Clinical trials
Chemoradiation clinical trials
Below are recruiting chemoradiation clinical trials, each written for real people, not researchers. We’re tracking 93 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06563479RecruitingPhase 3
Personalized vs. standard radiation for HPV-positive throat cancer
This trial compares a personalized, shorter course of radiation therapy to the standard longer course for people with HPV-positive throat cancer. The goal is to see if personalized treatment is just as effective while reducing side effects.
Hartford, ConnecticutAges 18 years+ - NCT07219212RecruitingPhase 1
New drug with chemo and radiation for advanced head and neck cancer
This study tests if adding an investigational drug called JNJ-90301900 to standard chemotherapy and radiation therapy works better for people with certain advanced head and neck cancers (like mouth, throat, and voice box) that have not spread to other parts of the body.
Birmingham, AlabamaAges 18–74 - NCT06191133RecruitingPhase 1
Fenofibrate for cervical pre-cancer and cancer
This study tests whether a cholesterol-lowering drug called fenofibrate can help people with cervical pre-cancer or cancer. You take the drug before your scheduled surgery or chemoradiation, and doctors check if it reduces abnormal tissue or enhances treatment.
Cleveland, OhioAges 18 years+ - NCT02972372Recruiting
Compare chemoradiation with surgery for esophageal cancer
This study compares two treatment approaches for certain locally advanced esophageal cancers: chemoradiation (chemo plus radiation) versus esophagus surgery. It may help find which option works better to control the cancer and improve outcomes.
Anyang, HenanAges 18–75 - NCT03249519Recruiting
Radiation plus heat for advanced cervical cancer
This trial studies whether adding controlled heat (“hyperthermia”) to radiation therapy (or radiation with chemotherapy) can improve outcomes in advanced cervical cancer. It focuses on people who can safely receive intensive pelvic radiation and heat treatment.
ErlangenAges 18 years+ - NCT03322995RecruitingPhase 2
Neoadjuvant chemo study for resectable pancreatic cancer
This Phase 2 trial tests a chemotherapy plan given before surgery (called “neoadjuvant” treatment) for people with pancreatic adenocarcinoma that looks resectable or borderline resectable on scans. The goal is to see how well this adaptive chemotherapy approach works and whether it can improve outcomes before an operation.
Milwaukee, WisconsinAges 18 years+ - NCT03516708RecruitingPhase 1/Phase 2
Epacadostat with pre-op radiation for locally advanced rectal cancer
This trial studies whether adding epacadostat (a cancer drug) to standard pre-operative chemoradiation can improve outcomes for people with locally advanced rectal cancer. It’s designed to see if the added treatment is safe and potentially more effective before surgery.
Orange, CaliforniaAges 18 years+ - NCT03731442RecruitingPhase 3
Radiation plus chemotherapy for esophageal cancer that came back
This Phase 3 trial studies giving combined chemotherapy and radiation to treat esophageal cancer that has returned after earlier surgery and/or prior treatments. It may help control the cancer in the area where it comes back, especially when the surgical margins were not fully clear or the cancer is outside the original radiation field.
Beijing, Beijing MunicipalityAges 16–70 - NCT03853915Recruiting
PET scan and HPV testing during chemoradiation for cervical cancer
This study looks at whether a PET scan (FDG-PET/CT) and blood HPV testing can help track cervical cancer responses during and after standard chemo-radiation. It may help doctors better understand who is responding and who may need different care.
Toronto, OntarioAges 18 years+ - NCT03919552RecruitingPhase 3
Chemoradiation with two cisplatin or carboplatin plans for nasopharyngeal cancer
This Phase 3 trial compares two chemotherapy-and-radiation combinations (cisplatin-based vs carboplatin-based) for locally advanced nasopharyngeal cancer that has not spread to distant organs. It may help researchers find which plan works best while balancing safety and effectiveness.
Guangzhou, GuangdongAges 18–64 - NCT04006561Recruiting
Brain lymphoma study using targeted whole-brain radiation
This trial studies how newly diagnosed primary central nervous system (brain) non-Hodgkin lymphoma responds to a specific type of radiation to the whole brain, and it also looks at changes in thinking, mood, and behavior. It may help doctors understand how this treatment affects day-to-day brain function.
TaoyuanAges 18–80 - NCT04138212RecruitingPhase 3
Chemo alone vs chemo with radiation before esophagus surgery
This study compares chemotherapy alone versus chemotherapy plus radiation given before surgery for locally advanced esophagus squamous cell cancer. The goal is to see which treatment helps more people have a successful operation and better cancer control.
