Clinical trials
Chronic Heart Failure clinical trials
Below are recruiting chronic heart failure clinical trials, each written for real people, not researchers. We’re tracking 396 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04986332Recruiting
Program for COPD or heart failure in people with other illnesses
This trial studies a detailed, whole-body program to improve outcomes in people with COPD or heart failure, especially those who also have several other chronic conditions. It may help by improving activity and monitoring health markers over about 24 weeks.
PalermoAges 45–75 - NCT05029570Recruiting
Heart rate control for permanent atrial fibrillation and heart failure
This trial studies whether a strategy to regularize (control) heart rate can improve outcomes in people who have permanent atrial fibrillation and heart failure. It focuses on people with recent heart-failure hospitalization and checks several heart, kidney, and health-condition limits to keep the study safe.
Madrid, MadridAges 18 years+ - NCT05292716Recruiting
MitraClip for advanced heart failure with leaky mitral valve
This trial studies whether the MitraClip procedure can improve outcomes for people with advanced heart failure caused by significant leakage of the mitral valve. It focuses on people who still have severe symptoms and poor quality of life despite the best available heart medications.
Brescia, LombardyAges 18–90 - NCT05448833Recruiting
Testing a wireless sensor to monitor left heart pressure
This study tests whether a small wireless sensor can safely measure and track pressure in the left upper heart chamber in people with advanced chronic heart failure. It may help the care team better understand pressure changes that are linked to fluid buildup and symptoms, alongside your usual heart medicines.
Petah TikvaAges 22–88 - NCT05486000Recruiting
Testing a device to help chronic left heart failure
This trial studies a small implant (an “atrial shunt” device) to improve symptoms and heart function in people with chronic left heart failure that stays active despite standard medicines. It focuses on whether the implant is safe and can help you feel better and possibly breathe easier.
Nantong, JiangsuAges 18 years+ - NCT05577819Recruiting
Screening for ATTR heart amyloid in older HFpEF patients
This study looks at how often a specific heart condition (ATTR amyloid) occurs in people age 65+ who have HFpEF. It also tries to predict who might have it, using a special heart scan, and may help your care team identify it earlier.
Boston, MassachusettsAges 65 years+ - NCT05647213RecruitingPhase 1
Skin biopsy study of stem-cell therapy for congenital heart disease
This early study takes a small skin sample to make a personalized type of heart stem cells in the future. It is testing whether this approach is safe and feasible for people with complex single-chamber congenital heart disease and advanced heart failure.
Rochester, MinnesotaAges 18–40 - NCT05650541Recruiting
Testing a home device to help chronic heart failure
This study tests whether a CardioPulmonary Management (CPM) system device used at home is safe and can improve outcomes for people with chronic heart failure. It may help manage symptoms and reduce complications, especially for higher-risk patients.
Palm Springs, CaliforniaAges 18 years+ - NCT05696652Recruiting
Exercise training study for people with heart failure
This study looks for blood and other markers that can explain how people with heart failure respond to exercise training. It may help researchers better tailor exercise or treatment plans for heart failure in the future.
Stanford, CaliforniaAges 18–89 - NCT05770349Recruiting
Heart failure patients having bypass surgery are studied
This study looks at tiny structures inside heart muscle cells (especially “power stations” in the cells) in people with certain types of heart failure who are getting coronary bypass surgery. It may help researchers better understand what changes happen in the heart and how this could guide future care.
TomskAges 18 years+ - NCT05859048Recruiting
Care plan to help high-risk people spot heart failure early
This trial tests a multidisciplinary care approach aimed at helping people with high risk for heart failure get diagnosed earlier. It may help you catch heart failure sooner if it starts, so treatment can begin earlier.
Vancouver, British ColumbiaAges 40 years+ - NCT05873881RecruitingPhase 3
Colchicine and vitamin B1 for ischemic heart failure
This study tests whether colchicine and thiamine (vitamin B1) can improve outcomes in people with heart failure caused by blocked or narrowed heart arteries. It’s mainly for people with moderate-to-severe symptoms and reduced heart pumping ability.
Hamilton, OntarioAges 45 years+ - NCT05873634Recruiting
Using health records and testing to study heart failure types
This study combines electronic health record data and detailed heart testing to better understand different heart failure types and what treatments may work best for each. It mainly enrolls people with known heart failure, and also some people without heart failure for comparison.
Sacramento, CaliforniaAges 30 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT05934565Recruiting
Using mindfulness coaching to help people move more
This trial studies a program that uses mindfulness coaching to help people with chronic lung disease (COPD) and/or heart failure (HF) be more physically active. You may benefit if you can safely start exercising and track your steps using a Fitbit.
Boston, MassachusettsAges 40 years+ - NCT05936957Recruiting
Heart failure care study for acute and chronic patients
This study welcomes people with heart failure (both sudden/worsening and long-term). It will check how heart failure care is managed, and it only moves forward if you choose to participate.
Ibadan, Oyo StateAges 18–100 - NCT05960890Recruiting
Study of chronic heart failure after hospital discharge
This study follows adults with chronic or newly diagnosed heart failure to learn how patients do after they leave the hospital, mainly while taking heart medicines by mouth. It may help researchers better understand which patients have different outcomes and needs.
Taizhou, JiangsuAges 18 years+ - NCT06006819Recruiting
Acute heart failure with chronic kidney disease study
This trial studies how certain markers in the blood can predict outcomes in people with acute heart failure who also have chronic kidney disease. If you qualify, researchers will follow your health during this hospital stay.
Taipei, Baitou DistrictAges 20–90 - NCT06015776Recruiting
Heart cell signals after menopause
This trial studies how heart cells communicate after menopause. Researchers are looking at a chemical signal called purinergic signaling during heart surgery.
Boston, MassachusettsAges 30–88 - NCT06032780Recruiting
Exercise training for chronic heart failure
This study tests if a specific type of leg-strengthening exercise (eccentric resistance training) can help people with stable chronic heart failure feel better and move more easily. If you have heart failure and are not in an acute or very severe stage, this might be an option to improve your daily life.
Rawalpindi, Punjab ProvinceAges 18 years+ - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT06205225Recruiting
Mobile health program for heart failure self-care
This study tests a mobile health program (phone app and coaching) to help people with heart failure better manage their condition at home. It aims to improve self-care and reduce hospital visits.
Chicago, IllinoisAges 18 years+ - NCT06222099Recruiting
Heartfelt study for chronic heart failure with swelling and adherence challenges
This trial tests a program to help people with chronic heart failure who have swelling in their feet and legs and struggle to follow their care plan. It aims to reduce hospital visits by improving daily monitoring and medication use.
Little Rock, ArkansasAges 22 years+ - NCT06222762Recruiting
Personalized exercise follow-up for chronic heart failure
This study tests whether a personalized exercise program can help people with chronic heart failure feel better and stay active. It is for patients who are already in a cardiac rehab program and have stable heart failure.
BrestAges 18–80
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Common questions
- Are there clinical trials for chronic heart failure?
- Yes. Clin2 currently lists 396 recruiting chronic heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.