Clinical trials
Differentiated Thyroid Cancer clinical trials
Below are recruiting differentiated thyroid cancer clinical trials, each written for real people, not researchers. We’re tracking 65 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06730321Recruiting
Assessing skills for robotic thyroid surgery
This trial is for people having robotic thyroid surgery (removing all or part of the thyroid with a robot). It aims to create a scoring system to measure how well surgeons perform the procedure. You may be eligible if you have a small thyroid cancer or a benign nodule and want the best cosmetic result.
ShanghaiAges Any age - NCT06787911RecruitingPhase 2
Donafenib and immunotherapy before surgery for advanced thyroid cancer
This trial tests a combination of two drugs—donafenib (a targeted therapy) and an immunotherapy (anti-PD-1 antibody)—given before surgery for locally advanced differentiated thyroid cancer. The goal is to shrink the tumor to make surgery easier and more complete. If you have this type of thyroid cancer that is hard to remove completely with surgery alone, this study may be an option.
ShanghaiAges 18–80 - NCT06853925Recruiting
Online program for thyroid cancer symptom management
This study tests a web-based program to help people with thyroid cancer manage symptoms from radioactive iodine (RAI) treatment and improve their quality of life. It is for those who have had RAI within the past three years and are experiencing mild to moderate symptoms.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06860971RecruitingPhase 3
AL2846 capsule vs placebo for advanced thyroid cancer
This study tests a new oral capsule (AL2846) against a placebo in people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if AL2846 can slow or stop cancer growth.
Hefei, AnhuiAges 18–75 - NCT06898437RecruitingEarly Phase 1
Lutetium-177 LNC1004 for advanced thyroid cancer that no longer responds to standard treatments
This trial tests a radioactive drug called 177Lu-LNC1004 for people with a type of thyroid cancer that is no longer responding to standard treatments. The drug targets a protein called FAP found on tumor cells, which may help shrink tumors and slow disease progression.
BeijingAges 18–85 - NCT06902376RecruitingPhase 1
XL092 and cemiplimab for advanced thyroid cancer without BRAF mutation
This trial tests a combination of two drugs, XL092 and cemiplimab, for people with a rare and aggressive type of thyroid cancer called anaplastic thyroid cancer. The drugs aim to shrink tumors before surgery and help the immune system fight the cancer.
Boston, MassachusettsAges 18 years+ - NCT06923826RecruitingPhase 2
Study of sacituzumab govitecan for advanced salivary gland and thyroid cancers
This trial tests a drug called sacituzumab govitecan in people with advanced salivary gland cancer or thyroid cancer that has spread or cannot be removed. The goal is to see if the drug can help shrink or slow down the cancer.
SingaporeAges 21 years+ - NCT06959641RecruitingPhase 2
XL092 for advanced thyroid cancer that no longer responds to radioactive iodine
This trial is testing a new oral medication, XL092, for people with advanced thyroid cancer that has stopped responding to radioactive iodine therapy. The goal is to see if XL092 can slow or stop the cancer from growing.
Torrance, CaliforniaAges 18 years+ - NCT06961084RecruitingPhase 2
I-124 PET/CT scan for diagnosing thyroid cancer
This trial tests whether a new type of scan (I-124 PET/CT) can better detect thyroid cancer compared to standard scans. It may help doctors decide on the best treatment, such as radiation therapy or surgery.
San Francisco, CaliforniaAges 13 years+ - NCT06970353RecruitingPhase 2
Study of tunlametinib for NRAS-mutant advanced thyroid cancer
This trial tests a targeted drug (tunlametinib) for advanced thyroid cancer that has a specific genetic change called NRAS mutation. It may help people whose cancer is not responding to standard treatments like radioactive iodine.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07068542Recruiting
New drug combo for advanced thyroid cancer
This trial tests a new drug called sacituzumab tirumotecan combined with immunotherapy for people with advanced thyroid cancer that cannot be removed by surgery or has spread. It aims to see if this combination can help shrink tumors or slow down the cancer.
Hangzhou, ZhejiangAges 18 years+ - NCT07092514RecruitingPhase 2
Comparing two doses of lenvatinib for thyroid cancer not helped by iodine
This study compares two doses of lenvatinib (24 mg vs 10 mg per day) to see which works better for people with thyroid cancer that no longer responds to radioactive iodine. It's for those whose cancer is growing or causing symptoms.
