Clinical trials
Disc Disease clinical trials
Below are recruiting disc disease clinical trials, each written for real people, not researchers. We’re tracking 76 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80 - NCT04601363Recruiting
Personalized spine registry for people with spinal hardware
This registry follows people who recently had spinal surgery where custom (patient-specific) spine hardware (like rods) was placed. It collects consent and health questionnaires to learn how these implants affect patients over time.
Aurora, ColoradoAges 10–85 - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT05238740Recruiting
Compare fusion results after two spine surgeries with added biologics
This study compares two types of spine surgery (ALIF or XLIF) for one spinal level, and tests how well the bones fuse when a specific bone-forming product is used. It also looks at how patients feel and function after surgery.
BernAges 18–70 - NCT05329129Recruiting
Spine surgery registry to track recovery with bone graft
This study follows people who are having spinal fusion surgery using an OssDsign bone graft. It collects health and scan information over time to better understand recovery and outcomes after surgery.
Fresno, CaliforniaAges 21 years+ - NCT05883436Recruiting
Testing a specific neck fusion implant for nerve pain
This trial studies a specific implant used to fuse certain neck discs (C3 to C7) in people with nerve-related arm symptoms. It may help by supporting healing of the painful, damaged disc(s) and improving arm pain or numbness.
Orange, CaliforniaAges 18 years+ - NCT06053242RecruitingPhase 1/Phase 2
Stem cell injection for long-term low back pain
This trial tests a new stem cell injection (CELZ-201-DDT) into a muscle to treat chronic lower back pain that hasn't improved with standard treatments. It aims to see if the injection is safe and effective for people aged 18 to 80 with moderate to severe back pain.
Aventura, FloridaAges 18–80 - NCT06226272Recruiting
Study of Stryker spine device results
This trial is checking how well a Stryker spine device works in people who need spine surgery. Eligibility depends on the specific device and is decided by the study doctors.
Jacksonville, FloridaAges 18 years+ - NCT06438471RecruitingPhase 1
Study of a new drug for nerve pain after spinal cord injury
This trial tests an experimental pill for people with spinal cord injury who have long-term nerve pain. It aims to see if the drug can reduce pain and be safe.
Augusta, GeorgiaAges 18 years+ - NCT06352710Recruiting
Tracking recovery after brain or spine surgery
This study uses a smartphone app to track how you recover after brain or spine surgery. It helps doctors understand how side effects affect your daily life, so they can improve care.
Sankt Gallen, St.GallenAges 18 years+ - NCT06490887Recruiting
Spine unit modeling with high-throughput analysis (SUIT)
This study looks at cells from people with degenerated discs or from donated fat or placenta tissue. It aims to understand how these cells work and might help develop new treatments for back pain.
Milan, MIAges 18–60 - NCT06601634Recruiting
Neck pain improvement after cervical spine surgery
This study looks at what factors help predict better neck pain after a specific type of neck surgery called ACDF. If you have a degenerative neck condition and are scheduled for this surgery, the results could help doctors understand what leads to the best pain relief.
Krakow, Lesser Poland VoivodeshipAges 18–65 - NCT05037968Recruiting
Test bone graft materials for multi-level back fusion surgery
This trial compares two bone-graft materials to help bones heal after back fusion surgery using a rod/screw system. It may help people who have ongoing back or leg pain despite at least 3 months of non-surgical treatments.
Hartford, ConnecticutAges 18 years+ - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65 - NCT06825390Recruiting
Ear stimulation and brain imaging for chronic low back pain
This study tests if a non-invasive ear stimulation technique can change brain activity linked to chronic low back pain. You would have a brain scan before and after the treatment to see how your brain responds.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06971835Enrolling by invitation
NanoParticle Matrix spine surgery registry
This study follows people who receive a special bone graft material called NanoParticle Matrix (NPM) during spine surgery. Researchers want to track outcomes over two years to see how well it works.
Baton Rouge, LouisianaAges 18 years+ - NCT06686017Enrolling by invitation
New bone graft for lower back fusion surgery
This trial studies a new bone graft material called Virtuos for use in lower back spinal fusion surgery. It may help patients needing a one or two-level lumbar fusion by providing a safe and effective option for bone healing.
South Bend, IndianaAges 18 years+ - NCT06415123Enrolling by invitation
Study comparing new bone graft to standard for spinal fusion
This study tests a new bone graft material (MagnetOs Flex Matrix) compared to a standard bone graft for spinal fusion surgery. It may be an option if you have ongoing back or leg pain that hasn't improved with other treatments and you need a one-time fusion of up to 4 levels in your lower back.
Southfield, MichiganAges 18 years+ - NCT06000319Enrolling by invitation
NMP fibers for spine fusion surgery
This study tests a new material called NMP fibers used during spine fusion surgery to treat conditions like degenerative disc disease, spinal stenosis, or spondylolisthesis. The goal is to see how well it works for patients having fusion in the neck or lower back.
Jasper, AlabamaAges 18 years+ - NCT05812092Enrolling by invitation
Surgery for one or two levels of neck disc degeneration
This trial studies whether an operation to remove and decompress damaged neck discs (and fuse the area) helps people with painful nerve problems in the neck/arm. It’s meant for cases where non-surgery treatments haven’t worked and imaging shows the problem matches your symptoms.
Fort Worth, TexasAges 18 years+ - NCT04689854Enrolling by invitation
Cervical spine surgery implant study for neck disc problems
This trial studies specific neck (cervical) spine implants used during surgery for degenerative disc disease or neck instability, along with a particular kind of bone grafting and supporting hardware. It may help patients by testing whether these devices and the planned fusion approach work safely and effectively in real-world surgery.
Orange, CaliforniaAges 18 years+ - NCT04418830Enrolling by invitation
Study of a spine cage implant for degenerative back problems
This trial studies how well specific lumbar (lower back) implant “cages” help fuse vertebrae in people with degenerative disc disease, spinal slippage, narrowing, curvature, or forward-bending deformity. It may help by testing an approach to improve stability and reduce symptoms after surgery.
La Jolla, CaliforniaAges 18 years+ - NCT04204135Enrolling by invitation
Tracking hip flexor weakness after specific spine surgeries
This trial follows how hip flexor strength changes after two types of lower-back surgeries (ALIF or LLIF). It may help doctors better predict and prevent weakness in the hip and leg after surgery.
Chicago, IllinoisAges Up to 65 years
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Common questions
- Are there clinical trials for disc disease?
- Yes. Clin2 currently lists 76 recruiting disc disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disc disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disc disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.