Clinical trials
Drug Resistant Epilepsy clinical trials
Below are recruiting drug resistant epilepsy clinical trials, each written for real people, not researchers. We’re tracking 59 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06545214Recruiting
Breathing and arousal in drug-resistant epilepsy
This study looks at breathing problems during seizures in people with drug-resistant focal epilepsy. It aims to understand why some people stop breathing or have low oxygen during seizures, which could help prevent sudden death in epilepsy.
Bron, RhoneAges 18–55 - NCT06557720Recruiting
Imaging study for hard-to-control epilepsy
This study looks at how different brain scans (like MRI, PET, and EEG) can help find the exact spot where seizures start in people whose epilepsy hasn't been controlled by medicines. It aims to better understand drug-resistant epilepsy so doctors can plan more accurate treatments.
Xi'anAges 18–65 - NCT06708143Recruiting
Temporal interference therapy for drug-resistant epilepsy
This study tests a new, non-invasive treatment called 'temporal interference' for people whose epilepsy seizures are not controlled by medication. It aims to reduce seizures by using low-level electrical fields to calm overactive brain cells.
Beijing, Beijing MunicipalityAges 6–60 - NCT06719791RecruitingEarly Phase 1
Sirolimus for hard-to-treat focal epilepsy
This trial tests if the drug sirolimus can help people with focal seizures (starting in one part of the brain) that don't improve with at least two other medications. It aims to reduce seizure frequency in adults aged 18 to 60.
BeijingAges 18–60 - NCT06794606Recruiting
Study for drug-resistant focal epilepsy
This trial looks at ways to diagnose and treat focal epilepsy that isn't controlled by medications. It includes patients with or without a visible brain lesion on imaging.
MilanAges 18 years+ - NCT07010445Recruiting
Gut-brain connection in resistant epilepsy
This study looks at how the gut and brain talk to each other in people with epilepsy, especially when seizures are hard to control. It may help find new ways to treat epilepsy by focusing on the gut.
Milan, LombardyAges 3–50 - NCT07013331Recruiting
Brain scan study for Dravet syndrome
This study uses a special PET-MRI scan to look at a brain chemical pathway linked to serotonin (a mood-regulating substance) in people with Dravet syndrome or certain types of epilepsy, and in healthy volunteers. It may help understand how the brain works in these conditions.
Bron, RhoneAges 18–60 - NCT07095933RecruitingEarly Phase 1
Everolimus for hard-to-control focal epilepsy
This study tests whether the medicine everolimus (taken as a pill) can safely reduce seizures in adults with focal epilepsy that hasn't been controlled by other treatments. You would continue your current seizure medicines and add everolimus.
Beijing, Beijing MunicipalityAges 18–60 - NCT07145489Recruiting
Infrared light therapy for seizures
This trial tests whether shining a special infrared light on the scalp can reduce seizures in adults with epilepsy that is not controlled by standard medications. You would receive the light treatments and keep a diary of your seizures.
Boston, MassachusettsAges 18 years+ - NCT07680842Recruiting
Non-invasive ultrasound for drug-resistant epilepsy
This study tests a non-invasive focused ultrasound treatment for people with epilepsy that doesn't respond to medications. The goal is to see if this gentle ultrasound can reduce seizures without surgery.
San Francisco, CaliforniaAges 21–65 - NCT02531880RecruitingPhase 1
MRI test of a brain barrier issue in hard-to-treat epilepsy
This early-phase study uses a special MRI approach to look for signs that the “blood-brain barrier” is breaking down in people with drug-resistant epilepsy. It may help researchers understand what is happening in the brain and guide future treatments, though it is primarily a testing/study study.
Bethesda, MarylandAges 18–60 - NCT02890641Recruiting
Study of brain signals and genes in hard-to-treat epilepsy
This study looks at genetic factors and brain electrical activity in children whose seizures are difficult to control with standard medicines. It also involves exams like MRI and possibly procedures under anesthesia, to better understand seizure causes and help future care.
ParisAges 3 months–25 years - NCT06863350Recruiting
Closing a heart hole to treat drug-resistant epilepsy
This trial tests if closing a small hole in the heart (called a PFO) can reduce seizures in people whose epilepsy isn't controlled by medication. It might offer a new treatment option for those who have both drug-resistant epilepsy and this heart condition.
Chengdu, SichuanAges 18–60 - NCT07110688Recruiting
Brain sensing study for mental states
This trial uses sensors and machine learning to understand mental states in healthy adults and people with epilepsy. Researchers aim to improve how we monitor and support mental health.
Downey, CaliforniaAges 18 years+ - NCT05393518Recruiting
Study linking brain signals to anxiety in people with epilepsy
This study looks at how brain electrical signals relate to anxiety symptoms in people with drug-resistant epilepsy. It compares people who do (or do not) meet criteria for generalized anxiety disorder, to better understand anxiety in this setting.
BordeauxAges 18–65 - NCT05459090Recruiting
Study of how brain “brakes” work in drug-resistant temporal epilepsy
This study looks at how the brain’s natural “braking” system works in people with drug-resistant temporal lobe epilepsy. It may help researchers better understand the condition in order to improve future treatments.
Pozzilli, IserniaAges Any age - NCT05534672RecruitingPhase 3
Rapamycin for drug-resistant seizures in tuberous sclerosis
This trial tests whether rapamycin (compared with a placebo) can reduce seizures caused by tuberous sclerosis complex (TSC) that have not been controlled by usual medicines. If you qualify, you may be helping doctors find a safer and more effective option for seizure control.
LodzAges 3 months–50 years - NCT06059157Recruiting
Brain mapping with advanced MRI for epilepsy surgery
This trial uses special MRI scans to create a detailed map of the brain areas causing seizures, helping doctors plan SEEG surgery. It's for people with hard-to-control epilepsy who are already scheduled for SEEG.
BrusselsAges 3 years+ - NCT06309251Recruiting
Ketogenic diet for children with epilepsy or other conditions
This trial studies how well a ketogenic diet works for children with hard-to-treat epilepsy or certain other diseases. It aims to see if the diet improves quality of life.
Milan, MIAges Up to 18 years - NCT06432907Recruiting
Brain signal study during movement in epilepsy patients
This study records brain signals from electrodes already placed in your brain for medical reasons. It looks at how your brain controls movement, which could help develop future devices for people with paralysis.
MoscowAges 18–70 - NCT06663969Recruiting
Temporal Interference Stimulation for Epilepsy
This trial tests a new, gentle way to stimulate specific brain areas using a special electrical signal. It aims to see if this can help people with epilepsy that hasn't improved with medication.
Beijing, Beijing MunicipalityAges 14–65 - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT07399327Recruiting
SEEG thermocoagulation for hard-to-treat epilepsy
This study is looking at how well a procedure called SEEG thermocoagulation (a way to stop seizures by heating a small area of brain tissue) works for people with epilepsy that doesn't improve with medication. By joining, you will help doctors understand why this treatment works for some people and not others.
MarseilleAges 12 years+ - NCT07605858Recruiting
Epilepsy, Sleep, and Brain Activity Study
This study examines how seizures affect sleep quality and dreams in people with hard-to-treat focal epilepsy. Researchers will use specialized brain electrodes to understand these connections during sleep, which may help improve treatment in the future.
Durham, North CarolinaAges 18–55
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Common questions
- Are there clinical trials for drug resistant epilepsy?
- Yes. Clin2 currently lists 59 recruiting drug resistant epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a drug resistant epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a drug resistant epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.