Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,057 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05947955RecruitingPhase 2
Study drug for infection-related lung failure in adults
This Phase 2 trial tests Rhu-pGSN in adults with acute respiratory distress syndrome (ARDS) caused by an infection. If you qualify, the study may help determine whether the drug improves outcomes in this short-term, life-threatening lung condition.
Los Angeles, CaliforniaAges 18 years+ - NCT05935215RecruitingPhase 3
Switch from anti-C5 shots to iptacopan for aHUS
This trial tests whether people with atypical hemolytic uremic syndrome (aHUS) who are doing well on anti-C5 treatment can safely switch to iptacopan. It focuses on both effectiveness (blood counts and kidney function) and safety after the switch.
Nanjing, JiangsuAges 18–100 - NCT05926505RecruitingPhase 2/Phase 3
Anakinra for lingering symptoms after COVID-19
This Phase 2/3 trial studies whether anakinra can improve ongoing (post-acute) COVID-19 symptoms lasting for more than two months. It mainly looks for better safety and symptom improvement in people with specific inflammation and lung-related findings.
JenaAges 18 years+ - NCT05800821Recruiting
Predicting brain blood-flow problems after carotid surgery
This study uses deep learning to predict which people are at risk for “cerebral hyperperfusion syndrome” (a dangerous spike in brain blood flow) after carotid revascularization. If you qualify, they’ll use scans/tests to estimate your risk so doctors can watch you more closely if needed.
MinskAges 30–80 - NCT05859997Enrolling by invitation
CAR-T cell therapy for active autoimmune disease flare-ups
This study tests an immune-cell treatment (CAR-T, called BRL-301) in people with certain autoimmune diseases that are active and hard to control. It may help your immune system calm down if standard treatments have not worked or your disease has returned.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT05865600Recruiting
PET/CT guided planning for treatment in chronic coronary disease
This trial uses a heart scan (PET/CT) to better estimate blood flow in people with long-term coronary artery disease. It aims to help doctors choose the best treatment strategy and decide who may need more invasive testing or procedures.
Herning, Central JutlandAges 18 years+ - NCT05777889Recruiting
Infrared imaging for nerve-stimulation pain in one leg
This study uses infrared images to help evaluate spinal cord stimulation for complex regional pain syndrome (CRPS) when it affects one leg. It aims to see whether the imaging approach matches pain and treatment needs in people whose pain hasn’t improved with standard care.
New York, New YorkAges 18–85 - NCT04232085RecruitingPhase 2
Stem cell transplant to rebuild immunity in genetic immune disorders
This Phase 2 trial tests a stem cell (bone marrow) transplant approach to restore bone marrow function and immune function in people with certain inherited immune problems. If you have one of these conditions and a suitable donor, the study may offer a path to rebuild blood and immune systems.
Baltimore, MarylandAges 4 months–50 years - NCT05847179RecruitingPhase 2
Treating bone weakness in Werner syndrome
This study tests an investigational drug for people with Werner syndrome who have weak bones (osteopenia or osteoporosis). The goal is to see if the drug is safe and can help improve bone health.
Ann Arbor, MichiganAges 18 years+ - NCT05825131Recruiting
Natural history study for Sanfilippo type C disease
This study follows people with Sanfilippo syndrome type C to better understand how the disease changes over time. It does not appear to test a new medicine; instead, it collects health and development information that can help future treatments.
Dallas, TexasAges 1 year+ - NCT05830721Recruiting
Monitoring leg pressure in adults on life-support
This trial tests a device that continuously measures pressure in an arm or leg to help detect compartment syndrome in people on a heart-lung machine (VA-ECMO). It may help clinicians act sooner if pressure becomes dangerous, potentially reducing complications.
Baltimore, MarylandAges 18 years+ - NCT05838235Recruiting
Exercise program for kids with Marfan syndrome
This trial studies an adapted physical activity (exercise) program to support effort rehabilitation in children and teens with Marfan syndrome. It may help safely improve activity and fitness while monitoring heart-related risks.
ToulouseAges 7–17 - NCT05814497Recruiting
Brain scan study of how kids process chronic pain
This study looks at how the brain processes pain sensations in children with certain long-lasting pain conditions. It may help researchers understand what’s happening in the nervous system and guide better treatments.
