Clinical trials
Colorectal Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting colorectal cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,511 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05891561RecruitingPhase 2
Short antibody treatment after surgery for early HER2+ breast cancer
This Phase 2 study tests a shorter schedule of trastuzumab and pertuzumab combined with chemotherapy (taxanes) to reduce breast cancer coming back after surgery. It mainly helps people with early-stage, HER2-positive breast cancer that has not spread, by testing whether a shorter plan still works well and is tolerable.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06709326Recruiting
Collecting blood cells to study prostate cancer
This study uses a blood filtering procedure (apheresis) to collect prostate cancer cells from your blood for detailed analysis. It may help researchers understand why some prostate cancers spread, which could lead to better treatments. There are three groups: men with metastatic prostate cancer, men with PSA relapse after prostatectomy, and healthy volunteers.
Umeå, Norrlands University HospitalAges 18–81 - NCT07605611Recruiting
Somatostatin and Diet vs. Stoma After Rectal Cancer Surgery
This trial tests whether using a medication called somatostatin plus a clear liquid diet can safely prevent serious complications after surgery to remove rectal cancer, without needing a temporary opening in the abdomen (stoma). You'll be randomly assigned to receive either somatostatin with diet changes or a stoma, depending on your individual risk factors.
Ezhou, HubeiAges 18–75 - NCT07607873Recruiting
Transplant vs surgery after chemo for liver-only colorectal cancer
This trial compares liver transplant versus liver surgery for people whose colorectal cancer has spread only to the liver and cannot be removed initially. You would first receive chemotherapy to shrink the tumors, and if they become removable, you may be randomly assigned to have a liver transplant or standard liver surgery.
MilanAges 18 years+ - NCT07611825RecruitingPhase 2
Gut Bacteria Treatment for Advanced Kidney Cancer Resistant to Immunotherapy
This study tests whether modifying your gut bacteria can help immunotherapy work again in advanced kidney cancer that has stopped responding to initial immune-checkpoint inhibitor treatment. Researchers will give you a special bacterial preparation along with a new immunotherapy drug to see if this combination can slow or shrink your cancer.
Nanjing, JiangsuAges 18–90 - NCT06711055Recruiting
Taxane plus targeted therapy for early HER2-positive breast cancer
This trial tests a taxane chemotherapy combined with a targeted therapy for women with early-stage, HER2-positive breast cancer that has not spread to lymph nodes. It aims to provide a tailored treatment based on tumor size and risk factors.
Beijing, Beijing MunicipalityAges Any age - NCT06711068Recruiting
Chemotherapy plus targeted therapy for HER2+ early breast cancer
This trial tests whether adding targeted therapy to chemotherapy after surgery can help prevent HER2-positive early breast cancer from coming back. It is for patients whose cancer has not spread to lymph nodes and who have certain tumor sizes and features.
Beijing, Beijing MunicipalityAges Any age - NCT06302062RecruitingPhase 1
Using lymph node T cells for advanced solid tumors
This trial tests a new treatment using T cells taken from your lymph nodes to fight advanced solid tumors that have not responded to standard therapies. The goal is to see if this approach can help shrink tumors or slow their growth.
Guangzhou, GaungdongAges 18–75 - NCT05916040Recruiting
MRI-guided treatment for locally advanced rectal cancer
This trial studies a total “before-surgery” treatment plan for locally advanced rectal cancer, using MRI (a detailed scan) to help guide radiation. It may help patients by aiming to shrink the tumor and improve the chance of successful surgery.
Jette, Brussels CapitalAges 18 years+ - NCT05214937Recruiting
Help to reduce sitting time in prostate cancer survivors
This study tests an intervention to help prostate cancer survivors sit less and move more. It may help improve daily activity and reduce long periods of inactivity.
Toronto, OntarioAges 18 years+ - NCT07596693RecruitingPhase 1
KXV01 injection for advanced solid tumors
This early-stage trial tests KXV01, a personalized cancer treatment made from your own immune cells, for advanced solid tumors that have not responded to standard treatment. The goal is to see if it can help control your cancer and learn about its safety.
ShanghaiAges 18–70 - NCT07601334RecruitingPhase 1
Testing HF50 safety in advanced solid tumors
This Phase 1 trial tests a new drug called HF50 in people with advanced cancers that have spread or cannot be surgically removed. The goal is to see if HF50 is safe and whether it helps shrink tumors in patients whose cancer has not responded to standard treatments.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07600554RecruitingPhase 1
Imaging Study for Prostate Cancer Detection
This research study tests a new imaging scan (called 68Ga-OncoACP3-PET/CT) to help find prostate cancer and see where it may have spread. The scan uses a radioactive tracer to help doctors visualize cancer cells and decide on the best treatment options.
