Clinical trials
Chronic Heart Failure clinical trials
Below are recruiting chronic heart failure clinical trials, each written for real people, not researchers. We’re tracking 397 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07325942Recruiting
Low vs high volume high-intensity interval training for heart failure
This study compares two different types of high-intensity interval exercise programs (one shorter, one longer) in people with chronic heart failure. It aims to see which program improves heart health and daily function more.
Cairo, Giza GovernorateAges 18 years+ - NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Little Rock, ArkansasAges 50 years+ - NCT07265349RecruitingPhase 1/Phase 2
Stem cells plus bypass surgery for chronic heart failure
This trial tests whether injecting stem cells from umbilical cord tissue into the heart muscle during bypass surgery can improve heart function in people with chronic heart failure. It is for patients who are already scheduled for bypass surgery and have a weakened heart pump (LVEF between 21% and 40%).
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05715697Recruiting
Kidney artery treatment for heart failure with normal heart pumping
This study tests whether renal denervation (a procedure to reduce overactive signals in kidney arteries) can help people who have heart failure but keep a normal pumping ability and still have high blood pressure. It aims to improve blood-pressure control and heart function in this specific group.
Ürümqi, XinjiangAges 21–80 - NCT06595290Recruiting
Faster medication increase for heart failure with weak pumping
This trial tests a new, faster way to increase heart failure medications during a hospital stay, aiming to get patients on the right doses sooner. It is for people with weak heart pumping (ejection fraction 40% or less) who are currently in the hospital for heart failure and are on low doses of standard medications.
Long Xuyen, An GiangAges 18–75 - NCT06360380Recruiting
Wearable device for fluid removal in heart failure
This trial tests a wearable device that removes extra fluid from your body without using the kidneys. It may help people with heart failure who still have fluid buildup despite taking high doses of water pills.
La Jolla, CaliforniaAges 21–79 - NCT07682298Recruiting
Measuring leftover fluid in hospitalized heart failure patients
This study looks at how well we can measure leftover fluid in the body in people hospitalized for heart failure with fluid overload. It aims to help doctors better manage treatment and improve recovery.
AarhusAges 18 years+ - NCT06706791RecruitingPhase 4
Empagliflozin for heart failure & diabetes: quality of life study
This trial tests whether a diabetes medicine called empagliflozin can improve the quality of life for people who have both chronic heart failure with a weak heart pump and type 2 diabetes. It compares the effects of adding empagliflozin to your current treatments.
Karachi, SindhAges 40–70 - NCT06258447Recruiting
CardiAMP bone marrow cell therapy for heart failure
This trial tests a new treatment using your own bone marrow cells to help your heart pump better. It's for people with heart failure after a heart attack whose heart function is moderately reduced.
Clearwater, FloridaAges 21–90 - NCT04471129Recruiting
Noninvasive breathing support after heart surgery to protect heart function
This study tests whether two noninvasive breathing/oxygen treatments after cardiac surgery help improve heart function. It may benefit people with weak pumping function who are recovering in the hospital and can safely use these devices.
RouenAges 18 years+ - NCT04180085RecruitingPhase 2
Belatacept to protect kidneys in heart transplant patients
This trial studies whether belatacept can be used after a heart transplant to help protect kidney function over time. It focuses on people who already have (or are at risk for) worsening kidney function after transplant, while avoiding those with certain infections or rejection concerns.
BordeauxAges 18 years+ - NCT07650474Recruiting
Mobile app for heart failure management and quality of life
This study tests whether using a mobile phone app to monitor and manage chronic heart failure improves how you feel and function day-to-day. Researchers will check in with you regularly through your phone to track your symptoms and health.
Addis AbabaAges 18–65 - NCT06036615Recruiting
Exercise training for frailty and fall risk in heart failure
This trial tests whether a supervised exercise program can reduce frailty and fall risk in people with chronic heart failure, and what happens when training stops. It may help you feel stronger and more stable.
Thessaloniki, ThermiAges 18–100 - NCT06148935Recruiting
Study of vericiguat in Korean heart failure patients
This study looks at how well Verquvo (vericiguat) works in daily life for Korean adults with chronic heart failure and a weak heart pump. It’s for people whose heart failure has recently gotten worse and who are starting Verquvo for the first time.
Multiple LocationsAges 19 years+ - NCT07434193Recruiting
Pacing study after aortic valve replacement
This trial tests if special pacing of the heart's lower chambers (called cardiac resynchronization therapy, or CRT) can help people who develop a new electrical delay in the heart after having a transcatheter aortic valve replacement (TAVI). The study compares two types of pacing to see which works better for recovery.
BudapestAges 18 years+ - NCT07083011RecruitingPhase 2
PET scan study for heart failure and cardiac sarcoidosis
This study uses a special PET scan (68Ga-FAPI) to look at inflammation in the heart. It may help researchers understand heart failure and cardiac sarcoidosis better.
Rochester, MinnesotaAges 18 years+ - NCT07057323Enrolling by invitation
Coronary sinus reducer for heart failure with preserved pumping function
This trial tests a device placed in a heart vein to improve symptoms in people whose heart pumps normally but still causes shortness of breath and fatigue. The device may help relieve pressure in the heart and improve daily life.
Rochester, MinnesotaAges 18 years+ - NCT07467668Recruiting
Iron infusion for heart failure patients with low iron
This trial tests whether giving intravenous iron to adults hospitalized with heart failure and low iron levels helps improve their health. You may be eligible if you have heart failure with reduced pumping function and low iron stores.
Pleasanton, CaliforniaAges 18 years+ - NCT07581587Recruiting
Breathing Exercises and Brain Function in Heart Failure
This study tests whether special breathing exercises—done alone or while doing a mental task—can improve memory and thinking skills in people with heart failure. Researchers want to see if training your breathing muscles helps your brain work better.
Istanbul, FatihAges 40 years+ - NCT07705269Recruiting
High-rate fluid removal for fluid overload in dialysis patients
This trial tests whether a faster rate of fluid removal during dialysis can help hospitalized patients with end-stage kidney disease who have severe fluid buildup. It aims to reduce fluid congestion and improve outcomes.
Monterrey, Nuevo LeónAges 18 years+ - NCT03772275Recruiting
Tests new blood markers in chronic heart failure patients
This study looks at whether certain new blood tests (biomarkers) can help doctors learn more about chronic heart failure. You might be asked for blood samples and health information, and the results could improve how heart failure is understood in the future.
Tanta, ElgharbiaAges 18–75 - NCT03945968Recruiting
Risk scores after abdominal surgery for people with health conditions
This study looks at how other health problems affect the chance of postoperative complications after abdominal surgery. It aims to help doctors better predict risk and decide on the safest care for you.
ArkhangelskAges 18 years+ - NCT07701876Recruiting
Heart failure recovery markers study
This study looks for markers in the blood that can predict whether the heart's pumping function improves in people with chronic heart failure. It may help doctors understand which treatments work best for each person.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT04149743Recruiting
Testing a heart-watching patch to track short-term heart failure outcomes
This trial checks whether a medical patch called HEMOTAG can help doctors predict or track how patients do shortly after a hospital stay for worsening heart failure. It may help improve early monitoring and treatment decisions after discharge.
Weston, FloridaAges 22 years+
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Common questions
- Are there clinical trials for chronic heart failure?
- Yes. Clin2 currently lists 397 recruiting chronic heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.