Clinical trials
Encephalopathy clinical trials
Below are recruiting encephalopathy clinical trials, each written for real people, not researchers. We’re tracking 114 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05673915Recruiting
Brain stimulation study for hard-to-control epilepsy
This trial tests whether noninvasive brain stimulation (using gentle electrical current through the scalp) can reduce seizures in people with epilepsy that has not responded to at least two anti-seizure medicines. If you qualify, you’d also be asked to keep track of seizures in a diary during the study.
Rochester, MinnesotaAges 6 years+ - NCT05836610RecruitingPhase 4
Testing hydrocortisone dosing during newborn cooling
This Phase 4 trial studies the best way to give hydrocortisone (a steroid medicine) to newborns who are being cooled for a specific kind of birth-related lack of oxygen. It’s for babies who have low blood pressure during cooling, aiming to improve their stability while they receive standard treatment.
Budapest, Pest CountyAges Up to 3 days - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT06062628RecruitingEarly Phase 1
Ketamine for severe traumatic brain injury
This study tests whether a low dose of ketamine can help people with severe traumatic brain injury by reducing brain pressure and improving oxygen levels. If you have a brain monitor in place and meet safety criteria, you may be able to join.
Dallas, TexasAges 18 years+ - NCT06172491Recruiting
Automated tool to measure ICU delirium severity
This study tests a computerized tool that automatically measures how severe delirium (sudden confusion) is for ICU patients. Researchers want to see if it can help monitor and manage delirium better without adding extra work for nurses.
Rochester, MinnesotaAges 50 years+ - NCT06195345Recruiting
Brain oxygen study for children having an MRI
This study looks at oxygen levels in the brains of children and young adults (birth to 18 years) during a standard MRI. The goal is to learn more about how the brain works, and it only adds a few minutes to your child's regular MRI scan.
Los Angeles, CaliforniaAges 1 minute–18 years - NCT06278428Recruiting
Epilepsy in Infants: Genes and Disease Course
This study looks at children with severe epilepsy that starts before age 2. It aims to understand how different gene changes affect the disease and how it progresses over time.
Ho Chi Minh CityAges Up to 1.9 years - NCT06368648Recruiting
Study of a new forehead sensor for brain pressure monitoring
This study tests a new sensor that measures brain pressure from outside the head. It is for people who are already in the hospital getting their brain pressure and blood pressure monitored continuously.
Sacramento, CaliforniaAges 18 years+ - NCT06394453Recruiting
Feeding during cooling for brain injury in newborns
This study looks at whether it is safe to give small amounts of milk to babies who are being cooled for brain injury after a difficult birth. It may help doctors decide if feeding during cooling can improve outcomes.
CracowAges Up to 6 hours - NCT06555965Recruiting
STXBP1 and SYNGAP1 natural history study
This study follows people with STXBP1 or SYNGAP1 gene changes over time to learn more about how these conditions affect the body and mind. It does not test a treatment but helps researchers understand the natural course of the disorder.
Palo Alto, CaliforniaAges Any age - NCT06563687Recruiting
Continuous glucose monitoring for HIE newborns
This study tests a continuous glucose monitor (CGM) in newborns with hypoxic-ischemic encephalopathy (HIE) — a type of brain injury from lack of oxygen around birth. The CGM tracks sugar levels to help doctors manage care better.
AvellinoAges Up to 6 hours - NCT06619106Recruiting
Screening tool for minimal hepatic encephalopathy
This study tests a new cognitive tool to quickly and reliably detect minimal hepatic encephalopathy, a subtle brain change that can occur in people with liver disease. If you have a liver condition like fibrosis or cirrhosis and are already scheduled for a full evaluation (neuropsychological tests, MRI, EEG, and blood ammonia), this tool could help simplify future screening.
ParisAges 18–70 - NCT06625112Recruiting
STXBP1 disorder clinical trial readiness study
This study is for people with a confirmed STXBP1 genetic change to help prepare for future clinical trials. It collects information about the condition to better understand it.
AntwerpAges Any age - NCT06643598Recruiting
Virtual and lived-experience support for newborns with brain challenges
This study tests whether a program that combines virtual support and a peer who has been through it can help parents of newborns with certain brain conditions. It is designed for families living in rural areas and aims to improve children's recovery.
Madison, WisconsinAges Up to 5 years - NCT06700811RecruitingPhase 1
Ketogenic diet to prevent infant seizures in genetic epilepsy
This trial tests whether starting a special high-fat diet (ketogenic diet) early can prevent epileptic spasms in babies with genetic epilepsy. It uses a specific formula called KetoVie and is for infants under 9 months old.
Boston, MassachusettsAges birth–9 months - NCT06808074RecruitingPhase 4
Inhaled amikacin to prevent pneumonia in cirrhosis patients on ventilators
This trial tests whether inhaling an antibiotic called amikacin can prevent ventilator-associated pneumonia in patients with severe liver disease (cirrhosis) who are on a breathing machine. If you or your loved one is in the ICU with liver issues and needs a ventilator, this study may help reduce the risk of a serious lung infection.
Hyderabad, TelanganaAges 18 years+ - NCT06857539Recruiting
Assessing thinking and movement in high-risk infants
This study looks at how high-risk infants (especially those born early or with brain concerns) develop their thinking and movement skills over time, comparing them to healthy babies. The goal is to better understand and support their development.
CorkAges birth–4 months - NCT06891716RecruitingEarly Phase 1
PET imaging study for TDP-43 protein disorders
This study uses a special PET scan to detect TDP-43 protein buildup in the brain, which is linked to conditions like frontotemporal dementia and ALS. Healthy volunteers and people with TDP-43 disorders are invited to take part.
AmsterdamAges 40–70 - NCT06958341Recruiting
Brain and nerve disease registry with optional fluid collection
This study collects extra fluid from a spinal tap to learn more about brain and nerve diseases. It may help find better treatments in the future.
Berlin, State of BerlinAges Any age - NCT07190560Recruiting
Study of a treatment for newborns exposed to chikungunya
This trial tests a new treatment (PC-CHIK-V) for newborns whose mothers had chikungunya around the time of birth. The goal is to see if the treatment can prevent or reduce the infection in babies. Babies who are not treated will also be followed for comparison.
Saint-PierreAges birth–2 days - NCT07275021Recruiting
Brain Injury & Vision Screening in Newborns
This study looks for early signs of vision problems in babies who had brain injuries around the time of birth. It aims to help doctors better identify and predict these issues.
Boston, MassachusettsAges 7 months–10 months - NCT07302503Recruiting
MRI study of brain changes in footballers
This study uses a special type of MRI scan to look for tiny changes in the brain's wiring that can happen after head impacts. It compares professional footballers to people who haven't played sports with head impacts, to see if these changes show up on the scan.
StrasbourgAges 32–60 - NCT07363603RecruitingPhase 1/Phase 2
Tianasen for GNAO1-related epilepsy and movement disorders
This trial tests a new drug called Tianasen for children with a specific GNAO1 gene change who have seizures and movement problems that haven't improved with standard treatments. The drug is given via a lumbar puncture (spinal tap) and aims to reduce symptoms.
MoscowAges 1–14 - NCT01858285Recruiting
Genetics study for children with epilepsy
This study looks for genetic (inherited DNA) causes of epilepsy in children. It may help your family better understand what could be driving seizures, even if the cause isn’t known yet.
Boston, MassachusettsAges Any age
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Common questions
- Are there clinical trials for encephalopathy?
- Yes. Clin2 currently lists 114 recruiting encephalopathy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a encephalopathy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a encephalopathy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.