Clinical trials
Colonic Neoplasms Malignant clinical trials
Below are recruiting colonic neoplasms malignant clinical trials, each written for real people, not researchers. We’re tracking 40 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06885697RecruitingPhase 1
CAR T cells targeting mesothelin for solid tumors
This study tests a new treatment called CAR T cells that target a protein called mesothelin found on certain cancer cells. The CAR T cells are made from your own immune cells and may help shrink tumors that have not responded to other therapies.
Bethesda, MarylandAges 18–120 - NCT07594626RecruitingPhase 1/Phase 2
BMS-986504 and Pemetrexed for Advanced Tumors With MTAP Loss
This trial tests a new drug (BMS-986504) combined with an existing chemotherapy (pemetrexed) for advanced solid cancers that have a specific genetic change called MTAP deletion. The trial aims to see if this combination can slow or stop tumor growth in patients whose cancer has progressed despite prior treatment.
Chicago, IllinoisAges 18 years+ - NCT06338332Recruiting
Stent before surgery for right-sided colon blockage from cancer
This trial tests whether placing a stent first to relieve a blockage in the right side of the colon improves outcomes before surgery for colon cancer. It aims to help patients who come to the hospital with a blocked colon due to cancer.
Breda, North BrabantAges 18 years+ - NCT06121089Recruiting
Surgery for early-stage cecal cancer
This trial is testing different surgical approaches for people with cecal cancer that hasn't spread. The goal is to find the best treatment option for patients whose tumors are at a stage where surgery can be curative.
MoscowAges 18 years+ - NCT06349642Recruiting
Testing a live tumor test for immune therapy response
This trial uses a special test on live tumor samples to see if it can predict how well immune checkpoint inhibitors (a type of immunotherapy) will work for different cancers. It may help doctors choose the best treatment for you.
Phoenix, ArizonaAges 18 years+ - NCT06652672Recruiting
Sentinel Node and Organ-Sparing Surgery for Early Colon Cancer
This trial tests a less invasive surgery approach for early-stage colon cancer. It uses a special dye to find and remove only the first lymph node (sentinel node) while removing just the part of the colon with the tumor, possibly avoiding a bigger surgery.
AmersfoortAges 18 years+ - NCT06989814Recruiting
Liquid biopsy test for Lynch syndrome cancer patients
This trial tests a simple blood test to measure tumor DNA in people with Lynch syndrome who have been newly diagnosed with cancer but haven't started treatment yet. It aims to see if this test can help monitor the cancer.
Leiden, South HollandAges 18 years+ - NCT03819296RecruitingPhase 1
Fecal transplant to treat cancer immunotherapy bowel side effects
This early-phase study tests whether changing your gut bacteria with a fecal transplant can improve diarrhea or colitis caused by cancer immunotherapy. It may help people whose symptoms have not fully settled with standard treatments like steroids and other immune-blocking medicines.
Houston, TexasAges 18 years+ - NCT06575127RecruitingPhase 2
Three-drug chemo plus targeted therapy for advanced colorectal cancer
This trial tests a combination of three chemotherapy drugs plus a targeted therapy as a first treatment for advanced colorectal cancer. The goal is to see if this strong drug mix can shrink tumors better than standard approaches.
Cairo, Cairo GovernorateAges 18–65 - NCT06640166RecruitingPhase 2
Encorafenib + Cetuximab with FOLFIRI after progression
This trial tests adding a new chemotherapy regimen (FOLFIRI) to the combination of Encorafenib and Cetuximab for people with a specific type of advanced colorectal cancer that has started growing again after initial treatment with Encorafenib and Cetuximab. The goal is to see if the new combination can help control the cancer longer.
MilanAges 18 years+ - NCT04678648RecruitingPhase 1
Testing RSC-1255 in advanced cancers with RAS changes
This early study (Phase 1) tests a new drug, RSC-1255, in people with advanced or metastatic cancers that have RAS mutations. It’s mainly focused on whether the treatment can be given safely and at what dose, and to see if it may shrink tumors.
