Clinical trials · New York, NY
Depression clinical trials in New York
We’re tracking 111 recruiting depression studies with a site in or near New York — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near New York
- NCT05850689RecruitingPhase 3
Lumateperone add-on for major depression that didn’t improve
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
New York, New YorkAges 18–65 - NCT06899165RecruitingPhase 2
Psilocybin therapy for inherited trauma
This trial tests whether psilocybin (a psychedelic substance) combined with therapy can help adult children of genocide survivors who experience symptoms of trauma, depression, or anxiety. The goal is to see if this approach can reduce the emotional impact of intergenerational trauma.
New York, New YorkAges 18 years+ - NCT07717385Recruiting
90-day trial of a probiotic for stress and sleep
This study tests whether a daily probiotic capsule called Neuralli Mood can help adults who feel stressed, have trouble sleeping, or experience low mood. It lasts 90 days and involves taking two capsules each day and filling out online surveys.
New York, New YorkAges 18 years+ - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
New York, New YorkAges 18–74 - NCT07680140RecruitingPhase 4
Using biomarkers to choose depression treatment
This study uses a blood test (biomarker) to help pick the antidepressant that might work best for you. It compares two treatments—standard antidepressants and ketamine—in people with major depression who haven't gotten enough relief from one prior treatment.
New York, New YorkAges 18–70 - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
New York, New YorkAges 18–75 - NCT06901687RecruitingPhase 2
Home brain stimulation for depression in MS
This study tests whether a special, gentle brain stimulation device you can use at home (called tDCS) can help improve depression symptoms in people with multiple sclerosis. You will be supervised over video during the sessions to make sure everything goes smoothly.
New York, New YorkAges 18–65 - NCT04940585Recruiting
Study for pregnant women with stress or depression symptoms
This study supports pregnant people who are in their second trimester and have signs of stress, trauma, or depression. The goal is to learn whether the program can help improve emotional well-being during pregnancy.
New York, New YorkAges 18–100 - NCT07390331Recruiting
Helping heart patients manage depression
This trial tests a program that helps patients with both depression and heart disease take a more active role in their care. It combines support for depression treatment with your regular heart checkups.
New York, New YorkAges 18 years+ - NCT04982757Enrolling by invitation
Accelerated TMS to treat depression or OCD
This trial tests an “accelerated” form of transcranial magnetic stimulation (TMS) to reduce symptoms of depression or obsessive-compulsive disorder (OCD). You may be considered if standard treatments didn’t help (or you couldn’t tolerate them), and if it’s safe for you to receive TMS.
New York, New YorkAges 18–75 - NCT07188467Recruiting
Stress and well-being support for international students
This study tests a self-help program called 'SH+' designed to reduce stress and improve well-being in international students at The New School. If you are an international student feeling at least mildly distressed, this program may help you develop coping skills.
Brooklyn, New YorkAges 18 years+ - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Brooklyn, New YorkAges 18–65 - NCT06004414Recruiting
SilverCloud mental health app study for high school students
This study tests a mental health app called SilverCloud in high school students who are feeling anxious or depressed. It aims to see if the app can help improve their mood and wellbeing.
Brooklyn, New YorkAges 13–22 - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT07822321RecruitingPhase 3
Brexanolone for severe postpartum depression
This trial tests an investigational medicine to help mothers with severe depression that started late in pregnancy or shortly after childbirth. It aims to improve mood and overall well-being.
Manhattan, New YorkAges 15–45 - NCT06096207RecruitingPhase 1
Deep brain stimulation for severe depression
This trial tests whether deep brain stimulation (DBS) — a surgical treatment that uses tiny electrical pulses to change brain activity — can help people with severe, long-lasting depression that hasn't responded to other treatments.
Queens, New YorkAges 18–65 - NCT06854224RecruitingPhase 2
Testing a sleep drug for suicide risk in veterans with depression
This trial tests whether a medication called suvorexant (used for sleep) can help lower suicide risk in veterans who have major depression and have attempted suicide before. The study aims to see if blocking a brain chemical called orexin reduces suicidal thoughts.
The Bronx, New YorkAges 18–70 - NCT07775300RecruitingPhase 3
Study of an injectable drug for major depressive disorder
This study tests an investigational drug called brenipatide for major depressive disorder. It is given as a self-injection and is being compared to a placebo to see if it helps improve depression symptoms in people who are already on standard treatment.
The Bronx, New YorkAges 18–75 - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT05734313Recruiting
Teletherapy CBT for anxiety and depression in people with diabetes
This trial tests a unified, talk-therapy program delivered by video (telemedicine) to help with anxiety and depressive symptoms. If you have type 1 diabetes and symptoms of anxiety or depression, it may help you learn coping skills and improve mood.
The Bronx, New YorkAges 18–64 - NCT06508450Recruiting
Mental health support for minority young adults
This trial tests a program to help racial and ethnic minority young adults engage with mental health services. It aims to improve access and participation in care.
The Bronx, New YorkAges 18–34 - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Irvington, New JerseyAges 10–17 - NCT06991166Recruiting
A therapy study for new mothers with depression whose baby is in the NICU
This study tests a new talk therapy program to help new mothers with depression whose babies are in the neonatal intensive care unit (NICU). You may join if you gave birth in the last year and have signs of depression, like a diagnosis or certain feelings.
Hackensack, New JerseyAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Staten Island, New YorkAges 18–70
Hear when a new Depression trial opens near New York, NY
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Depression trials in other cities
Where these studies are running near New York
Institutions with a site for the recruiting depression studies listed above.
- NYU Langone Health · 3 studies
- Adams Clinical Harlem · 2 studies
- Weill Cornell Medicine · 2 studies
- Adams Clinical Bronx
- Albert Einstein College of Medicine
- Bio Behavioral Health
- Columbia University Irving Medical Center
- Duplicate_NeuroCognitive and Behavioral Institute, Inc /ID# 227077
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in New York.
Common questions
- Are there depression clinical trials near New York?
- Yes. We're currently tracking 111 recruiting depression studies with a site near New York, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near New York?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in New York to take part?
- Not necessarily. These studies have a site near New York, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near New York regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.