Clinical trials
Central Nervous System Diseases clinical trials
Below are recruiting central nervous system diseases clinical trials, each written for real people, not researchers. We’re tracking 208 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04771520RecruitingPhase 2
Avapritinib for tumors with specific KIT or PDGFRA changes
This Phase 2 trial studies avapritinib, a targeted medicine, for people whose cancer has specific KIT or PDGFRA genetic changes. It may help shrink or slow growth of certain advanced cancers, including some brain tumors, when standard treatments have not worked or for specific glioblastoma cases.
Houston, TexasAges 18 years+ - NCT04800484Recruiting
Test how different AFO heel height and stiffness affect walking
This study looks at how changing the heel height and stiffness of an AFO (a brace you wear on your lower leg/foot) changes your walking pattern. The goal is to learn which brace settings may improve comfort and walking.
Iowa City, IowaAges 18–70 - NCT04870944RecruitingPhase 1/Phase 2
CBL0137 for children with advanced solid or brain tumors
This early-phase study tests CBL0137 in children and teens whose cancer has come back or is not responding to treatment. It is also for some specific hard-to-treat brain tumors, to see if the drug is safe and can work against the cancer.
Birmingham, AlabamaAges 1–21 - NCT07698899RecruitingPhase 1
Study of a new treatment for childhood brain and CNS cancers
This trial tests a radioactive drug (177Lu-DTPA-Omburtamab) given directly into the fluid around the brain for children and teens with certain brain cancers or cancers that have spread to the central nervous system. It aims to see if this treatment is safe and effective for tumors that have come back or not responded to other therapies.
Basking Ridge, New JerseyAges 3–22 - NCT04961515RecruitingPhase 2
Orelabrutinib with immunotherapy and temozolomide for CNS lymphoma
This Phase 2 trial studies a combination of anti-cancer medicines to treat lymphoma that is only in the brain/spinal fluid (central nervous system, or CNS), especially when it has come back or not responded. If you qualify, you may benefit from improved tumor control and possibly better symptom control.
Hangzhou, ZhejiangAges 18–75 - NCT05056740Recruiting
Inflammatory markers for CNS autoimmune disease diagnosis
This trial studies whether certain inflammatory biomarkers in blood and spinal fluid can help diagnose autoimmune diseases affecting the brain and spinal cord. It may help people who are undergoing testing for white matter lesions.
NiceAges Any age - NCT05131022RecruitingPhase 1
Study of NX-5948 for relapsed B-cell blood cancers
This Phase 1 study tests NX-5948 in adults whose B-cell cancers have come back or did not respond to prior treatment. It aims to find a safe dose and see how well the treatment works in different types of B-cell malignancies.
Duarte, CaliforniaAges 18 years+ - NCT05209620RecruitingPhase 2
Orelabrutinib plus pemetrexed for lymphoma in the brain
This Phase 2 trial tests a combination medicine (orelabrutinib with pemetrexed) to treat lymphoma that has returned or is not responding, specifically in the brain or spinal fluid. If you qualify, the goal is to shrink measurable tumors and improve control of central nervous system lymphoma.
Zhengzhou, HenanAges 18–75 - NCT05212129Recruiting
Stimulation of the ear nerve to help gut symptoms
This study tests whether stimulating a nerve in the ear (called auricular vagal nerve stimulation) can improve upper gut symptoms in teens who may have hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobile spectrum disorder (HSD). It also checks whether this treatment helps nerves that control the body (autonomic nervous system) and how well the gut moves.
Milwaukee, WisconsinAges 10–18 - NCT05235074RecruitingPhase 1/Phase 2
Oncolytic virus treatment for recurrent brain tumors after surgery
This early-phase study tests an oncolytic virus—an anti-cancer virus—given into the brain to treat recurrent brain tumors after surgery. It aims to shrink tumors or slow their growth by directly targeting cancer cells in the brain.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05349006RecruitingPhase 3
Azathioprine for first attack in MOG antibody disease
This Phase 3 trial studies whether azathioprine can help prevent problems after a first attack of MOG antibody–related inflammation of the brain/spinal cord. It’s for adults with a recent first episode and confirmed MOG antibodies.
BordeauxAges 18 years+ - NCT05386108RecruitingPhase 1/Phase 2
Test abemaciclib plus elacestrant for breast cancer brain spread
This trial studies whether the combination of abemaciclib and elacestrant can slow or shrink ER-positive, HER2-negative breast cancer that has spread to the brain. It is designed for people whose cancer has progressed despite prior hormone (endocrine) treatment.
