Clinical trials
Clinical High Risk clinical trials
Below are recruiting clinical high risk clinical trials, each written for real people, not researchers. We’re tracking 551 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04588922RecruitingPhase 1/Phase 2
Study drug SLS009 for high-risk leukemia in adults and teens
This early-phase study tests SLS009 (also called GFH009), a targeted medicine, to treat certain blood cancers—especially high-risk or difficult-to-treat AML. It’s designed to see how the drug works, how safe it is, and what dose may be best for you.
Birmingham, AlabamaAges 12 years+ - NCT07307560Recruiting
High-flow oxygen during sedation for sleep apnea patients having endoscopy
This study tests if high-flow nasal oxygen can prevent oxygen drops during sedated endoscopy in patients with severe obstructive sleep apnea. It may help people who are at higher risk of breathing problems during the procedure.
Hangzhou, ZhejiangAges 18 years+ - NCT07389616RecruitingPhase 2/Phase 3
Preventing lymphoma return after transplant
This trial tests a combination of two drugs (cidabenamine and azacitidine) to help prevent peripheral T-cell lymphoma from coming back after a donor stem cell transplant. It is for patients who are at high risk of progression and have already had a transplant.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06522256Recruiting
HPV and anal cancer risk 10 years later
This study looks at HPV (the virus that can cause anal cancer) and checks if certain types of high-risk HPV are linked to abnormal cells or cancer in the anus, 10 years after joining the IPERGAY trial. It helps researchers understand long-term risks.
LyonAges 18 years+ - NCT07206017Recruiting
Chicory root fiber for melanoma patients after surgery
This study tests whether adding a high-fiber chicory root supplement to your diet can help people after melanoma surgery. Researchers want to see if it improves your immune system and gut health to prevent the cancer from coming back.
Groningen, Provincie GroningenAges 18 years+ - NCT04433052Recruiting
Personalized heart-protection program for people at high risk
This trial tests whether a tailored prevention plan can improve outcomes and help with costs for people at high risk of coronary heart disease. You may join if you’ve had recent heart events or scans show significant blockage, and if you can follow the visit and app requirements.
HelsinkiAges 30–80 - NCT06672302Recruiting
Blood test to find high breast cancer risk
This study uses a blood test to help identify women who are at high risk for breast cancer. It is for Korean women aged 40 or older who have a suspicious breast finding and need a biopsy.
Honolulu, HawaiiAges 40 years+ - NCT05918263Recruiting
Exercise to slow prostate cancer in men on active surveillance
This trial tests whether moderate exercise can help keep low-risk prostate cancer from growing in men who are monitoring their cancer instead of treating it right away. It may be especially helpful for men with certain risk factors like obesity or being Black or African American.
Boston, MassachusettsAges 18 years+ - NCT07053059RecruitingPhase 2
CAR T-cell therapy to prevent relapse in high-risk B-cell ALL
This trial tests a new CAR T-cell therapy (obecabtagene autoleucel) given as a consolidation treatment after initial remission to prevent relapse in people with high-risk B-cell ALL. It's for patients who have achieved first remission but still have high-risk features in their leukemia.
Houston, TexasAges 18 years+ - NCT05807256Recruiting
Fertility treatments for people with immune system joint diseases
This trial looks at fertility (“medically assisted fertilization,” such as IVF) for people with certain immune-related rheumatology conditions (like lupus, rheumatoid arthritis, or vasculitis). It may help patients and their clinicians understand which fertility approach works best and is safe for this group.
MilanAges 18–50 - NCT07443306RecruitingPhase 2
Testing Flonoltinib for myelofibrosis after JAK inhibitor failure
This trial tests a new tablet, Flonoltinib, for people with medium-to-high risk myelofibrosis whose prior JAK inhibitor treatment stopped working, caused side effects, or wasn't tolerated. The goal is to see if this new drug can help reduce spleen size and improve symptoms.
Chengdu, SichuanAges 18–80 - NCT07665762RecruitingPhase 3
Numbing medicine for arm surgery pain prevention
This trial compares two additives to standard numbing medicine given before wrist fracture surgery to see which better prevents severe pain. You may qualify if you have risk factors for hard-to-control pain after surgery.
