Clinical trials
Dementia clinical trials
Below are recruiting dementia clinical trials, each written for real people, not researchers. We’re tracking 488 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05826457Enrolling by invitation
Study for early RBD as a possible Parkinson’s risk
This study looks at people with REM sleep behavior disorder (RBD), confirmed by a sleep test, who may be in the early “prodromal” stage before Parkinson’s or related diseases. It also enrolls healthy controls to compare results from brain and body testing to better understand who is at risk.
Los Angeles, CaliforniaAges 18 years+ - NCT05649800Recruiting
Study brain and blood-vessel changes in older adults after stroke
This study looks at how blood flow in the brain and related brain processes change after stroke, especially when someone also has conditions like dementia, depression, or delirium. It may help researchers understand what drives these problems and how they connect.
Leicester, LeicestershireAges 65 years+ - NCT05741853Recruiting
Speech therapy study for bilingual people with primary progressive aphasia
This study looks at how well speech-language therapy works in bilingual people with primary progressive aphasia, a condition that gradually affects language. It also tests whether different language skills (Spanish/Catalan or Spanish/English) affect response to treatment.
Austin, TexasAges 40 years+ - NCT05704309Enrolling by invitation
Study of diabetes prevention participants using brain scans
This study looks at how people who previously took part in a diabetes prevention program are doing over time, including brain health using MRI scans for some participants. It may help researchers understand who is at higher risk for memory and thinking problems and why.
Phoenix, ArizonaAges Any age - NCT05661084Recruiting
Non-surgery brain stimulation for dementia thinking and movement
This study tests whether a non-invasive brain stimulation device (tES) can improve thinking and movement problems in people with dementia. You (and your caregiver, if needed) will be asked to follow the study plan and attend visits so researchers can measure results and safety.
Boston, MassachusettsAges 55 years+ - NCT05643144Recruiting
Shared decisions for dementia and diabetes care
This study tests a program that helps people with both memory problems (like dementia or mild cognitive impairment) and diabetes, along with their caregivers, make better care decisions together. It uses a special device to track blood sugar without fingersticks.
Indianapolis, IndianaAges 65 years+ - NCT05592366Recruiting
Testing a hospital tool for unpaid dementia caregivers
This study is testing a care-partner support tool for people who provide unpaid care to a hospitalized adult loved one or partner with dementia-related needs. It may help caregivers and hospitals communicate and coordinate better during a hospital stay.
Madison, WisconsinAges 18 years+ - NCT05592678Recruiting
Study brain and memory test changes in Alzheimer’s or mild issues
This study looks at how well people with Alzheimer’s disease (AD) or mild cognitive impairment (MCI) perform on standardized memory/brain tests. It may help researchers understand changes over time, and whether certain types of brain signals or test results track with the condition.
San Antonio, TexasAges 65–100 - NCT05582161RecruitingPhase 2
Test drug target for Alzheimer’s or memory loss
This Phase 2 study looks at how well a medicine that targets DAO (an enzyme in the body) helps people with Alzheimer’s disease or mild cognitive impairment. You may be considered if your memory symptoms are mild to moderate and you meet specific brain-function and symptom scoring rules.
Kaohsiung CityAges 50–90 - NCT05561205Recruiting
Brain stimulation to treat persistent apathy
This trial tests a noninvasive brain stimulation treatment (called rTMS) to help people who have had ongoing apathy (lack of motivation/interest) for at least a month. You might benefit if your apathy is persistent, your other symptoms are stable, and you meet the safety and medication rules.
Toronto, OntarioAges Any age - NCT04171323Recruiting
Active mind training to improve thinking and delay dementia
This study tests an “active mind” computer-based program to help improve thinking skills and possibly slow the process toward dementia. You may be randomly assigned to different program options to see which approach works best for your goals.
