Clinical trials
Chronic Kidney Disease Stage 4 clinical trials
Below are recruiting chronic kidney disease stage 4 clinical trials, each written for real people, not researchers. We’re tracking 147 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06656988RecruitingPhase 3
Saving kidney function during leg artery treatment with carbon dioxide
This trial tests if using carbon dioxide gas instead of standard dye during a leg artery procedure can protect the kidneys. It is for people with blocked leg arteries who also have reduced kidney function.
InnsbruckAges 18 years+ - NCT05159466Recruiting
Transplant from HIV-positive donors to HIV-positive recipients
This trial studies whether it’s safe and effective for HIV-positive people to receive organ transplants from HIV-positive donors. It focuses on matching HIV treatment before and after transplant and checking for major complications.
Metairie, LouisianaAges 18 years+ - NCT06330246Recruiting
Study on gut bacteria for calcium kidney stones
This study looks at whether a specific gut bacteria called Oxalobacter formigenes can help people who form calcium oxalate kidney stones. You will eat a controlled diet and provide samples to see how your body handles oxalate, a substance that can lead to stones.
Birmingham, AlabamaAges 18–70 - NCT06878560RecruitingPhase 1/Phase 2
Pig kidney transplant for kidney failure patients
This trial tests a special pig kidney (10 GE Xenokidney) as a transplant option for people with kidney failure who cannot get a human kidney. It aims to offer a life-saving alternative.
Chicago, IllinoisAges 40–70 - NCT06989320Recruiting
Oxalate production in calcium oxalate stone formers
This study looks at how the body makes oxalate (a natural substance that can form kidney stones) in people who have had calcium oxalate stones. You will eat a special diet and stop supplements for a short time to help researchers understand stone formation.
Birmingham, AlabamaAges 18–80 - NCT07224763RecruitingPhase 1/Phase 2
Pig kidney transplant trial for kidney failure patients
This trial tests a genetically modified pig kidney (Thymokidney) for people with end-stage kidney disease who are on dialysis. It aims to see if this new type of transplant is safe and effective for those who cannot get a human kidney.
New York, New YorkAges 40–70 - NCT06283966RecruitingPhase 3
Triple inhaler for COPD with heart risk
This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) to see if it can help protect the heart and lungs in people with COPD who also have heart problems or high risk for them.
Athens, AlabamaAges 40–80 - NCT04037995Recruiting
Real-world study of advanced liver disease in China
This study looks at people with very advanced liver problems to better understand what happens in real life. It may help doctors improve care for advanced cirrhosis and certain liver cancers.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07352800RecruitingPhase 2
Study of APAC for peripheral artery disease and severe leg ischemia
This trial tests a new drug called APAC to see if it safely prevents blood clots and improves blood flow in people with narrowed leg arteries. It may help those with severe symptoms like pain at rest or non-healing wounds, or those with claudication (leg pain when walking).
HelsinkiAges Up to 85 years - NCT07630545RecruitingPhase 1
Testing a new drug for Parkinson's disease
This study tests an experimental drug, MTX325, in people with Parkinson's disease. The goal is to see if it is safe and how the body processes it, which may lead to new treatment options.
AdelaideAges 18–75 - NCT06491043RecruitingPhase 2
Stem cells for COPD: safety and early effectiveness study
This trial tests whether an infusion of donor stem cells can help people with moderate to severe COPD breathe easier. If you are a current or former smoker aged 40 to 80, your symptoms are stable, and your lung function meets specific targets, you may be able to join.
New Taipei CityAges 40–80 - NCT06331546Recruiting
Gut oxalate absorption in calcium oxalate stone patients
This study looks at how much oxalate (a substance in many foods) gets absorbed by the gut in people who form calcium oxalate kidney stones. You will eat a controlled diet and provide urine and blood samples over a few days.
Birmingham, AlabamaAges 18–70 - NCT07492511Recruiting
Ultrasound patterns in kidney and liver after trauma
This trial uses special ultrasound (Doppler) to look at blood flow in the kidneys and liver after a serious injury. It aims to find patterns that could help doctors better understand and treat trauma patients.
BolognaAges 18–65 - NCT06056102RecruitingPhase 1
CAR-T cell therapy to help highly sensitized kidney transplant patients
This trial tests whether a special immune cell treatment (CAR-T cells) can lower the antibodies that make it very hard for you to receive a kidney transplant. If it works, you might become eligible for a transplant sooner.
Boston, MassachusettsAges 18–65 - NCT06842966RecruitingPhase 2
Testing a new tablet for chronic gallbladder issues
This trial tests an investigational tablet for people with long-term gallbladder inflammation (chronic cholecystitis) or bile duct movement problems (biliary dyskinesia). It aims to see if the tablet reduces stomach pain and other digestive symptoms.
Engel'sAges 18–70 - NCT06850597RecruitingPhase 2
Testing dimethyl fumarate for early Alzheimer's disease
This study tests a drug called dimethyl fumarate to see if it can help people with early Alzheimer's disease. It may slow down memory loss and thinking problems.
Lodz, Łódź VoivodeshipAges 55–90 - NCT02938611Recruiting
Study to estimate care needs for stage 4 kidney disease
This study aims to find out how common stage 4 kidney disease is in a specific area and how it is being managed. It may help doctors plan better care by improving local estimates and understanding current treatment approaches.
AlèsAges Any age - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT07595003RecruitingPhase 3
Testing a new medicine for gallbladder pain and discomfort
This study tests whether a medicine called 4-MUST can safely reduce pain and digestive symptoms caused by chronic gallbladder problems. You'll take tablets for several weeks while researchers track how well the medicine works and any side effects.
MoscowAges 18–70 - NCT06483074RecruitingPhase 2
Empagliflozin to preserve kidney function in new peritoneal dialysis patients
This trial tests whether empagliflozin, a medication originally for diabetes, can help protect the remaining kidney function in people who have just started peritoneal dialysis. If you started dialysis within the last 3 months and still make some urine, this study may be a good fit.
Hong KongAges 18–75 - NCT07672977Enrolling by invitation
Sound therapy at home to improve deep sleep in early Alzheimer's
This study tests whether a wearable device that plays soft sounds during sleep can boost deep sleep brain waves in people with mild memory problems caused by Alzheimer's. It aims to see if this simple, home-based approach can help protect memory and thinking.
Zaragoza, ZaragozaAges 50–75 - NCT05508009RecruitingPhase 1/Phase 2
Kidney transplant with donor-matched stem cell treatment
This early-phase trial tests a stem cell transplant from a donor who is an extremely close match, given to people who are about to receive a kidney transplant from the same donor. The goal is to improve how well the new kidney works by resetting the immune system to better accept the transplant.
Palo Alto, CaliforniaAges 1–30 - NCT00977977RecruitingPhase 2
Rituximab plus cyclosporine for membranous kidney disease
This trial tests whether rituximab (an immune-targeting medicine) plus cyclosporine (another immune medicine) can better control protein leakage in the urine for people with idiopathic membranous nephropathy. It may help reduce long-lasting kidney damage risk when standard treatments like ACE inhibitor or ARB don’t control the protein level.
Bethesda, MarylandAges 18–90 - NCT07403669Recruiting
Heart, kidney, and metabolic health assessment study
This trial offers a health assessment and empowerment program for adults who have heart, kidney, or metabolic conditions like diabetes or heart disease. It aims to help you better manage your health.
Chandler, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for chronic kidney disease stage 4?
- Yes. Clin2 currently lists 147 recruiting chronic kidney disease stage 4 studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic kidney disease stage 4 trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic kidney disease stage 4 trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.