Los Angeles, CaliforniaAges 18 years+ - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80 - NCT07154173Recruiting
Gut bacteria study in metastatic colorectal cancer
This study looks at gut bacteria in people with colorectal cancer that has spread (metastatic). It aims to find patterns in the bacteria that may help doctors choose better treatments.
Guangzhou, GuangdongAges 18–75 - NCT06050447Recruiting
Study on treatment results for colorectal cancer
This study looks at factors that affect outcomes in people with colorectal cancer who have surgery as their main treatment. It aims to help doctors understand how to improve care.
Kaliningrad, Kaliningrad OblastAges 18 years+ - NCT06500377Recruiting
Comparing meditation types for relaxation in cancer survivors
This study compares four different meditation practices to see which one helps cancer survivors relax best. If you are a cancer survivor who has not had chemotherapy or radiation, you may be able to join.
Duarte, CaliforniaAges 18 years+ - NCT06192875Recruiting
Blood test for early cancer detection: the NOMAD study
This study is testing a new blood test to look for early signs of cancer in people without a past cancer diagnosis. You would give blood, urine, and saliva samples to help researchers see if the test works well.
Rochester, MinnesotaAges 18 years+ - NCT06567782RecruitingPhase 2
Immunotherapy plus chemotherapy vs. chemotherapy alone for stage 3 colon cancer
This trial tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (CAPEOX) is more effective than chemotherapy alone for people with a specific type of colon cancer (MMRp/MSS) that has not spread. It is given before surgery to shrink the tumor.
AalstAges 18 years+ - NCT05914389RecruitingPhase 2
Immunotherapy plus chemotherapy before surgery for colon cancer
This Phase 2 trial studies giving chemotherapy plus immune therapy before surgery for certain colon cancers that do not have mismatch repair defects (MSS/pMMR). The goal is to shrink and control the tumor and improve outcomes compared with standard approaches.
Hangzhou, ZhejiangAges 18–75 - NCT06051695RecruitingPhase 1/Phase 2
CAR T cell therapy for mesothelin-positive solid tumors
This trial tests a new type of immune cell therapy (CAR T-cells) designed to target cancer cells that have a protein called mesothelin but have lost a marker that lets them hide from the immune system. It's for people with advanced solid tumors who have already tried standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT07172191Enrolling by invitation
Fecal transplant for adults with blood cancer and infections
This trial tests whether transplanting healthy donor bacteria (fecal microbiota) into the gut can help adults with blood cancers who have stubborn infections, C. diff, or complications after stem cell transplant. It may reduce dangerous germs and improve gut health.
Budapest, BudapestAges Any age - NCT07314996Recruiting
Laparoscopic vs. open surgery for colon cancer with belly fat
This trial compares laparoscopy (minimally invasive) and open surgery for treating colon cancer in people with extra belly fat around internal organs (visceral obesity). The goal is to see which approach gives better recovery and outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT02886104Recruiting
Surgery versus local ablation for certain liver metastases
This trial compares two ways to treat colorectal cancer that has spread to the liver: removing liver tumors with surgery versus destroying them in place with local ablation. It may help doctors learn which approach works best for people whose disease can be fully treated and who have enough healthy liver left.
Guangzhou, GuangdongAges 18–80 - NCT07026422RecruitingPhase 2
Combination immunotherapy with chemoradiation for high-risk rectal cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy and radiation before surgery for people with a specific type of high-risk rectal cancer. The goal is to see if adding these drugs can improve treatment results.
Jinan, ShandongAges 18–75 - NCT05588453RecruitingPhase 1/Phase 2
Immunotherapy and temozolomide for melanoma brain metastases
This early-phase study tests an immune cell treatment (natural killer cells) plus temozolomide to treat melanoma that has spread to the brain. It’s for people whose brain spots are getting worse and who are not good candidates for certain types of brain radiation.
Columbus, OhioAges 18 years+
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Common questions
- Are there clinical trials for colonic neoplasms malignant?
- Yes. Clin2 currently lists 40 recruiting colonic neoplasms malignant studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colonic neoplasms malignant trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colonic neoplasms malignant trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.