San Francisco, CaliforniaAges 55–89 - NCT05326750Recruiting
Brain stimulation to help diagnose and manage memory conditions
This trial studies a non-invasive brain-stimulation approach to help doctors assess and manage certain brain-related conditions. You might benefit by contributing to better diagnostic tools and treatment planning for memory and thinking problems.
KuopioAges 18 years+ - NCT05288842Recruiting
Study spinal fluid and brain changes in dementia types
This study looks at spinal fluid and MRI results in people with Alzheimer’s disease, frontotemporal dementia, or normal thinking (controls). It aims to understand differences in brain-related cells and measure what might help explain or track these conditions.
LilleAges 40–85 - NCT05234866Recruiting
Test for “paradoxical lucidity” in severe late-stage dementia
This trial studies whether “paradoxical lucidity” can happen in people with very advanced dementia. It may help doctors understand changes in awareness in late-stage illness and improve how care is provided.
New York, New YorkAges 18 years+ - NCT05138588Recruiting
rTMS for thinking ups and downs in Lewy body dementia
This study tests whether repeat rTMS sessions can improve thinking “fluctuations” (noticeable ups and downs) in people with Lewy body dementia. It’s a proof-of-concept trial, meaning it’s mainly to see if the approach is feasible and potentially helpful.
StrasbourgAges 45 years+ - NCT04997642Recruiting
Parkinson’s patient database for memory and movement tracking
This study builds a research database of people who receive care for Parkinson’s disease, including those with mild memory problems or dementia. It aims to collect consistent information that researchers can use to better understand Parkinson’s and related thinking changes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04961450Enrolling by invitation
Study tracking brain illness markers in motor neuron and frontotemporal disease
This study looks for “biomarkers” (measurable signs in blood or other samples) in people with motor neuron disease and frontotemporal dementia spectrum conditions. It also compares those findings with matched caregivers, to understand what might be happening in these diseases.
Beijing, Beijing MunicipalityAges 18–80 - NCT04855630Recruiting
Sleep and exercise study for memory changes
This study tests whether improving sleep and increasing exercise can help people with mild memory changes. You'll wear a Fitbit and a sleep headband and use a stationary bike.
Miami, FloridaAges 55–80 - NCT04896775Recruiting
Online program to improve sleep for dementia caregivers
This trial tests a web-based program (NiteCAPP) to help people who care for someone with dementia sleep better. It targets caregivers with ongoing insomnia, and aims to improve sleep and daytime functioning.
Tampa, FloridaAges 18 years+ - NCT04701177Enrolling by invitation
Smartphone-based study of brain biomarkers in memory clinic patients
This observational study follows people with (or at risk for) Alzheimer’s-related brain changes and a comparison group without them. It uses clinic visits, cognitive testing, questionnaires, and possibly a spinal fluid test to better understand brain biomarkers and how they relate to thinking and daily life.
Corfu, CorfuAges 45 years+ - NCT04632628Recruiting
Online sleep coaching for insomnia in dementia caregivers
This trial tests an online form of cognitive behavioral therapy (a structured skills-based program) to improve insomnia for people caring for someone with dementia. It may help reduce trouble falling asleep, staying asleep, or waking too early.
Columbia, MissouriAges 18 years+ - NCT04639622Recruiting
Study for inherited frontotemporal dementia gene risks
This study recruits adults who come from families with certain known gene changes linked to frontotemporal dementia. It aims to learn more about these inherited forms of dementia using brain scans and research blood testing, which will not provide personal results.
LilleAges 18 years+ - NCT04680130Enrolling by invitation
Study of brain, genetics, and clinical symptoms in neurodegenerative illness
This study looks at how your symptoms, brain imaging (MRI), and genetic factors relate to neurodegenerative conditions. It may help researchers better understand what causes these illnesses and how to classify them.
Rochester, MinnesotaAges 21 years+ - NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for dementia?
- Yes. Clin2 currently lists 488 recruiting dementia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a dementia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a dementia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.