Cincinnati, OhioAges 10–17 - NCT05819853RecruitingPhase 3
Semaglutide to help restart periods in PCOS
This Phase 3 study tests whether semaglutide can help people with polycystic ovary syndrome (PCOS) start ovulating and having more regular periods. You may join with or without metformin, and contraception rules are important because the medicine must not be used during pregnancy.
Aurora, ColoradoAges 12–35 - NCT05785000Recruiting
Rehab program for long-lasting concussion symptoms
This trial tests a rehabilitation approach for people with post-concussion syndrome (ongoing symptoms after a mild head injury). It may help by guiding safer, structured recovery—especially through exercise—if it fits your situation and you can participate.
Copenhagen, Region of Greater CopenhagenAges 18–70 - NCT05805605RecruitingPhase 2
Low-intensity stem cell transplant with donor cells and blood-protection
This Phase 2 study tests a low-intensity bone marrow/stem cell transplant using a matched donor plus two medicines to help prevent the donor cells from attacking you. It aims to treat certain blood cancers—especially when standard treatment has not fully worked or when you are in remission but at higher risk.
Minneapolis, MinnesotaAges Up to 75 years - NCT05791604Recruiting
Study prebiotics and probiotics to help children with Prader-Willi
This trial studies whether taking prebiotics and probiotics can help children with Prader-Willi syndrome manage obesity. It’s testing a gut-focused approach to weight control over the study period.
Shanghai, Shanghai MunicipalityAges 3–10 - NCT05795465RecruitingPhase 2
Study drug for people with acute respiratory distress syndrome
This Phase 2 trial tests GEn-1124 to see if it can improve outcomes in people with acute respiratory distress syndrome (ARDS). You may be eligible if the study drug can be started very soon after ARDS is diagnosed and if you meet the safety and health requirements.
Washington D.C., District of ColumbiaAges 18–85 - NCT05789056RecruitingPhase 2/Phase 3
Study lotion for Netherton syndrome safety and symptom improvement
This trial tests a prescription lotion (QRX003) to see if it is safe and helpful for people with Netherton syndrome. Because the study checks skin symptoms on certain body areas and closely controls other treatments, it may be best for patients who can keep their current regimen stable.
San Diego, CaliforniaAges 14 years+ - NCT05147649Recruiting
Brain scan study in severe sleep apnea without CPAP
This trial uses a specialized brain scan (MRI) to study people with severe obstructive sleep apnea who are not using CPAP. It also compares them with people who do not have sleep apnea to understand how brain function differs.
ReimsAges 18–75 - NCT05664412Recruiting
Brain stimulation trial to improve thinking in 22q11.2 deletion
This trial tests a non-invasive brain stimulation approach to help improve executive function—skills like planning, attention, and self-control—in people with 22q11.2 deletion syndrome. If you qualify, you would be asked to participate and allow study procedures to see whether this treatment helps.
Geneva, Canton of GenevaAges 14–25 - NCT05757960Enrolling by invitation
Physiotherapy program for jaw pain in hEDS
This study tests a tailored physical therapy (physiotherapy) approach for jaw pain caused by temporomandibular disorder (TMD) in people with hypermobile Ehlers-Danlos syndrome (hEDS). It may help reduce jaw muscle and joint pain and improve function.
MünsterAges 18 years+ - NCT05765071Recruiting
Botulinum injections for lower leg exertional muscle pressure pain
This trial studies whether injecting botulinum (a medicine that relaxes overactive muscles) into the lower leg can reduce pain and pressure during exercise in people with a confirmed condition called chronic exertional compartment syndrome. It may help by lowering the muscle compartment pressure that builds up after activity.
Calgary, AlbertaAges 18–50 - NCT05732103RecruitingPhase 1/Phase 2
Testing CTX-712 for AML or high-risk MDS after prior treatment
This early-phase study tests CTX-712, a new cancer treatment, in people whose acute myeloid leukemia (AML) or certain high-risk blood cancers came back or did not respond to prior therapy. It may help shrink the cancer and control the disease by targeting it differently than standard treatments.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,057 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.