Clinical trials
Drug Resistant Epilepsy clinical trials
Below are recruiting drug resistant epilepsy clinical trials, each written for real people, not researchers. We’re tracking 58 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05670847RecruitingPhase 2/Phase 3
Ketone drinks for drug-resistant epilepsy
This trial tests whether taking “ketone ester” supplements can reduce seizures in people with drug-resistant epilepsy. It may help by changing how the brain uses energy, but you must meet several safety and diet-related conditions.
SohagAges 1–16 - NCT05609084Recruiting
Speech therapy before surgery for drug-resistant temporal epilepsy
This study tests an intensive pre-surgery speech rehabilitation program for people whose seizures come from the language-related area in the temporal part of the brain. The goal is to improve speech outcomes before planned epilepsy surgery.
BordeauxAges 16 years+ - NCT05527093Recruiting
Brain-scan study mapping social thinking changes in epilepsy
This study uses special thinking and brain-scanning tests to understand how “social thinking” may change in people with certain types of epilepsy. You might benefit by having a detailed evaluation during your planned pre-surgery workup.
Gif-sur-YvetteAges 18–65 - NCT04451278Recruiting
Brain scan study to predict outcomes after epilepsy surgery in kids
This trial uses resting-state brain MRI (a scan while you’re not doing a task) to help predict how well children with hard-to-treat epilepsy may do after surgery. If you qualify, you would help researchers see whether the scan can forecast prognosis.
Paris, PARISAges 6–18 - NCT04126369Recruiting
Mindfulness program to improve quality of life in drug-resistant epilepsy
This trial tests whether a mindfulness training program can improve quality of life for people with drug-resistant epilepsy. It looks at whether learning mindfulness skills helps you cope day-to-day alongside your usual treatment.
GrenobleAges 18 years+ - NCT03893916Recruiting
MEG vs EEG tests to find the epilepsy trigger before surgery
This study compares two brain tests—MEG and routine scalp EEG—to pinpoint where seizures start before surgery. It may help doctors choose the safest and most effective plan if you’re being considered for an epilepsy procedure.
BronAges 18–60 - NCT03268824Recruiting
Brain imaging study in drug-resistant focal epilepsy
This study uses MRI brain scans to see how “epileptic discharges” may affect brain connections in the developing brain. It also scans comparison participants without drug-resistant focal epilepsy to help researchers understand what is different.
ParisAges 1.5 years–16 years - NCT02531880RecruitingPhase 1
MRI test of a brain barrier issue in hard-to-treat epilepsy
This early-phase study uses a special MRI approach to look for signs that the “blood-brain barrier” is breaking down in people with drug-resistant epilepsy. It may help researchers understand what is happening in the brain and guide future treatments, though it is primarily a testing/study study.
Bethesda, MarylandAges 18–60 - NCT07640191Recruiting
New Nerve Stimulation Device for Hard-to-Treat Epilepsy
This study tests a new implanted device that stimulates the vagus nerve (a major nerve in your neck) to help reduce seizures in people whose epilepsy doesn't respond well to medications. The device is surgically placed under the skin and may help lower how often you have seizures.
Herston, QueenslandAges 4–75 - NCT07823465Enrolling by invitation
Brain device study for teens with focal epilepsy
This study looks at how well an implanted brain device works for teenagers with focal epilepsy that doesn't improve with medicine. The device sends small electrical pulses to specific brain areas to reduce seizures, and this study will help learn if it's safe and helpful for teens.
Waltham, MassachusettsAges 13–19 - NCT07716930Enrolling by invitation
Eye scan study for drug-resistant epilepsy
This study uses a special eye scan (OCT) to look for changes in the retina that might be linked to hard-to-control epilepsy. The goal is to find new biomarkers that could help doctors better understand and manage the condition.
IstanbulAges 18–40 - NCT06863350Recruiting
Closing a heart hole to treat drug-resistant epilepsy
This trial tests if closing a small hole in the heart (called a PFO) can reduce seizures in people whose epilepsy isn't controlled by medication. It might offer a new treatment option for those who have both drug-resistant epilepsy and this heart condition.
Chengdu, SichuanAges 18–60 - NCT07399327Recruiting
SEEG thermocoagulation for hard-to-treat epilepsy
This study is looking at how well a procedure called SEEG thermocoagulation (a way to stop seizures by heating a small area of brain tissue) works for people with epilepsy that doesn't improve with medication. By joining, you will help doctors understand why this treatment works for some people and not others.
MarseilleAges 12 years+ - NCT07110688Recruiting
Brain sensing study for mental states
This trial uses sensors and machine learning to understand mental states in healthy adults and people with epilepsy. Researchers aim to improve how we monitor and support mental health.
Downey, CaliforniaAges 18 years+ - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06663969Recruiting
Temporal Interference Stimulation for Epilepsy
This trial tests a new, gentle way to stimulate specific brain areas using a special electrical signal. It aims to see if this can help people with epilepsy that hasn't improved with medication.
Beijing, Beijing MunicipalityAges 14–65 - NCT06059157Recruiting
Brain mapping with advanced MRI for epilepsy surgery
This trial uses special MRI scans to create a detailed map of the brain areas causing seizures, helping doctors plan SEEG surgery. It's for people with hard-to-control epilepsy who are already scheduled for SEEG.
BrusselsAges 3 years+ - NCT06432907Recruiting
Brain signal study during movement in epilepsy patients
This study records brain signals from electrodes already placed in your brain for medical reasons. It looks at how your brain controls movement, which could help develop future devices for people with paralysis.
MoscowAges 18–70 - NCT06309251Recruiting
Ketogenic diet for children with epilepsy or other conditions
This trial studies how well a ketogenic diet works for children with hard-to-treat epilepsy or certain other diseases. It aims to see if the diet improves quality of life.
Milan, MIAges Up to 18 years - NCT05534672RecruitingPhase 3
Rapamycin for drug-resistant seizures in tuberous sclerosis
This trial tests whether rapamycin (compared with a placebo) can reduce seizures caused by tuberous sclerosis complex (TSC) that have not been controlled by usual medicines. If you qualify, you may be helping doctors find a safer and more effective option for seizure control.
LodzAges 3 months–50 years - NCT05459090Recruiting
Study of how brain “brakes” work in drug-resistant temporal epilepsy
This study looks at how the brain’s natural “braking” system works in people with drug-resistant temporal lobe epilepsy. It may help researchers better understand the condition in order to improve future treatments.
Pozzilli, IserniaAges Any age - NCT05393518Recruiting
Study linking brain signals to anxiety in people with epilepsy
This study looks at how brain electrical signals relate to anxiety symptoms in people with drug-resistant epilepsy. It compares people who do (or do not) meet criteria for generalized anxiety disorder, to better understand anxiety in this setting.
BordeauxAges 18–65 - NCT07605858Recruiting
Epilepsy, Sleep, and Brain Activity Study
This study examines how seizures affect sleep quality and dreams in people with hard-to-treat focal epilepsy. Researchers will use specialized brain electrodes to understand these connections during sleep, which may help improve treatment in the future.
Durham, North CarolinaAges 18–55 - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Birmingham, AlabamaAges 18–75
Hear when a new Drug Resistant Epilepsy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for drug resistant epilepsy?
- Yes. Clin2 currently lists 58 recruiting drug resistant epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a drug resistant epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a drug resistant epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.