St Louis, MissouriAges 18 years+ - NCT05538130RecruitingPhase 1
Study medicine for BRAF-mutated advanced solid tumors
This Phase 1 trial studies how PF-07799544 works and what dose is safest in people with advanced cancer that has a specific genetic change called BRAF V600. You may receive it alone or with another treatment, depending on the tumor group, to see if it can treat the cancer.
Birmingham, AlabamaAges 16 years+ - NCT07419932Recruiting
Pre-surgery treatment for advanced thyroid cancer
This study tests whether giving treatment before surgery (neoadjuvant therapy) helps people with locally advanced thyroid cancer. It aims to shrink the tumor so surgery can be more successful.
Fuzhou, FujianAges 14–80 - NCT07436455Recruiting
New PET scan for thyroid cancer detection
This trial tests a new type of PET scan (F-18 Tetrafluoroborate) to find thyroid cancer cells that don't show up on standard scans. It's for people who have had surgery and radioactive iodine therapy but still have signs of cancer in their blood tests.
Ankara, AnkaraAges 18 years+ - NCT07438847RecruitingPhase 1
New radioactive treatment for advanced thyroid cancer
This trial tests a new radioactive treatment (177Lu-CTR-FAPI) that targets a protein on thyroid cancer cells. It's for people whose thyroid cancer has stopped responding to standard treatments, including radioactive iodine and targeted therapies.
BeijingAges 18 years+ - NCT06261190Enrolling by invitation
Active monitoring for low-risk thyroid cancer
This trial tests whether it is safe to avoid immediate surgery and instead monitor small thyroid cancers that are considered low-risk. If you join, doctors will check regularly to make sure the cancer does not grow or spread.
Goyang-siAges 18 years+ - NCT06195228RecruitingPhase 4
Real-world study of genetic types in advanced thyroid cancer
This study looks at how different genetic types of advanced thyroid cancer respond to treatment in real-world settings. It may help doctors choose the best therapy for you based on your tumor’s genetic makeup.
Fuzhou, FujianAges Any age - NCT04892303RecruitingPhase 1
Planning treatment using radiation plus radioactive iodine for thyroid cancer
This Phase 1 study tests how doctors plan a combination of two radiation approaches—external beam radiation and radioactive iodine—for thyroid cancer that is not fully responding to standard treatment. It may help people who still have iodine-avid tumor spots, but whose iodine uptake looks too low to work well with radioactive iodine alone.
Baltimore, MarylandAges 18–85 - NCT06959511RecruitingPhase 2
Zanzalintinib for advanced thyroid cancer before surgery
This trial tests a drug called zanzalintinib for people with advanced thyroid cancer that has spread nearby. The goal is to see if taking this pill before surgery can shrink the tumor and make it easier to remove.
Ann Arbor, MichiganAges 18 years+ - NCT07376837Recruiting
Radiofrequency ablation for small low-risk thyroid cancer
This study tests whether radiofrequency ablation (a heat-based treatment applied through the skin) can safely and effectively cure small, low-risk papillary thyroid cancers. It is designed for people whose tumors are small, have not spread, and who either cannot have surgery or prefer not to.
Toronto, OntarioAges 18 years+ - NCT05599139Recruiting
Testing iodine uptake after a low-iodine diet
This study looks at how much iodine your body absorbs after you follow a low-iodine diet before radioactive iodine treatment (131I) for thyroid cancer. It may help improve how safely and effectively this treatment is planned.
Groningen, Provincie GroningenAges 18–75 - NCT06855680Recruiting
EMIRATES: Observing low-risk thyroid cancer without completion surgery
This study tests whether it is safe to monitor small, low-risk thyroid cancers (1–4 cm) instead of removing the remaining thyroid tissue after initial surgery. It may help you avoid a second operation and lifelong medication if your cancer is truly low-risk.
WiganAges 18 years+ - NCT06671184Recruiting
Predicting difficult thyroid surgery for less scarring
This trial looks at a tool doctors can use to predict if a certain type of thyroid surgery (through the mouth or under the chin) will be challenging. It helps people who want less visible scarring after their thyroid cancer surgery.
Shanghai, Shanghai MunicipalityAges Any age
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Common questions
- Are there clinical trials for differentiated thyroid cancer?
- Yes. Clin2 currently lists 65 recruiting differentiated thyroid cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a differentiated thyroid cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a differentiated thyroid cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.