusAges 18–75 - NCT05184790Recruiting
Using imaging during radiation therapy to improve AI planning
This study tests how well an artificial intelligence system can use special X-ray images taken during certain radiation treatments to improve care. You may qualify if you’re having radiation for specific conditions and your treatment center uses the required imaging steps.
Saint Leonards, New South WalesAges 18 years+ - NCT05146180Recruiting
Scan to help diagnose infection on a replaced heart valve
This study tests a special type of PET/CT scan to better detect infections on a prosthetic (replaced) heart valve. It may help doctors confirm whether infection is present, based on imaging results.
RouenAges 18 years+ - NCT05115214Recruiting
Device test for treating irregular heartbeat with AF ablation
This trial studies a heart procedure using the Affera SpherePVI system to treat paroxysmal (comes and goes) or persistent atrial fibrillation. It’s for people who still have symptoms despite at least one anti-arrhythmia medicine, and who are good candidates for catheter ablation.
PragueAges 18–75 - NCT05098665Recruiting
Home monitoring to help prevent hospital stays for ATTR heart disease
This trial tests whether using home weight/health tracking can help people with ATTR cardiomyopathy avoid going to the hospital. It may help by catching fluid build-up or worsening earlier so treatment can be adjusted sooner.
London, LondonAges 18 years+ - NCT05100940Recruiting
Study after a heart procedure complication
This trial looks at what happens after complications during or after a heart procedure called coronary angiography or PCI. It may help improve care and outcomes for people who experience a problem during treatment.
Minneapolis, MinnesotaAges 18 years+ - NCT04336644Recruiting
Checks heart rhythm continuously or intermittently during treatment
This study compares two ways of monitoring your heart rhythm while you start certain cancer treatments. It may help doctors detect heart rhythm changes earlier and decide which monitoring approach is better.
St Louis, MissouriAges 18 years+ - NCT05066347Recruiting
Remote heart monitoring after fainting discharge from the ER
This trial studies whether remote heart monitoring after an ER visit for fainting (syncope) can help identify dangerous heart problems. You may be enrolled only if your fainting episode seems medium- to high-risk and you’re being sent home from the ER.
Ottawa, OntarioAges 18 years+ - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Birmingham, AlabamaAges 18 years+ - NCT05014802Recruiting
MRI scans before heart surgery to predict post-surgery atrial fibrillation
This study uses an MRI scan before heart surgery to look for heart scarring that may predict who will develop atrial fibrillation afterward. Knowing the risk ahead of time could help doctors monitor you more closely and plan prevention.
Covington, LouisianaAges 40–120 - NCT05051254Recruiting
Breathing muscle testing in children with breathing muscle weakness
This study looks at how hard it is for children to breathe and how their breathing muscles work, using specific breathing-related tests. It may help doctors better understand breathing problems and choose care more effectively.
ParisAges birth–17 years
Hear when a new Cardiac trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for cardiac?
- Yes. Clin2 currently lists 1,296 recruiting cardiac studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cardiac trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cardiac trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.