Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,733 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07769281Recruiting
Recovering arm and hand movement after stroke
This study tests a new system called NeuroTechR3 that may help people who have had a stroke regain movement in their arm and hand. It involves training exercises that you can do at home with a computer.
Jacksonville, FloridaAges 18 years+ - NCT06569524RecruitingPhase 2
A new drug for NASH with liver scarring
This study tests a new injected drug (TQA2225/AP025) that may help reduce liver fat and inflammation in people with NASH (a type of fatty liver disease with scarring). It’s for adults who have had a recent liver biopsy and MRI confirming NASH and moderate liver fat.
Lu'an, AnhuiAges 18–75 - NCT06570421Recruiting
Nerve stimulation for Parkinson's and essential tremor
This study tests a non-invasive nerve stimulation device for reducing tremors in people with Parkinson's disease or essential tremor. It follows up participants from a previous trial to see if benefits last up to 24 months.
OstravaAges 18 years+ - NCT06573593Recruiting
JAK inhibitors for children with alopecia areata
This study looks at how well JAK inhibitor pills work for children with alopecia areata (a condition that causes hair loss). If you have tried one of these medicines for at least 3 months, your experience could help doctors learn more about the best treatments.
Hangzhou, ZhejiangAges 2–80 - NCT07759128RecruitingPhase 3
Test of a new anxiety medication for adults with generalized anxiety disorder
This study tests a new medicine (SEP-363856) for adults with generalized anxiety disorder to see if it reduces anxiety symptoms and is safe. It may help if other treatments haven't worked well.
Tucson, ArizonaAges 18 years+ - NCT07758920RecruitingPhase 2
New tablet for long-term shingles pain
This trial tests a new tablet called HL-1186 for treating post-herpetic neuralgia (long-lasting pain after shingles). It compares the new drug to pregabalin, a standard treatment, to see if it's safer and more effective.
BeijingAges 18 years+ - NCT04623099RecruitingPhase 4
Personalized escitalopram dosing for anxious teens
This study tests whether a genetics-guided approach to choosing and adjusting escitalopram (an anxiety medicine) can improve safety and effectiveness for anxious teens. It also checks that participants have certain anxiety severity scores and can safely take the study medication.
Cincinnati, OhioAges 12–17 - NCT07763743Recruiting
Comparing two kidney stone removal methods
This study compares two minimally invasive procedures to remove small-to-medium kidney stones (1 to 2.5 cm). The goal is to see which method is safer and more effective, possibly leading to quicker recovery and fewer side effects.
Cairo, AbbasiaAges 1–14 - NCT06581562RecruitingPhase 1
Testing rituximab plus AB-101 for autoimmune diseases
This trial tests a new treatment (AB-101) combined with rituximab for people with certain autoimmune diseases like rheumatoid arthritis, pemphigus vulgaris, vasculitis, or lupus. It is for those who have not had success with standard therapies.
Plantation, FloridaAges 18 years+ - NCT06141226RecruitingPhase 2
New drug combo for immunotherapy-resistant lung cancer
This trial tests a combination of an immunotherapy drug (TQB2450), a targeted therapy (anlotinib), and chemotherapy for people with advanced non-small cell lung cancer whose cancer stopped responding to prior immunotherapy. It aims to find a new option when the first treatment didn't work anymore.
Huizhou, GuangdongAges 18–75 - NCT06585345RecruitingPhase 1/Phase 2
CD7 CAR-T for relapsed or refractory acute leukemia
This trial tests a new immune therapy called CD7 CAR-T cells for people with acute leukemia that has come back or hasn't gotten better with standard treatments. It aims to see if this treatment is safe and can help control the leukemia.
Chengdu, SichuanAges 14–65 - NCT05831033RecruitingEarly Phase 1
Your own immune T-cells to treat advanced solid tumors
This early-phase study tests a treatment made from your own tumor-fighting immune cells (TIL cells) for advanced solid cancers that have worsened or no longer respond to standard therapy. The main goal is to learn whether it is safe and whether it can shrink tumors for people who have limited options.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06279741RecruitingPhase 1/Phase 2
Cell therapy to prevent lung disease in very premature babies
This study tests whether a special cell therapy (MSC-EVs) given to extremely premature babies can help prevent a serious lung disease called bronchopulmonary dysplasia (BPD). The treatment is given while the baby is still on a breathing machine.