Fullerton, CaliforniaAges 18 years+ - NCT05600660RecruitingPhase 2
Testing a new combo treatment for newly diagnosed brain lymphoma
This trial tests a combination of orelabrutinib, rituximab, and methotrexate in people with newly diagnosed primary CNS lymphoma (a lymphoma mainly in the brain/spinal fluid). The goal is to see how well the treatment works and how safely it can be given.
Hanzhou, ZhejiangAges 18–75 - NCT05625594RecruitingPhase 1
Test brain-directed CAR T cells for CNS lymphoma
This Phase 1 study tests a new type of immune therapy (CAR T cells) placed directly into the fluid around the brain to treat central nervous system (CNS) lymphoma. It mainly looks at safety and how well the treatment can control the lymphoma when other CNS treatments have not worked.
Duarte, CaliforniaAges 18 years+ - NCT05681195RecruitingPhase 2
Zanubrutinib plus pemetrexed for recurrent brain lymphomas
This trial tests zanubrutinib (a targeted lymphoma medicine) together with pemetrexed (chemotherapy) for lymphoma that has come back or did not respond well in or around the brain. It may help shrink measurable lymphoma and improve control of disease after prior treatments.
Miami, FloridaAges 18 years+ - NCT05725499Recruiting
Check if skin stimulation lowers blood pressure drops after spinal injury
This study tests a skin “stimulation” treatment to see if it helps stabilize blood pressure in people with spinal cord injury who get low blood pressure when sitting up. If you often have dizziness, faintness, or low readings after changing positions, this trial may help find safer ways to manage it.
West Orange, New JerseyAges 18–75 - NCT05731986Recruiting
Skin nerve stimulation to raise blood pressure after spinal injury
This study tests whether a device that delivers mild electrical stimulation through the skin can improve low blood pressure after an acute spinal cord injury. It may help reduce episodes of dizziness or faint-feeling caused by blood pressure dropping when you sit up.
West Orange, New JerseyAges 18–75 - NCT05886114Recruiting
Lifestyle program to help older adults at risk of memory decline
This trial tests a multi-part lifestyle program to help older adults who may be starting to decline in thinking and memory. It may help slow cognitive decline by combining lifestyle changes over 24 months.
Hangzhou, ZhejiangAges 60–80 - NCT05892510RecruitingPhase 2/Phase 3
Tenecteplase after clot removal for no-reflow stroke
This trial tests whether giving tenecteplase directly into the brain artery after a thrombectomy can improve outcomes when blood flow doesn’t fully return (“no-reflow”) in an emergency stroke. It may help some people by reducing ongoing clot-related blockage after the main clot is removed.
Gold Coast, QueenslandAges 18 years+ - NCT05903235Recruiting
VR and mirror therapy for arm recovery after stroke
This trial tests a mix of virtual reality (VR) and mirror therapy to help improve arm movement after a stroke. You may be asked to use the technology and give feedback, and the study may compare it with other care approaches to see if it helps more.
Taoyuan CityAges 20–80 - NCT05931328RecruitingPhase 2
Thiotepa plus pomalidomide for recurrent brain lymphoma
This Phase 2 trial tests a combination medicine (thiotepa plus pomalidomide) for people whose primary central nervous system lymphoma has come back or did not respond to prior chemotherapy. It may help shrink lymphoma in the brain/spinal fluid and improve disease control.
Nanjing, JiangsuAges 18–75 - NCT05968976Recruiting
DBS surgery guided while awake versus asleep for essential tremor
This study compares two ways of doing a deep brain stimulation (DBS) procedure for people with essential tremor: using guidance while you are awake versus while you are asleep. It aims to find which approach is safer and works better for controlling disabling tremor.
Amsterdam, North HollandAges 18 years+ - NCT06048523Recruiting
Study of genetic brain diseases
This study follows people with a confirmed genetic nerve or brain disease over time, collecting blood and sometimes spinal fluid samples to learn more about the condition. It may help researchers understand how the disease progresses.
BordeauxAges 6 years+ - NCT06053619Recruiting
Virtual reality walking rehab for stroke patients who cannot walk
This trial tests whether adding virtual reality to robot-assisted walking therapy helps people who have had a stroke and cannot walk. It is for patients who had a first stroke in the past 15 days to 6 months.
LimogesAges 35–75
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Common questions
- Are there clinical trials for central nervous system diseases?
- Yes. Clin2 currently lists 208 recruiting central nervous system diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a central nervous system diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a central nervous system diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.