Clinical trials
Disc Disease clinical trials
Below are recruiting disc disease clinical trials, each written for real people, not researchers. We’re tracking 76 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT06462729RecruitingPhase 1/Phase 2
Testing a new bone graft for lower back fusion surgery
This trial tests a new bone graft material called LDGraft for people who need a single-level lower back fusion (anterior lumbar interbody fusion). It aims to see if the new graft is as good as or better than current options for helping bones heal together.
Fort Wayne, IndianaAges 22–80 - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT07370493Enrolling by invitation
Study of a two-level disc implant for the neck
This study looks back at patients who already have a Prodisc C Vivo device in two levels of their neck spine. The goal is to learn how well the surgery works over time.
RecklinghausenAges Any age - NCT05691231Enrolling by invitation
Follow-up study for the NuVasive Simplify Disc implant
This study checks how safe and how well a specific artificial disc (the NuVasive Simplify Disc) works over the long term at two implant sizes/levels. It is for people who were already enrolled in an earlier disc study and are still willing to participate.
Charlotte, North CarolinaAges 18 years+ - NCT07254806RecruitingPhase 3
Cell therapy for low back pain from disc disease
This study tests if injecting a special cell therapy into a damaged spinal disc can reduce chronic low back pain. It is for people who have had low back pain for at least 6 months and haven't gotten enough relief from other treatments like physical therapy or pain medication.
Birmingham, AlabamaAges 18–75 - NCT05287867Recruiting
Study for painful degenerative disc disease treatment
This trial is testing a treatment approach for people with long-lasting, painful worn-out discs in the lower back (and sometimes leg pain). It looks for people who tried common non-surgical options without enough relief and who may be headed toward a lumbar procedure.
Broomfield, ColoradoAges 25–65 - NCT05971329Recruiting
Pilot study of bone graft for cervical disc wear and nerve symptoms
This trial tests a new bone graft product (ZetaFuse™) used during front-of-the-neck surgery to treat “wear and tear” in the cervical (neck) discs causing nerve problems. It may help relieve pain and nerve-related symptoms when other treatments haven’t worked.
Randwick, New South WalesAges 22–75 - NCT07017634RecruitingPhase 3
Novosis Putty for spine fusion in lumbar disc disease
This trial tests a new bone graft putty (Novosis Putty) used during a specific type of spine fusion surgery (TLIF) to treat a worn-out disc causing low back and leg pain. The goal is to see if it works as well as or better than current options.
Baton Rouge, LouisianaAges 21–80 - NCT04042844RecruitingPhase 2
Single injection treatment for chronic low back disc pain
This Phase 2 study tests whether one injection of BRTX 100 can reduce pain and improve function in people with chronic, disc-related low back pain. It looks for whether the treatment is safe and works better than what you’ve already tried.
Birmingham, AlabamaAges 18 years+ - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT04770571Enrolling by invitation
Study of posterior neck and upper-back spine fixation systems
This trial studies specific surgical hardware used to stabilize the back of the neck and upper back during spine surgery. It may help surgeons compare outcomes for people needing fixation for trauma, instability, failed prior fusion, tumors, or certain degenerative conditions.
Orange, CaliforniaAges 18 years+ - NCT07187973RecruitingPhase 1
Study of DISC-3405 for people with sickle cell disease
This trial tests an investigational drug called DISC-3405 in people with sickle cell disease (SCD) to see if it is safe and how it affects your body. It may be an option if you have certain SCD complications or lab results.
Birmingham, AlabamaAges 18 years+ - NCT04623593Recruiting
Study of cost and value of neck disc surgery
This study looks at how cost-effective (good value for the money) anterior neck disc surgery is for people with nerve or spinal cord symptoms. If you need this type of operation, it may help doctors better choose treatments and plan healthcare resources.
Maastricht, LimburgAges 18 years+ - NCT06485206Recruiting
Hybrid disc replacement and fusion for two-level neck disease
This study tests a combination of a disc replacement (Mobi-C) and a spinal fusion (ACDF) for people with degenerative disc disease at two levels in the neck. The goal is to see if this approach is safe and effective for relieving pain and nerve symptoms.
Sacramento, CaliforniaAges 22–69 - NCT07060235Enrolling by invitation
Mobile app for disc herniation recovery
This trial tests a mobile app that guides you through exercises for disc herniation. The app is designed to help strengthen the muscles that support your spine and may reduce pain.
AnkaraAges 20–55 - NCT05066711Enrolling by invitation
Study of a neck surgery implant for adults
This trial looks at using a specific implant system during planned front-of-the-neck surgery (C2 to C7) for common neck problems like disc degeneration, injury, or spinal narrowing. It may help doctors compare outcomes with this particular hardware and surgical approach.
Naperville, IllinoisAges 18 years+ - NCT04641039Recruiting
Study of scar differences after lumbar disc replacement
This study compares how postoperative scars look and behave after certain lumbar disc replacement surgery. It may help doctors choose approaches that reduce excessive scar-related problems after surgery.
Valencia, ValenciaAges 18–50 - NCT06383949Recruiting
Real-world study of Synergy Disc implant
This study follows people who receive a Synergy Disc implant to treat neck pain or nerve problems. It collects real-world information on how well the disc works and how safe it is over time.
DublinAges 21 years+ - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT06383962Recruiting
Synergy Disc cervical disc replacement outcomes study
This trial is for people who are getting or have already received a Synergy Disc implant to replace a damaged disc in the neck. It follows patients over time to see how well the disc performs in relieving nerve pain or spinal cord compression.
BirminghamAges 21 years+ - NCT06415136Enrolling by invitation
Comparing two ways to fuse neck bones after prior surgery
This study tests two methods for adding a new fusion to the level next to a previous neck surgery. It compares using a special plate system versus removing the old plate and putting in a new one.
Southfield, MichiganAges 18 years+ - NCT04775537Recruiting
OssiMend bone graft for lumbar spine fusion surgery
This trial studies whether OssiMend bone graft helps heal a lumbar spine fusion for people whose disc disease has not improved with non-surgical care. It may be an option if you need back surgery due to specific spine wear-and-tear changes.
Encinitas, CaliforniaAges 18 years+ - NCT05997121Recruiting
Testing a new spinal implant for degenerative disc disease
This trial studies a new spinal implant system (Hexanium TLIF) for people with degenerative disc disease. It aims to see if the implant is safe and works well to help with back pain and stability.
BrugesAges 18 years+
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Common questions
- Are there clinical trials for disc disease?
- Yes. Clin2 currently lists 76 recruiting disc disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disc disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disc disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.