Clinical trials · California
Cardiovascular Diseases clinical trials in California
We’re tracking 51 recruiting cardiovascular diseases studies with a site in California — including Early Phase 1, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT05642858Recruiting
Learn heart health tips for people living with HIV
This study tests a text-message education program to help people living with HIV manage cardiovascular (heart and blood vessel) health. It may be helpful if you are 40 or older and can use a smartphone to receive messages.
San Francisco, CaliforniaAges 40 years+ - NCT07780500Recruiting
Using electronic health records to study people with high blood pressure
This study is not testing a new medicine. Instead, it is using electronic health records to better understand people with high blood pressure, with a focus on those recently diagnosed. If you join, you may help researchers learn more about how to improve care for others with high blood pressure.
Oakland, CaliforniaAges 18 years+ - NCT02582021Recruiting
Study of treatments and imaging in women with angina or HFpEF
This trial studies how heart disease affects the heart using heart imaging, and looks at people with chest pain/angina or heart failure with preserved pumping strength (HFpEF). It may help doctors better understand what’s driving symptoms and how best to evaluate these conditions.
Los Angeles, CaliforniaAges 18 years+ - NCT06476795Recruiting
Grape pomace from chardonnay for heart and gut health in postmenopausal women
This study tests if consuming a powder made from chardonnay grape pomace (the leftover skins and seeds from winemaking) can improve gut and heart health in postmenopausal women. You may be a good fit if you are between 45-70, have gone through menopause, and have higher levels of blood fats called triglycerides.
Davis, CaliforniaAges 45–70 - NCT07303777RecruitingPhase 2
Study of ABP-745 for people with atherosclerosis
This trial tests a new medication called ABP-745 to see if it helps people with atherosclerosis (hardening of the arteries). It is for people who are already taking a cholesterol-lowering medicine and who have had a special heart artery X-ray (coronary angiography).
San Diego, CaliforniaAges 18–75 - NCT07517263RecruitingPhase 3
Long-term Safety Study of Pelacarsen Treatment
This study follows patients who completed an earlier pelacarsen trial to check if the treatment remains safe and well-tolerated over time. Pelacarsen is an experimental medicine being tested for heart and cholesterol health.
Beverly Hills, CaliforniaAges 18–100 - NCT07613294RecruitingPhase 3
Testing lepodisiran to reduce heart plaque buildup
This study tests whether a new medicine called lepodisiran can shrink plaque in heart arteries for adults with high Lp(a) (a type of cholesterol linked to heart disease) who have had a heart event or are at serious risk. The trial uses CT scans to monitor changes in your arteries.
La Jolla, CaliforniaAges 45–80 - NCT05423158Recruiting
Virtual coaching to help veterans attend cardiac rehab
This study tests if virtual coaching can help more veterans attend cardiac rehabilitation at home. It is for veterans with heart conditions who have been referred to home-based cardiac rehab.
San Francisco, CaliforniaAges 21 years+ - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Long Beach, CaliforniaAges 75 years+ - NCT05423860Recruiting
HALO prostate study for men with early prostate cancer
This trial studies HALO, a new “human analytics” approach, in men with early-stage prostate cancer. It may help doctors better assess or guide care using MRI and biopsy findings, before or around initial treatment.
Indian Wells, CaliforniaAges 45–90 - NCT05473871Recruiting
Help churches deliver low-exercise physical activity programs
This trial tests a program to help churches support people who currently get little exercise to become more active. You may be invited to join activities through your church over the next 18 months.
San Diego, CaliforniaAges 18–65 - NCT05488431RecruitingPhase 2
Bempedoic acid to lower cholesterol and inflammation in HIV
This Phase 2 trial studies whether bempedoic acid can lower cholesterol and inflammation in people with HIV who are already on effective HIV medications. It may help reduce signs of artery inflammation that can contribute to heart and stroke risk.
San Francisco, CaliforniaAges 40 years+ - NCT05545865Recruiting
Test how grape-based drinks affect blood flow response
This study tests whether a grape product (“Chardonnay Marc”) can change how your blood vessels respond to stress, measured with a finger sensor. It may help researchers understand how diet influences circulation in people with a low baseline blood-flow response.
