Clinical trials
Critically Ill Patients clinical trials
Below are recruiting critically ill patients clinical trials, each written for real people, not researchers. We’re tracking 317 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07496255Recruiting
Virtual reality for memory help after ICU confusion
This trial tests whether using virtual reality (VR) can help older adults recover their thinking and memory after a serious illness and confusion in the ICU. You may be eligible if you are 50 or older, spent time on a breathing machine, and had delirium in the ICU.
Indianapolis, IndianaAges 50 years+ - NCT06259565RecruitingPhase 3
Breathing mask sedation trial for agitated adults
This trial tests whether adding a sedative called dexmedetomidine to non-invasive ventilation (a breathing mask) helps adults who are agitated or uncomfortable while on the mask. It aims to improve comfort and avoid the need for a breathing tube.
Surrey, British ColumbiaAges 18 years+ - NCT07522580Recruiting
Heart Fluid Response Monitoring in Critically Ill Children
This study tests a simple, non-invasive device that measures how well a child's heart responds when doctors give extra fluids during intensive care. It helps doctors decide if more fluids will actually help the child feel better.
Le Plessis-Robinson, FranceAges birth–8 years - NCT06934876Recruiting
Comparing two CO2 detectors during breathing tube placement in critically ill adults
This study compares two ways of checking that a breathing tube is placed correctly in seriously ill adults: one uses a device that shows a waveform on a screen, and the other uses a color-changing test. It may help doctors choose the best method for patients in the emergency room or ICU.
Chicago, IllinoisAges 18 years+ - NCT07329530Recruiting
Muscle and metabolism study in ICU survivors
This study looks at muscle and metabolism changes in people who have been in the ICU for at least 7 days after major abdominal surgery. It aims to understand how recovery affects the body.
LiègeAges 18 years+ - NCT06669494Enrolling by invitation
Study on ICU muscle weakness detection and monitoring
This study aims to find better ways to detect and track muscle weakness that can happen during an ICU stay. If you or your loved one is in the ICU, this research could help improve early diagnosis and care.
Seoul, SeoulAges 18 years+ - NCT06584604Recruiting
Calibrating esophageal balloon for breathing machine patients
This trial is testing how to calibrate an esophageal balloon (a thin tube that measures pressure in your chest) for people on a breathing machine. If you are already sedated and have this tube in place, participating may help doctors get more accurate readings to improve your breathing support.
Leiden, South HollandAges 18 years+ - NCT07048951Recruiting
Memory and awareness after ICU: understanding moments of disconnect
This trial studies episodes of lost or altered consciousness that some people experience after a long stay in the ICU. It aims to understand how these episodes affect memory and recovery.
Liège, LiègeAges 18 years+ - NCT07177183Recruiting
Low creatinine as a sign of longer breathing tube use
This study looks at whether low blood creatinine levels can help predict which patients will need a breathing machine for a long time or have trouble coming off it. If you are under 18 and in a post-ICU care unit, you may be able to join.
BrnoAges 18 years+ - NCT07300306Recruiting
Studying a new sepsis score in Turkish ICUs
This trial tests a new scoring system called SOFA-2 to better predict death and identify sepsis in adults staying in intensive care units (ICUs) in Turkey.
IstanbulAges 18 years+ - NCT07722897Recruiting
Monitoring brain activity during emergency intubation
This study tests whether monitoring brain activity (using a sensor on the forehead) during emergency intubation helps prevent unstable blood pressure or heart rate. It is for adults who need a breathing tube placed quickly in the emergency room.
AntalyaAges 18 years+ - NCT04110613Recruiting
Early feeding after PEG tube placement in ICU patients
This trial tests whether starting tube feeds soon after a PEG tube is placed is safe and helpful for mechanically ventilated ICU patients. PEG is a feeding tube placed through the belly, and early feeding may support recovery if your stomach can handle it.
Roanoke, VirginiaAges 18–100 - NCT04201704Recruiting
Less IV fluids for children after trauma
This trial studies whether giving children less fluid through a vein after serious injury helps them recover safely. Children are enrolled soon after arrival to the ICU so the team can compare outcomes between different fluid amounts.