BrusselsAges Up to 1 week - NCT07750951RecruitingPhase 2
Combination therapy before surgery for advanced rectal cancer
This trial tests a combination of two immunotherapy drugs and chemotherapy given before surgery for a type of rectal cancer that has a specific genetic marker (MSI-H/dMMR). The goal is to shrink the tumor and improve the chances of successful surgery.
Xi'an, ShaanxiAges 18 years+ - NCT07754955Recruiting
Two tools for removing large colon polyps compared
This trial compares two special tools used to remove large, flat colon polyps during a colonoscopy. The goal is to see which tool is safer and more effective at removing the entire polyp in one piece, which may help avoid surgery.
Bangkok Noi, BangkokAges 18 years+ - NCT07750249Enrolling by invitationEarly Phase 1
Short-chain fatty acids for IgA nephropathy
This trial tests whether a daily supplement of short-chain fatty acids (SCFAs) can slow down kidney damage in people with IgA nephropathy. SCFAs are substances made by gut bacteria that may help reduce inflammation and protect the kidneys.
MartinAges 18 years+ - NCT07752407RecruitingPhase 3
Heartburn relief study for people with non-erosive GERD
This study tests a new medicine called vonoprazan to see if it can reduce episodes of heartburn in people who have GERD but no damage to their esophagus. It compares the medicine to a placebo (a pill with no active ingredient) over 24 weeks.
Mentor, OhioAges 18 years+ - NCT07754175Recruiting
Stem cell knee treatment for osteoarthritis patients
This study tests a stem cell injection for knee osteoarthritis in patients who previously received a placebo. It aims to see if the treatment is safe and effective over a longer period.
SeoulAges 19 years+ - NCT07755410RecruitingPhase 2
Investigational ADHD treatment for adults
This study tests an investigational medication for adults with attention deficit hyperactivity disorder (ADHD). It aims to see if this new drug helps reduce ADHD symptoms compared to a placebo.
Little Rock, ArkansasAges 18–65 - NCT07752979RecruitingPhase 2
New drug for weight loss in adults with obesity or overweight
This study tests an investigational drug called ABBV-295 to see if it helps adults with obesity or overweight who have weight-related health conditions lose weight. It may offer a new treatment option for managing weight and improving overall health.
Pelham, AlabamaAges 18–75 - NCT06479343Recruiting
Liquid embolic for brain vessel malformations
This trial tests a new liquid material (called a liquid embolic system) that is injected into the abnormal blood vessels in the brain to block them off. It is for people who have a cerebrovascular malformation and can be treated with a catheter from inside the blood vessel.
Guangzhou, GuangdongAges 18–80 - NCT06586242RecruitingPhase 2
Penpulimab, anlotinib, and chemo before surgery for esophageal cancer
This trial tests a combination of three drugs (penpulimab, anlotinib, and chemotherapy) given before surgery to shrink esophageal cancer. It is for people with locally advanced cancer who have not had treatment before.
Xi'an, Shaan'xiAges 18–75 - NCT06577896Recruiting
Onyx stent safety and effectiveness in older adults
This study looks at how well a specific brand of heart stent (Onyx) works in people 75 and older who have narrowed heart arteries. If you've already received an Onyx stent, the study will check its safety and effectiveness over time.
Yangsan, Gyeongsangnam-doAges 75–100 - NCT06590259RecruitingPhase 2
Ablation plus drug therapy for colorectal cancer liver metastases
This trial tests a combination treatment that uses heat or cold (ablation) to destroy liver tumors along with medicines that boost your immune system to fight cancer. It is for people whose colorectal cancer has spread to the liver and who could not have surgery, or whose first treatment stopped working.
ShanghaiAges 18–75
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,733 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.