Davis, CaliforniaAges 30–50 - NCT06014515RecruitingEarly Phase 1
Single injection PET scan to study body metabolism
This study uses a single injection and a special type of PET scan to look at how your body's tissues use fuel (metabolism). It helps researchers learn more about normal and disease-related changes in the heart, liver, and other organs.
Sacramento, CaliforniaAges 18 years+ - NCT06648278Recruiting
Support and technology study for breast cancer patients
This trial tests a program called PONTS 2.0 that uses phone texts and online tools to support breast cancer patients through their treatment. It aims to make it easier for patients to get the help they need.
San Francisco, CaliforniaAges 18 years+ - NCT06813911RecruitingPhase 3
Testing pelacarsen for high Lp(a) in heart disease patients
This trial tests a new medicine called pelacarsen for people with very high Lp(a) (a type of cholesterol) and existing heart or blood vessel disease. It aims to see if adding pelacarsen to your current cholesterol treatment can lower your Lp(a) levels further.
Beverly Hills, CaliforniaAges 18–80 - NCT06875973RecruitingPhase 3
Pelacarsen long-term extension study
This trial is for people who have already finished taking pelacarsen in a previous study. It offers continued access to the drug and checks long-term safety.
Beverly Hills, CaliforniaAges 18–100 - NCT07000357RecruitingPhase 3
Study of AZD0780 to reduce heart attack and stroke risk
This trial tests a new medication, AZD0780, to see if it helps prevent major cardiovascular events like heart attacks or strokes in people who already have heart or blood vessel disease, or are at high risk for a first event. It might be a good fit if your cholesterol isn't well-controlled despite current treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT05472597Enrolling by invitation
Follow-up study about heart health after pregnancy
This study is continuing follow-up interviews and surveys to learn about heart health after pregnancy. If you already took part before, it may help researchers understand how postpartum health changes over time.
Orange, CaliforniaAges 18 years+ - NCT07114718Recruiting
Stent for babies with heart defect needing extra blood flow
This trial tests a special stent for babies with a heart defect that needs a temporary blood vessel to stay open. The stent is placed to help blood flow to the lungs until the baby can have a more permanent surgery.
Los Angeles, CaliforniaAges 1 minute–6 months - NCT05390892RecruitingPhase 4
Preventing kidney and heart damage in type 2 diabetes
This study tests whether diabetes medicines can help prevent worsening heart and kidney problems in people with type 2 diabetes. You’ll be assigned by chance to one of these medicine types, and your other care will be adjusted for safety.
Los Angeles, CaliforniaAges 40–80 - NCT06114615Recruiting
Remote monitoring after heart treatment to prevent future events
This trial tests whether digital tools can help monitor patients after a stent procedure to lower the chance of another heart problem. It aims to make follow-up care easier and more effective.
Sacramento, CaliforniaAges Any age - NCT05931276RecruitingPhase 3
Beta blocker choice may improve heart outcomes on dialysis
This phase 3 study tests whether a specific beta blocker selection on hemodialysis can improve cardiovascular outcomes. It focuses on certain beta blockers commonly used through the VA pharmacy and compares them in a randomized way.
Long Beach, CaliforniaAges 18 years+ - NCT01517425Enrolling by invitation
Using blood stem cells to study heart disease traits
This study uses your blood to create special lab cells (induced pluripotent stem cells) to better understand heart-related differences between people with coronary artery disease and generally healthy older adults. It may help researchers learn what biological traits are linked to heart risk and how those traits work.
La Jolla, CaliforniaAges 18 years+
Cardiovascular Diseases trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting cardiovascular diseases studies listed above.
- National Heart Institute · 3 studies
- Valley Clinical Trials · 3 studies
- Zuckerberg San Francisco General Hospital and Trauma Center · 3 studies
- Cardiovascular Research Foundation of Southern California · 2 studies
- Cedars-Sinai Medical Center · 2 studies
- Interventional Cardiology Medical Group · 2 studies
- The Lundquist Institute at Harbor-UCLA Medical Center · 2 studies
- University of California, Davis · 2 studies
What taking part in a cardiovascular diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Cardiovascular Diseases trials in other states
Common questions
- Are there cardiovascular diseases clinical trials in California?
- Yes. We're currently tracking 51 recruiting cardiovascular diseases studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a cardiovascular diseases study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a cardiovascular diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New cardiovascular diseases studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.