Hong KongAges 18–90 - NCT06667700RecruitingPhase 3
A study of the antiviral molnupiravir for high-risk people with COVID-19
This study tests an antiviral pill called molnupiravir to see if it can prevent severe COVID-19 in people who are at high risk and cannot take Paxlovid. If you have mild to moderate COVID-19 symptoms and certain health risks, you may be able to join.
Cullman, AlabamaAges 18 years+ - NCT06441110RecruitingPhase 3
BCG instillation for medium- to high-risk bladder cancer
This trial tests whether a specific schedule of BCG (a weakened germ that boosts the immune system) placed directly into the bladder is safe and effective for medium- to high-risk bladder cancer that hasn't grown into the muscle. It aims to see if adjusting the standard BCG course can work better for people with a PD-L1-positive tumor.
Fuzhou, FujianAges 18–75 - NCT07513376RecruitingPhase 3
Adjuvant vaccine plus immunotherapy for high-risk early lung cancer
This trial tests whether giving a personalized cancer vaccine (Intismeran) with or without an immunotherapy drug (pembrolizumab) after lung cancer surgery can help prevent the cancer from coming back in patients with early-stage, high-risk non-small cell lung cancer.
Sacramento, CaliforniaAges 18 years+ - NCT07372131Recruiting
Shorter antibiotics for high-risk fever with low white blood cells
This study looks at how long antibiotics should be given to cancer patients with fever and very low white blood cell counts after finding a certain type of bacteria (Gram-negative) in their blood. The goal is to find the best treatment duration to help patients recover without complications.
Rozzano, MilanAges 18 years+ - NCT07324096Recruiting
Screening for pancreatic cancer in people with new diabetes
This study screens people with recent diabetes who are at high risk for pancreatic cancer. It uses a CT scan to find cancer early, when it may be easier to treat.
Rochester, MinnesotaAges 50–85 - NCT06644937RecruitingPhase 2/Phase 3
TACE with Icaritin after surgery for high-risk liver cancer
This trial tests combining a targeted medicine (Icaritin) with a procedure that delivers chemotherapy directly to the liver (TACE) after surgery. It is for people with liver cancer who have a high chance of the cancer coming back, to see if this treatment helps prevent recurrence.
Guangzhou, GuangdongAges 18–75 - NCT07042438RecruitingPhase 2
Fecal transplant to improve CAR T therapy for lymphoma
This study tests whether a fecal transplant (transferring healthy gut bacteria) can improve outcomes for people with certain lymphomas who have taken strong antibiotics and are about to get CAR T-cell therapy (Yescarta). The goal is to see if rebuilding gut bacteria helps the treatment work better.
Duarte, CaliforniaAges 18 years+ - NCT06482073Recruiting
Genetic testing for suspected lung cancer
This study looks at genetic changes in people with suspected or high-risk lung cancer. It aims to use those results to guide more personalized treatment decisions.
Rochester, MinnesotaAges 18 years+ - NCT04743479Recruiting
AI screening for pancreatic cancer in higher-risk people
This trial uses an artificial-intelligence tool to help detect pancreatic cancer earlier and track people at higher risk. You may be asked to complete questionnaires and have imaging tests like MRI or CT to see how well the approach works.
ShanghaiAges 50–75 - NCT06632613RecruitingPhase 2
Trial of ENN0403 to prevent kidney injury after heart surgery
This study tests a new drug (ENN0403) given during heart surgery to see if it prevents acute kidney injury—a sudden drop in kidney function. The trial is for people who are already at higher risk due to their specific heart surgery and other health factors.
ShanghaiAges 18–85 - NCT06210490RecruitingPhase 2
Antibody-drug combo with radiation for HER2+ UTUC after surgery
This trial tests a combination of an antibody-drug conjugate (Disitamab Vedotin) plus radiation therapy after surgery to prevent upper tract urothelial cancer from coming back. It is for patients with HER2-positive tumors and high-risk features who cannot receive cisplatin chemo.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04297592Enrolling by invitationPhase 4
Antibiotics to prevent infection after hip or knee replacement
This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.
Iowa City, IowaAges 18–99
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Common questions
- Are there clinical trials for clinical high risk?
- Yes. Clin2 currently lists 551 recruiting clinical high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a clinical high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a clinical high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.