Bergamo, BergamoAges 18 years+ - NCT07597083Recruiting
Pelvic Floor Training for Sexual Function After Cervical Cancer
This study tests whether biofeedback-assisted pelvic floor rehabilitation—a guided exercise program with real-time feedback—can improve sexual function in women who experienced sexual difficulties after radiation treatment for cervical cancer. The goal is to help restore comfort and satisfaction in intimate life.
Banī SuwayfAges 30–60 - NCT07600957Recruiting
Polarized Light Therapy to Ease Radiation Skin Damage
This trial tests whether a special type of light therapy can reduce skin damage and irritation that happens during radiation treatment for breast cancer. If it works, it could help patients feel more comfortable during and after their radiation therapy.
Banī SuwayfAges 35–55 - NCT05606523Recruiting
Test gut bacteria treatment for weight loss in pancreatic cancer
This study looks at how changing the gut microbiome (gut bacteria) may help people with pancreatic cancer regain strength and slow or reverse cancer-related weight loss (cachexia). It also studies gut bacteria differences in people with pancreatic cancer who are losing weight versus those whose weight is stable, and in healthy volunteers.
GenevaAges 18 years+ - NCT07589569RecruitingPhase 2
HRS-7058 for Advanced Pancreatic Cancer Treatment
This study tests a new drug called HRS-7058 in patients with pancreatic cancer that has spread or cannot be removed by surgery. You may qualify if your cancer has already been treated with at least one prior therapy and you have measurable disease on imaging.
Nanjing, JiangsuAges 18–75 - NCT07587957Recruiting
Exercise and Brain Stimulation for Breast Cancer Survivors
This study tests whether combining exercise with a noninvasive brain-stimulation technique (tiny electrical pulses on the scalp) can help improve thinking and memory problems that some breast cancer survivors experience after treatment. Researchers want to see if this combination is practical and safe to use.
Boca Raton, FloridaAges 18 years+ - NCT07587268Recruiting
Understanding Your Appendiceal Cancer Through Genetic Testing
This research study uses genetic and molecular testing on archived tumor samples to better understand appendiceal cancer and predict how it may progress. The goal is to help doctors personalize treatment plans based on the specific characteristics of your cancer.
Durate, CaliforniaAges 18 years+ - NCT06426680RecruitingPhase 1
Study of ILB-3101 for advanced solid tumors
This study tests a new drug, ILB-3101, for people with advanced solid tumors that have not responded to standard treatments. It aims to see if the drug is safe and how well it works.
ShanghaiAges 18–80 - NCT07585838Enrolling by invitation
Hope-Focused Counseling During Cancer Radiation Treatment
This study tests whether motivational interviews—supportive conversations focused on hope and positive thinking—help cancer patients cope better while receiving radiation therapy. The goal is to improve emotional well-being and treatment outcomes for newly diagnosed patients.
Bartın, BartınAges 18–65 - NCT07578519RecruitingPhase 2
Personalized Radiation Therapy for Intermediate to High-Risk Prostate Cancer
This trial tests a new type of radiation therapy that is customized for each patient's prostate cancer. The radiation targets the tumor more precisely, which may help reduce side effects while treating the cancer effectively.
Lethbridge, AlbertaAges 18 years+ - NCT06722612Recruiting
Chemo plus targeted therapy for high-risk HER2+ early breast cancer
This trial tests whether combining chemotherapy with targeted therapy works better for women with high-risk, HER2 positive early breast cancer that hasn't spread to lymph nodes. If you've had surgery and your tumor fits certain high-risk features, you may be eligible to join.
Beijing, Beijing MunicipalityAges Any age - NCT06418594RecruitingPhase 2
Drug combo for HER2-negative breast cancer brain metastasis
This trial tests a combination of two drugs (adebrelimab and apatinib) plus chemotherapy for women with HER2-negative breast cancer that has spread to the brain. It aims to see if this treatment can help shrink or control brain tumors.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,511 recruiting colorectal cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced Colorectal Cancer
- Lung Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- Metastatic Colorectal Cancer
- Locally Advanced Rectal Cancer
- Metastatic Colorectal Cancer (CRC)
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.