Clinical trials
Critically Ill Patients clinical trials
Below are recruiting critically ill patients clinical trials, each written for real people, not researchers. We’re tracking 295 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05044403Recruiting
Hemoperfusion for severe sepsis causing multiple organ failure
This study tests whether a blood-filter treatment called hemoperfusion can help critically ill people with sepsis that is not responding to standard shock treatment and is affecting multiple organs. It aims to improve recovery when infections are controlled and inflammation markers are very high.
Castellon, CastellónAges 18–80 - NCT06934876Recruiting
Comparing two CO2 detectors during breathing tube placement in critically ill adults
This study compares two ways of checking that a breathing tube is placed correctly in seriously ill adults: one uses a device that shows a waveform on a screen, and the other uses a color-changing test. It may help doctors choose the best method for patients in the emergency room or ICU.
Chicago, IllinoisAges 18 years+ - NCT06574672Recruiting
Palliative care in the medical ICU
This study tests whether adding palliative care (comfort and support care) to usual MICU treatment helps patients and families. It takes place in the medical intensive care unit.
St Louis, MissouriAges 18 years+ - NCT06692400Recruiting
Suctioning, pain, and blood markers in intubated patients
This study looks at how routine suctioning of the breathing tube affects pain levels and certain substances in the blood in adults who are on a breathing machine for serious infections like flu, pneumonia, COVID, or sepsis. It may help doctors better understand and manage your comfort during this procedure.
Loma Linda, CaliforniaAges 18 years+ - NCT06669494Enrolling by invitation
Study on ICU muscle weakness detection and monitoring
This study aims to find better ways to detect and track muscle weakness that can happen during an ICU stay. If you or your loved one is in the ICU, this research could help improve early diagnosis and care.
Seoul, SeoulAges 18 years+ - NCT06606119Recruiting
Brain, bone marrow, and gut study after major injury
This study is looking at how the brain, bone marrow, and gut interact after a severe injury. It may help doctors understand how to better treat trauma patients.
Gainesville, FloridaAges 18–100 - NCT05985525Recruiting
Monitoring blood flow in ICU patients with severe infection or shock
This study monitors tiny blood vessels under the tongue using a non-invasive device to see how well blood flows in ICU patients on a breathing machine. Researchers hope to improve care for patients with serious infections or shock.
Winnipeg, ManitobaAges 18 years+ - NCT06588556Recruiting
Improving Care for Older Adults in the ICU
This study tests a program to improve communication and support for older adults in the ICU and their families. It may help families feel more supported during a serious illness.
Birmingham, AlabamaAges 18 years+ - NCT02182180Recruiting
SC2i tissue and data collection for people needing urgent care
This study collects small samples of tissue and body fluids and related health data from people who need surgery or treatment in an emergency or critical care setting. The goal is to build a resource researchers can use to better understand illness and improve care.
Atlanta, GeorgiaAges 18 years+ - NCT06526533RecruitingPhase 3
Red blood cell transfusion thresholds for ECMO patients
This trial is testing whether a higher or lower threshold for red blood cell transfusions is better for people on ECMO (a heart-lung machine). It aims to find the safest way to manage transfusions during ECMO treatment.
Camperdown, New South WalesAges Any age - NCT06481644Recruiting
Study of kids in Asian pediatric ICUs
This study looks at children admitted to pediatric intensive care units (ICUs) in Asia to understand their health patterns and outcomes. It may help improve care for future patients.
SingaporeAges Any age - NCT06259565RecruitingPhase 3
Breathing mask sedation trial for agitated adults
This trial tests whether adding a sedative called dexmedetomidine to non-invasive ventilation (a breathing mask) helps adults who are agitated or uncomfortable while on the mask. It aims to improve comfort and avoid the need for a breathing tube.
Surrey, British ColumbiaAges 18 years+ - NCT06193980Recruiting
ICU recovery exercise test study
This trial looks at how well your heart and lungs work together after a long stay in the ICU on a breathing machine. It uses a simple exercise test to check your recovery after leaving the hospital.
Winnipeg, ManitobaAges 18 years+ - NCT06184945Recruiting
Behavioral and staffing strategies in the ICU
This study tests different ways of organizing care and supporting patients in the intensive care unit (ICU) to see if they can improve recovery and well-being. It focuses on adults who need a breathing tube and are in the ICU for at least a day.
Iowa City, IowaAges 19 years+ - NCT06150326Recruiting
Medical honey for wound treatment in intensive care
This trial tests whether medical honey can help heal wounds like bedsores, cuts, or surgical openings in intensive care patients. If you have a fresh wound that meets the size requirements, you may be able to join.
AngersAges 18 years+ - NCT06117345Enrolling by invitation
PICU Journal for Parents and Caregivers
This study tests a journal to help parents and caregivers stay involved while their child is in the pediatric intensive care unit (PICU). It aims to see if the journal improves communication and engagement.
Nashville, TennesseeAges 18 years+ - NCT05906472Recruiting
Feeding through a tube after tracheostomy in the ICU
This study tests a specific way of continuing tube feeding for people who need a tracheostomy after being on a breathing tube in the ICU. The goal is to see if this feeding approach is safe and beneficial for recovery.
Danbury, ConnecticutAges 18 years+ - NCT02804438Recruiting
Pupil measurement checks in neurocritical care patients
This study collects normal (baseline) results from a handheld eye pupil camera (a pupillometer) used during routine neuro–intensive care checks. It may help clinicians better interpret these eye measurements in future patients.
Dallas, TexasAges Any age - NCT02539407Recruiting
Study drug levels in critically ill children
This trial measures how anti-infective medicines move through a child’s body while they are in the hospital or during follow-up. The goal is to better understand dosing and drug exposure in critically ill children.
ParisAges 1 day–18 years - NCT05616130Recruiting
Study of abnormal blood immune activation after trauma or elective hip surgery
This study looks at how the body’s blood-related immune system “switches on” in unusual ways after a major injury or elective hip repair. The researchers hope this helps them understand who is at risk for complications and why, by measuring changes in your blood around the time of surgery or hospital treatment.
Gainesville, FloridaAges 18–100 - NCT05440851Recruiting
Testing different treatments for severe breathing failure in ICU
This platform trial studies which treatment works best for adults with sudden, severe breathing failure needing oxygen or a breathing machine in the ICU. It may help patients by matching them to the most appropriate treatment strategy and tracking outcomes to improve care.
Tucson, ArizonaAges 18 years+ - NCT05409573Recruiting
Check oxygen monitoring during pre-intubation in the ICU
This study tests whether a specific oxygen level monitor (end-tidal oxygen, or EtO2) can be used during “preoxygenation” before breathing tube placement. It may help clinicians intubate more safely for people who urgently need a breathing tube due to serious breathing failure.
OrléansAges 18 years+ - NCT05279547Recruiting
Bed-cycle exercise study to test muscle oxygen during ICU care
This trial tests whether brief “interval” bed-cycling changes how well your leg muscles use oxygen compared with steady cycling. It’s meant for carefully selected ICU patients who can safely do active cycling while on ventilator support.
LeuvenAges 18 years+ - NCT04530760Recruiting
Study of breathing problems in people with liver scarring on a ventilator
This study looks at whether people with cirrhosis who are on a breathing machine have increased pressure in the belly and small unnoticed breathing mist (microaspiration). It may help doctors better monitor and prevent breathing complications while patients are being mechanically ventilated.
LilleAges 18–99
Hear when a new Critically Ill Patients trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for critically ill patients?
- Yes. Clin2 currently lists 295 recruiting critically ill patients studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critically ill patients trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critically ill patients trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.