Clinical trials
Cognitive Decline clinical trials
Below are recruiting cognitive decline clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05822388Recruiting
Deep brain stimulation and memory changes in Parkinson’s
This study looks at whether deep brain stimulation (a surgical treatment for Parkinson’s disease) affects thinking and memory over time. It compares Parkinson’s participants to people without Parkinson’s to better understand what changes happen with treatment.
Charleston, South CarolinaAges 18 years+ - NCT05935241Recruiting
Program mPATH for sleep and activity in older adults
This trial tests a program (mPATH) to help older adults with sleep trouble by improving activity and exercise habits. It may be helpful if you have low income and want support building moderate exercise safely.
Baltimore, MarylandAges 65 years+ - NCT06052397Recruiting
Sleep and body clock markers for confusion after surgery
This trial tests whether sleep patterns and body clock signals can help predict confusion after major orthopedic surgery. You would wear a watch that tracks movement to see how your sleep relates to recovery.
Boston, MassachusettsAges 70 years+ - NCT06068582Recruiting
Keep your memory sharp and stay at work with MS
This study tests a program of physical and mental exercises designed to slow down memory and thinking problems in people with multiple sclerosis, and help them stay employed longer.
AmsterdamAges 18–67 - NCT06152614Recruiting
Healthy diet and exercise for Black adults with high blood pressure
This study tests a combined eating and exercise program for Black adults with high blood pressure. The MIND-style diet and aerobic training may help lower your blood pressure over time.
Indianapolis, IndianaAges 35–75 - NCT06292741Recruiting
Autonomic system test in people with memory loss
This study tests how the body's automatic functions (like heart rate and blood pressure) change in people with mild memory loss. It may help find early signs of nervous system problems.
Rome, LazioAges 50–85 - NCT06362707RecruitingPhase 2
Fasudil trial for early Alzheimer's disease
This trial tests a medication called fasudil to see if it can help people with early Alzheimer's disease. It is for people who have early symptoms (mild cognitive impairment or mild dementia) and have biomarker evidence of Alzheimer's in their brain.
Tromsø, NordlandAges 50–100 - NCT06375213Recruiting
Memory and thinking study for all ages
This study looks at how well people think and remember as they age. It includes healthy volunteers, people with mild memory issues, and those with dementia—both early- and late-onset.
Pathum Wan, BangkokAges 35 years+ - NCT06377254Recruiting
How activity or inactivity changes your body
This study looks at how changing your physical activity level (either becoming more or less active) affects your whole body over 6 months. It is for people aged 50–65 who are overweight and either quite sedentary or fairly active, and who are willing to change their routine.
Nottingham, NottsAges 50–65 - NCT06397469Recruiting
Digital program for attention and wellbeing in older adults
This study tests a digital program designed to help improve attention and overall wellbeing in older adults. You can take part from home using your own smartphone or tablet.
San Francisco, CaliforniaAges 60–99 - NCT06410157Recruiting
Mindfulness for heart-brain health in adults 50-70
This study tests whether a daily mindfulness practice can help older adults improve how their heart and brain work together. You will do breathing exercises at home and come to USC twice for check-ups, including blood and urine tests and an MRI.
Los Angeles, CaliforniaAges 50–70 - NCT06492109Recruiting
Blood study on sleep loss
This study looks at blood samples to understand how sleep loss affects the body. It may help find new ways to diagnose or treat sleep problems.
Hangzhou, ZhejiangAges 18–80 - NCT06648707Recruiting
Thinking and moving: a study for older adults
This study tests if combining physical and mental exercises can help prevent memory loss in older adults. If you are 65 or older and can join activities at a community center, this might be for you.
Hong KongAges 65 years+ - NCT06703320Recruiting
Virtual reality pathfinding study for stroke recovery
This study uses a virtual reality pathfinding game to see how your brain activates after a stroke. It may help doctors understand how to improve recovery.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT06703307Recruiting
Brain markers for stroke-related thinking changes
This study uses a special brain scanning technique (fNIRS) to look for markers that show how stroke affects thinking. Both people who have had a stroke and healthy volunteers can join.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT06730711Recruiting
Blood pressure and stroke-related thinking changes
This study looks at how blood pressure after a stroke might affect your thinking and memory. It uses information from your hospital stay and follow-up visits to see if there is a link.
Chongqing, Chongqing MunicipalityAges 18–90 - NCT06832761Recruiting
Lifestyle help for people with early memory concerns
This trial tests whether a lifestyle program can help people with mild memory problems (subjective cognitive decline or mild cognitive impairment) who also have at least two things that increase their risk for dementia, like high blood pressure or lack of exercise. If you're 50 or older and have these memory issues and risk factors, you may be able to join.
AmsterdamAges 50 years+ - NCT06914284Recruiting
Apathy and thinking changes in older adults with bipolar disorder
This study looks at whether apathy and certain brain markers can help predict memory and thinking problems in people over 70 with bipolar disorder. If you are 70-85, have bipolar disorder, and are currently stable (no recent mood episodes), you may be able to join.
Rennes, Ile Et VilaineAges 70–85 - NCT06960096Recruiting
Cognitive decline after deep brain stimulation: an MRI study
This study uses MRI scans to see how deep brain stimulation (DBS) affects thinking and memory in people with Parkinson's disease. It may help researchers understand why some people experience cognitive changes after DBS surgery.
Charleston, South CarolinaAges 18 years+ - NCT07036328Recruiting
Magnetic brain stimulation to slow memory loss in Alzheimer's
This study tests whether a noninvasive magnetic brain stimulation treatment can slow down cognitive decline in people with early Alzheimer's disease. You'll receive daily sessions over several weeks, and the goal is to see if it helps preserve memory and thinking skills.
AmsterdamAges 50–85 - NCT07044596Recruiting
Non-invasive brain stimulation to slow cognitive decline
This study tests whether a gentle, non-invasive electrical stimulation can help slow memory loss or thinking problems. It is looking for healthy volunteers and people who have had a mild traumatic brain injury within the past year.
Madison, WisconsinAges 20–85 - NCT07151365Recruiting
Plant-based diets and healthy aging study
This study looks at how a plant-based diet might help people age in a healthy way. It is for adults 40 and older who are part of the Tzu Chi Foundation and are joining a health checkup program.
Dalin, ChiayiAges 40 years+ - NCT07217912RecruitingPhase 2
Study of daridorexant to prevent confusion after heart surgery
This trial tests whether a sleep medication called daridorexant can help prevent delirium (sudden confusion) in older adults after heart surgery. You must be 60 or older and having a specific type of heart operation.
Rochester, New YorkAges 60 years+ - NCT07324330Recruiting
Slowing cognitive decline with exercise in iRBD
This study tests if increasing physical activity can help slow down cognitive (thinking) decline in people with iRBD, a sleep disorder that often leads to Parkinson's or dementia. You'll use a smartphone and a FitBit to track your activity and receive coaching.
Bonn, North Rhine West-FaliaAges 50–80
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Common questions
- Are there clinical trials for cognitive decline?
- Yes. Clin2 currently lists 181 recruiting cognitive decline studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive decline trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive decline trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.