Zhengzhou, HenanAges 18–70 - NCT04481256Recruiting
Immunotherapy with chemoradiation for esophageal cancer
This trial tests adding medicines that block TGF-beta and PD-L1 to standard chemoradiation for esophageal squamous cell cancer that can’t be removed with surgery. It aims to improve control of the cancer where it sits, while keeping treatment safe.
AmsterdamAges 18 years+ - NCT04680377Recruiting
Using gut microbes to predict durvalumab side effects in lung cancer
This study looks at the microbiome (the tiny organisms in your gut) to try to predict who will get side effects from durvalumab after chemoradiation. If you join, your care team will use your microbiome results to help understand toxicity risk and improve future treatment planning.
Kansas City, KansasAges 18 years+ - NCT04821843RecruitingPhase 3
Study before-surgery treatments for esophageal cancer
This Phase 3 trial compares different “treatments before surgery” for people with esophageal (or esophagus-to-stomach) cancer. It aims to see which approach works better to control the cancer and improve outcomes after surgery.
BeijingAges 18 years+ - NCT04821778RecruitingPhase 3
Testing chemoradiotherapy for esophageal and stomach junction cancer
This Phase 3 study tests a cancer treatment plan that combines chemotherapy and radiation for people with esophageal or esophagus-stomach junction cancer. It aims to see whether this approach works better than standard care for cancers at stages I to IVA.
Anyang, HenanAges 18 years+ - NCT04852328RecruitingPhase 2
Testing CUE-101 schedules before treatment for HPV16 throat cancer
This Phase 2 trial studies different timing “schedules” of CUE-101 given before surgery or before chemoradiation for HPV16-positive oropharyngeal throat cancer. The goal is to see if CUE-101 can help the body respond better and potentially improve outcomes.
St Louis, MissouriAges 18 years+ - NCT04892953RecruitingPhase 2
Durvalumab plus focused radiation for progressing stage III lung cancer
This trial studies adding focused radiation to some cancer spots in people with stage III non-small cell lung cancer (NSCLC) whose cancer did not fully stop after standard chemoradiation and durvalumab. The goal is to control a small number of growing spots (or more than a few) and improve outcomes after durvalumab.
Houston, TexasAges 18 years+ - NCT04951635RecruitingPhase 3
Almonertinib after chemoradiation for stage III lung cancer
This Phase 3 trial tests whether almonertinib given after standard chemoradiation can help people with stage III, non-surgical lung cancer live longer and/or control the cancer. It is for tumors with specific EGFR mutations linked to sensitivity to EGFR-targeted medicines.
Ji'nan, ShandongAges 18 years+ - NCT05000697Recruiting
Watch-and-wait or chemo after rectal cancer radiation
This trial studies people with early-to-mid stage distal rectal cancer who may get radiation and chemotherapy, with an option that may include an extra drug (oxaliplatin). It also tests whether some people can safely follow a “watch and wait” plan instead of immediate additional treatment, aiming to reduce overtreatment while keeping cancer control.
Buenos AiresAges 18 years+ - NCT05010109Recruiting
Testing heart safety and fitness during lung cancer chemoradiation
This study looks at how lung cancer treatment affects the heart and whether a “walking test” and blood tests can track heart fitness and injury. It may help by improving how cancer therapy is planned and monitored for heart safety.
Houston, TexasAges 18 years+ - NCT05027633RecruitingPhase 2
Immunotherapy plus chemo and radiation for nasal cancer
This Phase 2 study tests a treatment plan that combines immunotherapy with chemotherapy and chemoradiation for advanced squamous cell cancer in the nasal cavity or sinuses. It aims to improve cancer control in people who are newly diagnosed and have not had prior treatment for this cancer.
Houston, TexasAges 18 years+ - NCT05173272RecruitingPhase 3
Immunotherapy plus chemo, then radiation, for advanced cervical cancer
This study tests whether adding immunotherapy to chemotherapy, then giving chemotherapy together with radiation, works better for advanced cervical cancer. It aims to improve cancer control and help people live longer, without major safety issues.
Chengdu, SichuanAges 18 years+ - NCT05179447Recruiting
Study testing added treatment after endometrial cancer surgery
This trial looks at how to guide follow-up (adjuvant) treatment after surgery for certain early-stage, higher-risk endometrial cancer. It may help by tailoring care based on patient and tumor details to lower the chance of the cancer coming back.
Wuhan, HubeiAges 18–75
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Common questions
- Are there clinical trials for chemoradiation?
- Yes. Clin2 currently lists 93 recruiting chemoradiation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chemoradiation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chemoradiation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.