Buffalo, New YorkAges 6 months–15 years - NCT04530760Recruiting
Study of breathing problems in people with liver scarring on a ventilator
This study looks at whether people with cirrhosis who are on a breathing machine have increased pressure in the belly and small unnoticed breathing mist (microaspiration). It may help doctors better monitor and prevent breathing complications while patients are being mechanically ventilated.
LilleAges 18–99 - NCT04541862Recruiting
ICU patient information database for adults
This trial collects and studies health information from people who are critically ill and admitted to an intensive care unit. It may help doctors learn how to better care for ICU patients in the future.
TaipeiAges 20 years+ - NCT04705896RecruitingPhase 4
Albumin for kidney recovery after ICU kidney injury
This trial tests whether giving albumin (a blood protein through an IV) can improve recovery after acute kidney injury in people who are in the ICU and need kidney support treatment. It mainly aims to help the kidneys bounce back better after this serious illness.
Calgary, AlbertaAges 18 years+ - NCT04801589RecruitingPhase 3
Guided sedation for children on a breathing machine
This study tests a “goal-directed” approach to sedation (giving the right amount based on target goals) for children who need a breathing machine in the pediatric ICU. The goal is to reduce brain and recovery side effects while keeping children comfortable and safe.
Nashville, TennesseeAges 10 months–11 years - NCT05014581RecruitingPhase 3
Testing vasopressors to prevent low blood pressure during intubation
This trial studies whether using blood-pressure support medicines (vasopressors) during breathing tube placement (intubation) can prevent dangerous drops in circulation (“cardiovascular collapse”). It may help patients stay stable during and after intubation, especially in critical illness.
NantesAges 18–90 - NCT05044403Recruiting
Hemoperfusion for severe sepsis causing multiple organ failure
This study tests whether a blood-filter treatment called hemoperfusion can help critically ill people with sepsis that is not responding to standard shock treatment and is affecting multiple organs. It aims to improve recovery when infections are controlled and inflammation markers are very high.
Castellon, CastellónAges 18–80 - NCT05191381Recruiting
Immune treatment using exosome therapy for severe COVID-19
This trial tests whether immune-supporting treatment made from exosomes can help people with critically severe COVID-19 and lung damage. If you qualify, you may receive this therapy as part of the study to see if it improves outcomes.
UlmAges 18–90 - NCT05246098Recruiting
Rehabilitation program study for young and adult ICU COVID/respiratory survivors
This study looks at whether a rehabilitation approach improves recovery outcomes for people who survived COVID-19 or a serious breathing infection and needed ICU/PICU care. It may help those still dealing with physical or functional problems after their critical illness.
Calgary, AlbertaAges Any age - NCT05440851Recruiting
Testing different treatments for severe breathing failure in ICU
This platform trial studies which treatment works best for adults with sudden, severe breathing failure needing oxygen or a breathing machine in the ICU. It may help patients by matching them to the most appropriate treatment strategy and tracking outcomes to improve care.
Tucson, ArizonaAges 18 years+ - NCT05616130Recruiting
Study of abnormal blood immune activation after trauma or elective hip surgery
This study looks at how the body’s blood-related immune system “switches on” in unusual ways after a major injury or elective hip repair. The researchers hope this helps them understand who is at risk for complications and why, by measuring changes in your blood around the time of surgery or hospital treatment.
Gainesville, FloridaAges 18–100 - NCT05634135Recruiting
Testing breathing and blood-flow patterns in long-term ventilated ICU patients
This study looks at how well air moves through the lungs and how blood flows in different types of patients who have been on a breathing machine for a long time. It may help clinicians better understand these patterns during “weaning” (trying to come off the machine), which could improve care plans.
TaipeiAges 20 years+
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Common questions
- Are there clinical trials for critically ill patients?
- Yes. Clin2 currently lists 317 recruiting critically ill patients studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critically ill patients trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critically ill patients trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.